Navigation Links
Stress may make you itch
Date:10/26/2008

Berlin, Germany Current research suggests that stress may activate immune cells in your skin, resulting in inflammatory skin disease. The related report by Joachim et al., "Stress-induced Neurogenic Inflammation in Murine Skin Skews Dendritic Cells towards Maturation and Migration: Key role of ICAM-1/LFA-1 interactions," appears in the November issue of The American Journal of Pathology.

Skin provides the first level of defense to infection, serving not only as a physical barrier, but also as a site for white blood cells to attack invading bacteria and viruses. The immune cells in skin can over-react, however, resulting in inflammatory skin diseases such as atopic dermatitis and psoriasis.

Stress can trigger an outbreak in patients suffering from inflammatory skin conditions. This cross talk between stress perception, which involves the brain, and the skin is mediated the through the "brain-skin connection". Yet, little is know about the means by which stress aggravates skin diseases.

Researchers lead by Dr. Petra Arck of Charit, University of Medicine Berlin and McMaster University in Canada, hypothesized that stress could exacerbate skin disease by increasing the number of immune cells in the skin. To test this hypothesis, they exposed mice to sound stress. Dr. Arck's group found that this stress challenge resulted in higher numbers of mature white blood cells in the skin. Furthermore, blocking the function of two proteins that attract immune cells to the skin, LFA-1 and ICAM-1, prevented the stress-induced increase in white blood cells in the skin.

Taken together, these data suggest that stress activates immune cells, which in turn are central in initiating and perpetuating skin diseases. Fostered by the present observation, the goal of future studies in Dr. Arck's group is to prevent stress-triggered outbreaks of skin diseases by recognizing individuals at risk and identifying immune cells suitable to be targeted in therapeutic interventions.


'/>"/>

Contact: Angela Colmone
acolmone@asip.org
301-634-7953
American Journal of Pathology
Source:Eurekalert

Related biology news :

1. Mice stressed in simulated weightlessness show organ atrophy
2. Heat stress influences low conception of dairy herds
3. Boston College profs study oxidative stress subcellular to discover its role in diseases
4. Researchers find evidence linking stress caused by the Sept. 11 disaster with low birth weights
5. Carnegie Mellon, Pitt Team to study psychosocial stress
6. Social stress + darkness = increased anxiety
7. Relationship between environmental stress and cancer elucidated
8. Cell response to stress signals predicts tumors in women with common pre-breast cancer
9. Asthma link to post-traumatic stress disorder, says Mailman School of Public Health study
10. Buyer beware: Stressed plants wont survive shipping
11. Moderate prenatal exposure to alcohol and stress in monkeys can cause touch sensitivity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/15/2016)... Research and Markets has announced the addition ... report to their offering. ... The global ... from USD 6.21 Billion in 2016, growing at a CAGR of ... bioinformatics market is driven by the growing demand for nucleic acid ...
(Date:6/27/2016)... 27, 2016 Research and Markets has announced ... report to their offering. ... to grow at a CAGR of 12.28% during the ... on an in-depth market analysis with inputs from industry experts. The ... coming years. The report also includes a discussion of the key ...
(Date:6/22/2016)... , June 22, 2016 On Monday, ... call to industry to share solutions for the Biometric ... U.S. Customs and Border Protection (CBP), explains that CBP ... are departing the United States , ... and to defeat imposters. Logo - ...
Breaking Biology News(10 mins):
(Date:12/8/2016)... , Dec. 8, 2016  Soligenix, Inc. (OTCQB: ... company focused on developing and commercializing products to ... medical need, announced today the long-term follow-up data ... (dusquetide), a first-in-class Innate Defense Regulator (IDR), in ... and neck cancer patients undergoing chemoradiation therapy (CRT).  ...
(Date:12/8/2016)... , Dec. 8, 2016  Partnering to fuel ... Franklin Technology Partners of Southeastern Pennsylvania ... the parent company of Independence Blue Cross; and Safeguard ... their intentions for a $6 million funding initiative over ... startups. Responding to a burgeoning economic vitality ...
(Date:12/7/2016)... -- Neogen Corporation (NASDAQ: NEOG ) announced ... as its chief science officer — a new position ... Neogen effective Jan. 1. Kephart has served ... of Thermo Fisher Scientific, as well as animal health ... industry experience also includes the management of a team ...
(Date:12/7/2016)... The report "Acrylic Processing Aid Market by Polymer Type (PVC), Fabrication Process (Extrusion, ... Forecast to 2026", published by MarketsandMarkets, the global market size was USD 645.4 ... registering an of CAGR of 6.2% between 2016 and 2026. ... ... Logo , ...
Breaking Biology Technology: