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Stowers Institute's Workman Lab discovers novel histone demethylase protein complex
Date:12/5/2008

uman health especially as it relates to Huntington disease. The human enzyme that adds methylation marks on histone H3K36 interacts with the Huntington protein, which causes Huntington's disease. Additionally, the human version of dKDM4A functions as an oncogene, which has the potential to cause a normal cell to become cancerous. Overexpression of such a gene product can lead to esophageal squamous carcinoma and prostate cancer. The Workman Lab's efforts to learn more about the dynamic regulation of H3K36 methylation may lead to the discovery of potential mechanisms to cure or alleviate these diseases.


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Contact: Marie Jennings
mfj@stowers-institute.org
816-926-4015
Stowers Institute for Medical Research
Source:Eurekalert

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