Navigation Links
Strengthening the tumor-fighting ability of T cells
Date:3/24/2008

When faced with cancer, the immune system dispatches cells, called T cells, to kill the tumor. But these killer cells often fail to completely eliminate the tumor because theyre deactivated by a distinct population of T cells known as regulatory T cells. Past attempts to get rid of these regulatory T cells have largely failed, in part because they share many features with the killer T cells, making it difficult to eliminate one population without also eliminating the other.

In the new study, the researchers focused on a cell-surface protein called OX40 that had previously been shown (in culture dishes) to turn off the regulatory T cells, but turn on the killer T cells. When this protein was activated in mice, the new study shows, the animals eliminated existing tumors and were protected against developing new ones.

The potential drawback of this approach is that selective inhibition of regulatory T cells could provoke naturally self-reactive T cells to attack the bodys own tissues (autoimmunity). The mice in the study, however, showed no signs of autoimmune disease, suggesting that OX40 may be a promising target for anti-cancer therapy.


'/>"/>

Contact: Hema Bashyam
hbashyam@rockefeller.edu
212-327-7053
Journal of Experimental Medicine
Source:Eurekalert

Page: 1

Related biology news :

1. Opportunity for students displaced by Katrina to assess climate vulnerability of Southeast US
2. Global Warming and the Habitability of Planet Earth, Sept. 26
3. Was ability to run early mans Achilles heel?
4. Spaceflight shown to alter ability of bacteria to cause disease
5. Great Plains historical stability vulnerable to future changes
6. UCI researchers restore memory process in most common form of mental disability
7. Cigarette smoking may accelerate disability in those with MS
8. Scientists ramp up ability of poplar plants to disarm toxic pollutants
9. Alaska graduate program in sustainability receives $3.2 million award
10. Food and environmental sustainability focus of ASA-CSSA-SSSA Annual Meetings
11. Predators and parasites may increase evolutionary stability
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2014)... support of peer groups and clinicians is critical ... to recent University of Georgia research. , A ... County area determined that role models for successful ... of infants. , "Mothers who received that support ... said study co-author Alex Anderson, an associate professor ...
(Date:8/28/2014)... MD FASEB MARC (Maximizing Access to Research ... for the American College of Sports Medicine,s Conference ... 2014 in Miami, Florida. These awards are ... doctorates and scientists from underrepresented groups into the ... encourage the participation of young scientists at the ...
(Date:8/28/2014)... million kilometres of new roads will be built worldwide ... Earth,s last wildernesses, where they bring an influx of ... an ambitious study has created a ,global roadmap, for ... balance the competing demands of development and environmental protection. ... that estimates that natural importance of ecosystems and a ...
Breaking Biology News(10 mins):Breastfeeding study shows need for effective peer counseling programs 2Study shows where on the planet new roads should and should not go 2Study shows where on the planet new roads should and should not go 3
... the University of California, San Diego, offer a new explanation ... mammals found along the Malay Peninsula in southeast Asia ... of any geographical barrier. An ancient seaway between the ... have split the peninsula in two, allowing separated populations of ...
... is hard for the children of a parent suffering from ... the ill parent and for other family members. It is ... this and have support functions in place for the whole ... This is the conclusion of a thesis from the Sahlgrenska ...
... release is available in Spanish . , ... research conducted throughout the world,s largest tropical forest. The 30-year ... solid evidence that drought causes massive carbon loss in tropical ... the Amazon forest has been helping to slow down climate ...
Cached Biology News:New explanation for a puzzling biological divide along the Malay Peninsula 2Children seriously affected when a parent suffers from depression 2Amazon carbon sink threatened by drought 2
(Date:8/28/2014)... A new research platform uses a laser ... structures undergoing stress and heating, an approach ... for microelectronics and batteries., This new technique, ... how heating and the surface stress of ... have discussed the merits of surface-stress influence ...
(Date:8/28/2014)... , Aug. 28, 2014 /PRNewswire/ ... new market research report is ... Whole Exome Sequencing Market ... Preparation, Target Enrichment), by Services ... Synthesis), by Application (Cancer, Monogenic ...
(Date:8/28/2014)... -- Next month, executives from clinical trial marketing firm BBK Worldwide ... Patient-Centered Clinical Trials 2014 , to be held at ... September 4-5. Patient recruitment experts Bonnie A. Brescia , ... share insights on the benefits of employing an effective patient ... media to mobile apps – can be used to drive ...
(Date:8/28/2014)... WA (PRWEB) August 28, 2014 Sterlitech ... Filtration’s polymeric membranes to its stable of products ... available molecular weight cut-offs and include membrane filters with ... steady increase in customer demand for our membrane process ... greater variety of flat sheet membranes,” explains Sterlitech President ...
Breaking Biology Technology:New analytical technology reveals 'nanomechanical' surface traits 2New analytical technology reveals 'nanomechanical' surface traits 3Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 2Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 3Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 4Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 5Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 6Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 7Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 8Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 9Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 10Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 11Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 12Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 13BBK Worldwide Leads Sessions at Key September Events 2Sterlitech Corporation Enhances Its Selection of Flat Sheet Membrane Filters 2
... Calif., Jan. 21 , ... -- Organizations spanning the life sciences industry ... and,pharmaceutical manufacturers -- are increasingly turning to ... trials more efficiently and effectively. , , ...
... eTrinsic, a division of Simbionix USA,Corporation (Simbionix), a ... training medical salespeople and professionals, today,announced that Glen ... for the,Midwest and Eastern Region. Glen will work ... , Glen brings strong ...
... SAN DIEGO, Jan. 20 (Nasdaq: SQNM ) Analyst and Investor Briefing and ... Prenatal, Diagnostics Analyst ... 2009 from 5:30 p.m. to 8:00 p.m., Where: www.sequenom.com/Corporate/Investor-Relations, ... to the Web at the, ...
Cached Biology Technology:Life Sciences Organizations Choose Oracle to Accelerate and Simplify Clinical Trial Data Collection 2Life Sciences Organizations Choose Oracle to Accelerate and Simplify Clinical Trial Data Collection 3Life Sciences Organizations Choose Oracle to Accelerate and Simplify Clinical Trial Data Collection 4Glen C. Williams Joins eLearning Sales Team for Simbionix, Heading up Chicago Office 2Webcast Alert: Sequenom: Defining the Future of Noninvasive Prenatal Diagnostics 2
IHC Polymer Detection Kit (Rabbit DAB)150 slides...
... (1995) • This book is unique ... and molecular techniques currently used in ... analysis of virus-specific antibodies and clinical ... covering immunoassays, blotting and hybridization procedures, ...
Performance, mycoplasma, virus, and endotoxin tested. Collected from calves 14 days old or less...
Bovine Serum...
Biology Products: