Navigation Links
Stowers Institute's Workman Lab discovers novel histone demethylase protein complex
Date:12/5/2008

The Stowers Institute's Workman Lab has discovered a novel histone demethylase protein complex characterized in work published today in Molecular Cell.

The Histone H3 protein is an important component of chromatin, the packing material wrapping up chromosomal DNA and preventing unwanted transcription of the message encoded in the DNA. Histone H3 can be altered by adding (methylating) or removing (demethylating) methyl groups from the histone protein. When genes are transcribed, parts of chromosomes are opened, making them susceptible to inappropriate use. Cells mark transcribed regions of chromosomes with a "landmark," called H3 lysine 36 methylation (H3K36), to direct appropriate use.

Working in fruit flies, the Workman Lab investigated how cells direct dKDM4A, a novel histone demethylase protein, to specific locations, which is important because dKDM4A is responsible for removal of landmark histone modifications during transcription elongation.

"We discovered that dKDM4A can remove specific forms of H3K36, reversing methylation and helping to regulate transcription elongation," said Chia-Hui Lin, Predoctoral Researcher and lead author on the paper. "Surprisingly, we found that dKDM4a associates with Heterochromatin Protein 1a (HP1a), a classic transcriptional silencing factor. The binding of HP1a stimulates the histone demethylation activity of dKDM4A. In fruit fly larvae without HP1a, we found a significantly increased level of H3K36."

"It is known that HP1a acts as a 'scaffold' component during transcription silencing, but recent findings of HP1a's involvement in actively transcribed regions had confounded the chromatin field," said Jerry Workman, Ph.D., Investigator and senior author on the paper. "This work suggests a possible role for HP1a in transcription activation by facilitating histone demethylation by dKDM4A to remove an important histone mark during elongation."

The discovery applies to human health especially as it relates to Huntington disease. The human enzyme that adds methylation marks on histone H3K36 interacts with the Huntington protein, which causes Huntington's disease. Additionally, the human version of dKDM4A functions as an oncogene, which has the potential to cause a normal cell to become cancerous. Overexpression of such a gene product can lead to esophageal squamous carcinoma and prostate cancer. The Workman Lab's efforts to learn more about the dynamic regulation of H3K36 methylation may lead to the discovery of potential mechanisms to cure or alleviate these diseases.


'/>"/>

Contact: Marie Jennings
mfj@stowers-institute.org
816-926-4015
Stowers Institute for Medical Research
Source:Eurekalert

Related biology news :

1. Stowers Institutes Shilatifard Lab identifies new role for factor critical to transcription
2. Stowers Institute researchers identify gene linked to vertebral defects in patient populations
3. Stowers Proteomics Center devises method for assigning probabilities to human protein interactions
4. Stowers Institutes Hawley Lab identifies factors responsible for restart of meiotic cycle
5. Stowers Institutes Xie Lab demonstrates dual intrinsic and extrinsic control of stem cell aging
6. New study spotlights National Institutes of Health grant outcomes for clinical research
7. National Institutes of Health award Williams professor $217,710 research grant
8. Workman Lab characterizes novel regulator of chromosome function
9. Texas A&M anthropologist discovers long-lost primate in Indonesia
10. International team discovers gene associated with epilepsy
11. UCR graduate student discovers, names bacterium linked to psyllid yellows
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... 2016 Research and Markets has announced the ... report to their offering. The ... to grow at a CAGR of 12.28% during the period ... an in-depth market analysis with inputs from industry experts. The report ... years. The report also includes a discussion of the key vendors ...
(Date:6/21/2016)... VANCOUVER, British Columbia , June 21, 2016 ... been appointed to the new role of principal ... has been named the director of customer development. ... , NuData,s chief technical officer. The moves reflect ... development teams in response to high customer demand ...
(Date:6/9/2016)... 9, 2016  Perkotek an innovation leader in attendance control systems is proud to ... hours, for employers to make sure the right employees are actually signing in, and ... ... ... ...
Breaking Biology News(10 mins):
(Date:12/8/2016)... 2016 Savannah River Remediation LLC group ... NewTechBio,s NT-MAX Lake & Pond Sludge and ... in conjunction with Hexa Armor/ Rhombo cover manufactured ... Pollutant Discharge Elimination System requirements. The ... history of elevated pH levels, above 8.5, especially ...
(Date:12/7/2016)... ... December 07, 2016 , ... A new study ... setting of previously treated, advanced pancreatic cancer, liquid biopsies are not yet an ... and timing of blood sampling may improve the value of a blood-based test.” ...
(Date:12/7/2016)... 2016  Nordion, a standalone business of Sterigenics ... today,s award by the United States Department of ... the Phase II cooperative agreement funding to GA ... University of Missouri Research Reactor Center (MURR ® ... establishment of a new, reliable supply of molybdenum ...
(Date:12/7/2016)... , Dec. 7, 2016  Muse bio, a privately-held ... today announced that Dr. Kevin Ness has ... Board of Directors. Kevin succeeds Muse ... the company,s Chief Science Officer as well as remains ... of the BioDesign Center at the RAS Energy Institute ...
Breaking Biology Technology: