Navigation Links
Stowers study hints that stem cells prepare for maturity much earlier than anticipated
Date:12/27/2012

ted gene by initiating a global search for regions occupied by Ell3 in the genome of mouse embryonic stem cells. His search in collaboration with a bioinformatician in the Shilatifard lab, Alexander S. Garruss, revealed that Ell3 sits on more than 5,000 enhancers, including many that regulate genes governing stem cell maturation into spinal cord, kidney, and blood cells.

"What was interesting was that Ell3 marked enhancers that are active and inactive, as well as enhancers that are known as "poised," says Lin, referring to a transition state from inactive to active. "That indicated that Ell3's major function might be to prime activation of genes that are just about to be expressed during development."

The fact that silent genes can be "primed" for expression was no surprise: researchers knew that the enzymatic machine that copies DNA into the RNA blueprint for proteinsa protein called Pol IIoften pauses at the start of a gene, presumably revving its engine in preparation to jump across the genetic start gate in response to a developmental signal. However, Shilatifard and colleagues showed several years ago that paused Pol II is not a prerequisite for rapid transcriptional induction.

The surprise came when researchers used a molecular trick to deplete mouse ES cells of Ell3 and then did a "genomic" survey. They found that paused Pol II vanished from the start sites of many genes in Ell3-deficient cells. This means that not only does Ell3 preferentially mark stem enhancers, but also that its presence there is necessary to keep an idling Pol II ready for action.

Most of the current study defines how, when the developmental time is right, enhancer-bound Ell3 cooperates with components of a big-boss elongation factor called the Super Elongation Complex to release Pol II from the start gate, allowing the expression of genes required for stem cell differentiation. Critical among those findings is their observation that mouse stem cell
'/>"/>

Contact: Gina Kirchweger
gxk@stowers.org
816-806-1036
Stowers Institute for Medical Research
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Birdsong study pecks theory that music is uniquely human
2. Study turns parasite invasion theory on its head
3. Gout study offers genetic insight into disease of kings
4. Native orchid protection and conservation subject of new AgriLife Research study
5. Cell Transplantation study investigates fate and function of cells transplanted to the CNS
6. Study reports iron oxide nanoparticles effective for labeling human endothelial cells
7. Study looks at gray seal impact on beach water quality
8. Study reveals that animals contribute to seagrass dispersal
9. UC Irvine study of leaping toads reveals muscle-protecting mechanism
10. NTU study finds ways to prevent muscle loss, obesity and diabetes
11. Hass Avocado Board study published in Food & Function journal
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Stowers study hints that stem cells prepare for maturity much earlier than anticipated
(Date:1/22/2015)... Technology Showcase, Hall E -   EyeLock Inc. , a ... will showcase its EyeLock ID technology integrated in a 3D ... Oak Ridge National Laboratory (ORNL) at the 2015 ... authentication technology is being used to validate the driver and ...
(Date:1/22/2015)... NXT-ID, Inc. (NASDAQ: NXTD and NXTDW) a biometric authentication ... success of the Wocket™ smart wallet at CES 2015 in ... as one of the "11 Hot Products at CES" in a review ... So Far" by Newseveryday.com and "The top 10 gadgets from CES 2015" ...
(Date:1/22/2015)... 2015 , Europe,s ... The European Patent Office to present a video retrospective of the ... be featured: Christofer Toumazou and Sophie Wilson   ... winners of the Award   Starting on 22 January ...
Breaking Biology News(10 mins):EyeLock Debuts First Iris Authentication Technology Embedded in 3D Printed Automobile 2EyeLock Debuts First Iris Authentication Technology Embedded in 3D Printed Automobile 3CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 2CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 3Ten Years of the European Inventor Award: A Retrospective Look at the Inventors and Ideas That Have Changed Our Lives 2Ten Years of the European Inventor Award: A Retrospective Look at the Inventors and Ideas That Have Changed Our Lives 3
... location of every atom in a 450-million-yeard-old resurrected protein ... molecules modern version, according to researchers from the University ... of Oregon. Until now, scientists trying to unravel ... for life have worked backwards, making educated guesses based ...
... Caledonian crowswhich are known to make complex food-getting tools ... another to get a snack. The researchers report their ... of Cell Press. The birds, tool-use skills rival ... Moreover, it appears that the birds may have solved ...
... Parents should think twice before offering a low-fat menu to ... than adults for each calorie spent, according to research in ... can be included as part of a childs healthy and ... Kostyak from The Pennsylvania State University used calorimetry to measure ...
Cached Biology News:Structure of 450 million year old protein reveals evolution's steps 2New caledonian crows find 2 tools better than 1 2Fat still on the children's menu 2
(Date:1/22/2015)... WI (PRWEB) January 22, 2015 Dr. Greg ... the 12th annual Scripps Natural Supplements Pre-Conference seminar on probiotics ... Conference is an annual continuing education conference for health care ... and included the topic of probiotics in health. Dr. Leyer ...
(Date:1/22/2015)... 2015   Cypher Genomics, Inc., the leading ... SQNM ), the leading molecular diagnostics company, ... noninvasive prenatal tests (NIPT). Through this agreement, Sequenom ... to advance analysis of clinically-relevant fetal sub-chromosomal variants ...
(Date:12/24/2014)... , Dec. 24, 2014  United Therapeutics Corporation (NASDAQ: ... MDT ) has submitted a pre-market approval ... for the use of Medtronic,s SynchroMed ® II ... for use with United Therapeutics, Remodulin ® (treprostinil) ...
(Date:12/24/2014)... GMO corn cases filed across the United States, and ... being consolidated in a Kansas federal court for pretrial proceedings. ... Corn Litigation, MDL No. 2591 in the U.S. District Court ... GMO corn multidistrict litigation (MDL) has been handed over to ...
Breaking Biology Technology:Cypher Genomics and Sequenom Announce Development Agreement 2Cypher Genomics and Sequenom Announce Development Agreement 3Cypher Genomics and Sequenom Announce Development Agreement 4United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 2United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 3United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 4Carey Danis & Lowe Reports on Syngenta GMO Corn Transfer Order 2
... ... (or RNA). To help illustrate the basics of DNA origami, Harvard’s Wyss Institute has created ... abstract representation of a DNA molecule and then allowing it to self assemble. , ... Boston, Mass. (PRWEB) January 28, 2010 ...
... N.J. , Jan. 27 Covance Inc. (NYSE: ... 31, 2009 of $0.64 per diluted share.  For the ... inclusive of $0.10 per share in gains related to sales ... the third quarter.  Excluding the gains on sales and the tax item, ...
... , , WASHINGTON ... source of adult stem cells, which are increasingly used for research ... often painful process. Now, researchers have found evidence that fat tissue, ... valuable and easy-to-obtain regenerative cells called hematopoietic stem and progenitor cells ...
Cached Biology Technology:Wyss Institute Launches "Molecular Origami" Interactive Feature 2Wyss Institute Launches "Molecular Origami" Interactive Feature 3Covance Reports Fourth Quarter Revenue of $485M and EPS of $0.64 Per Share 2Covance Reports Fourth Quarter Revenue of $485M and EPS of $0.64 Per Share 3Covance Reports Fourth Quarter Revenue of $485M and EPS of $0.64 Per Share 4Covance Reports Fourth Quarter Revenue of $485M and EPS of $0.64 Per Share 5Covance Reports Fourth Quarter Revenue of $485M and EPS of $0.64 Per Share 6Covance Reports Fourth Quarter Revenue of $485M and EPS of $0.64 Per Share 7Covance Reports Fourth Quarter Revenue of $485M and EPS of $0.64 Per Share 8Covance Reports Fourth Quarter Revenue of $485M and EPS of $0.64 Per Share 9Covance Reports Fourth Quarter Revenue of $485M and EPS of $0.64 Per Share 10Covance Reports Fourth Quarter Revenue of $485M and EPS of $0.64 Per Share 11Covance Reports Fourth Quarter Revenue of $485M and EPS of $0.64 Per Share 12Covance Reports Fourth Quarter Revenue of $485M and EPS of $0.64 Per Share 13Covance Reports Fourth Quarter Revenue of $485M and EPS of $0.64 Per Share 14Covance Reports Fourth Quarter Revenue of $485M and EPS of $0.64 Per Share 15Covance Reports Fourth Quarter Revenue of $485M and EPS of $0.64 Per Share 16Covance Reports Fourth Quarter Revenue of $485M and EPS of $0.64 Per Share 17Fat Tissue May Be a Source of Valuable Blood Stem Cells, Study Says 2Fat Tissue May Be a Source of Valuable Blood Stem Cells, Study Says 3Fat Tissue May Be a Source of Valuable Blood Stem Cells, Study Says 4
Ultra-sensitive, non-radioactive detection of Protein G. Measure Protein G levels quickly and easily....
IC50: 190 pg/ml · Limit of detection: 60 pg/ml...
Request Info...
Request Info...
Biology Products: