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Stowers Institute's Xie Lab demonstrates dual intrinsic and extrinsic control of stem cell aging
Date:10/10/2007

adhesion can enhance stem cell aging.

Finally, the paper highlights how over-expression of an enzyme that helps eliminate free oxygen species, either in GSCs or in their niche, can prolong the lifespan of stem cells and increase proliferation.

Inefficient replacement of worn-out cells in adult tissues due to the declining function of stem cells over time may be a primary cause of human aging, says Dr. Xie. If we learn how to slow down stem cell aging by manipulating functions of stem cells and/or their niche, we may be able to slow down human aging and the progression of age-related degenerative diseases.


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Contact: Marie Jennings
mfj@stowers-institute.org
816-926-4015
Stowers Institute for Medical Research
Source:Eurekalert

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