Navigation Links
Stowers Institute's Xie Lab demonstrates dual intrinsic and extrinsic control of stem cell aging

The Stowers Institutes Xie Lab has published recent findings that reveal some of the factors underlying the aging of stem cells.

The paper, Stem Cell Aging is Controlled both Intrinsically and Extrinsically in the Drosophila Ovary, was published in the Oct. 11 issue of Cell Stem Cell. Lei Pan, Predoctoral Researcher, and Ting Xie, Ph.D., Associate Investigator, are the papers first and last authors, respectively.

It is widely postulated that a decrease in the number and activity of stem cells contributes to the aging of human tissue. These changes could be fundamental to many symptoms of aging such as wrinkling of skin and decreased organ function.

The control of stem cell aging has, until now, been poorly understood, but the Xie Lab has demonstrated that specific factors are associated with an age-dependent decline in the function of stem cells and their microenvironment, called a niche.

In this study, we used Drosophila (fruit fly) ovarian germline stem cells (GSCs) as a model to demonstrate that age-dependent decline in the functions of stem cells and their niche contributes to overall aging of stem cells, said Mr. Pan. We examined three factors in the control of stem cell aging and found evidence that it is controlled both extrinsically and intrinsically.

First, the team examined a family of proteins called bone morphogenic proteins (BMPs), which plays an important role in the development of many tissues. They found that as BMP signaling activity from the niche decreases with age, the stem cells ability to proliferate is compromised, and the stem cell population declines. Conversely, they established that an increase in BMP signaling can prolong the lifespan of stem cells and promote proliferation.

Second, the team established that time also takes a toll on the adhesion between stem cells and their niche. Strong adhesion can prolong a stem cells lifespan, and weakened adhesion can enhance stem cell aging.

Finally, the paper highlights how over-expression of an enzyme that helps eliminate free oxygen species, either in GSCs or in their niche, can prolong the lifespan of stem cells and increase proliferation.

Inefficient replacement of worn-out cells in adult tissues due to the declining function of stem cells over time may be a primary cause of human aging, says Dr. Xie. If we learn how to slow down stem cell aging by manipulating functions of stem cells and/or their niche, we may be able to slow down human aging and the progression of age-related degenerative diseases.


Contact: Marie Jennings
Stowers Institute for Medical Research

Related biology news :

1. Stowers scientists demonstrate mechanism of vertebral formation
2. BioMed Central welcomes the new National Institutes of Health public access policy
3. Virginia Bioinformatics Institutes launches microbial database
4. Study Demonstrates Gene Expression Microarrays are Comparable and Reproducible
5. MRSA study demonstrates need for frequent hand washing and environmental disinfection in health care settings
6. Sangamo BioSciences demonstrates its ZFP treatment protects cells from HIV infection
7. New research demonstrates bone-marrow derived stem cells can reverse genetic kidney disease
8. Xie Lab demonstrates the role of microRNA pathway
9. Intrinsic eye protein halts angiogenesis
10. Ancient olfaction protein is shared by many bugs, offering new pest control target
11. Gene variations explain drug dose required to control seizures
Post Your Comments:
(Date:12/1/2015)... Calif. , Dec. 1, 2015 Synaptics ... human interface solutions, today announced a new agreement with ... OEMs with real-world test and development environments that combine ... solutions. The partnership reduces the complexity of FIDO certification ... software permits Synaptics and OEMs to verify FIDO enabled ...
(Date:11/30/2015)... BEACH, Fla. , Nov. 30, 2015 /PRNewswire/ ... as a finalist in this year,s Fierce Innovation Awards:  ... of FierceHealthIT , FierceHealthcare ... was recognized as a finalist in the category ... --> ...
(Date:11/26/2015)... Research and Markets ( ) has ... - Technology and Patent Infringement Risk Analysis" report ... --> Fingerprint sensors using capacitive technology represent ... sensor vendor Idex forecasts an increase of 360% of ... and of the fingerprint sensor market between 2014 and ...
Breaking Biology News(10 mins):
(Date:12/1/2015)... -- Twist Bioscience, a company focused on synthetic DNA, today announced ... selected as one of Foreign Policy,s 100 Leading ... of life . Each year, Foreign Policy selects ... have changed lives and are shaping the world. ... to be recognized among these incredible global leaders," said Leproust. ...
(Date:12/1/2015)... 2015 Oxford Finance LLC ("Oxford"), a specialty ... and healthcare services companies, today announced the closing of ... Inc. ("the Company"). Proceeds from the loan are being ... Company,s Rejuvaphyl™ and daily skincare products. ... brand of high potency skincare products that contain the ...
(Date:12/1/2015)... Dec. 01, 2015 ... of the "2016 Europe Cell Surface ... Technologies, Competitive Strategies, Opportunities for Suppliers--France, Germany, ... offering. --> ) has ... Europe Cell Surface Markers: Country Volume and ...
(Date:12/1/2015)... ... December 01, 2015 , ... Park Systems , ... add-on scanning ion conductance microscopy module to Park NX10 that is the only ... Park SICM benefits virtually all materials characterization that require measurements in liquid such ...
Breaking Biology Technology: