Navigation Links
Stowers Institute's Shilatifard Lab identifies new role for factor critical to transcription
Date:6/17/2008

The Stowers Institute's Shilatifard Lab has identified a new role for the elongation factor ELL in gene transcription by RNA polymerase II (Pol II) the enzyme that synthesizes messenger RNA to carry genetic information from DNA to the protein-synthesizing machinery of the cell.

Precise control of the timing and location of transcript elongation by Pol II is essential for development. In a paper published online in the Early Edition of the Proceedings of the National Academy of Sciences (PNAS), the team found that ELL plays a fundamental role in the regulation of gene expression by causing temporary interruptions of the action of Pol II in the fruit fly (Drosophila melanogaster).

"Biological mechanisms such as the 'pausing' of Pol II at nearby promoters have been found at many regulated genes," explained Ali Shilatifard, Ph.D., Investigator. "In this study, we wanted to determine whether the elongation factor ELL is required for the regulation of the temporary interruptions of Pol II transcription in a living organism."

"ELL is found in translocation with the MLL gene in childhood leukemia," said Edwin Smith, Ph.D., Research Scientist in the Shilatifard Lab. "We know very little about the role of these factors in the pathogenesis of leukemia and, therefore, understanding the molecular basis of ELL function will be instrumental for future studies aimed at developing targeted therapeutics for the treatment of translocation-based leukemia."

The Shilatifard Lab will continue to work with the reagents developed in this study to learn more about the molecular properties of ELL in the fruit fly in the hope of elucidating the role of ELL in human disease.


'/>"/>

Contact: Marie Jennings
816-926-4015
Stowers Institute for Medical Research
Source:Eurekalert

Page: 1

Related biology news :

1. Stowers Institutes Xie Lab demonstrates dual intrinsic and extrinsic control of stem cell aging
2. Stowers Institutes Hawley Lab identifies factors responsible for restart of meiotic cycle
3. Stowers Proteomics Center devises method for assigning probabilities to human protein interactions
4. Stowers Institute researchers identify gene linked to vertebral defects in patient populations
5. Shilatifard Lab sheds light on molecular machinery required for translation of histone crosstalk
6. Study identifies warning signs of pregnancy danger
7. Study identifies genetic risk factor for rheumatoid arthritis, lupus
8. Study by Pittsburgh researchers identifies possible vaccine target for chlamydia
9. Breakthrough research identifies how cells from pigs may cure diabetes
10. Smithsonian identifies invasive crab species in Panama Canal expansion area
11. Smithsonian identifies invasive crab species in Panama Canal expansion area
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/30/2017)... , June 30, 2017 Today, American ... and supplier of face and eye tracking software, ... Product provider program. "Artificial intelligence ... way to monitor a driver,s attentiveness levels while ... being able to detect fatigue and prevent potential ...
(Date:5/16/2017)... , May 16, 2017  Veratad Technologies, LLC ( ... online age and identity verification solutions, announced today they ... Conference 2017, May 15 thru May 17, 2017, in ... and International Trade Center. Identity impacts ... and in today,s quickly evolving digital world, defining identity ...
(Date:4/19/2017)... 2017 The global military biometrics ... marked by the presence of several large global players. ... five major players - 3M Cogent, NEC Corporation, M2SYS ... nearly 61% of the global military biometric market in ... global military biometrics market boast global presence, which has ...
Breaking Biology News(10 mins):
(Date:7/20/2017)... , ... July 20, 2017 , ... ... Fujimoto, Ph.D ., the Elihu Thomson Professor of Electrical Engineering and Computer Science ... Award winner. Presented annually, the award recognizes an individual who has made ...
(Date:7/20/2017)... TX (PRWEB) , ... July 20, 2017 , ... ... focused on health-related quality of life, today announced its full advisory board. The ... also announced the promotion of James Crooks, PhD, former VP of Engineering, to ...
(Date:7/20/2017)... and PLYMOUTH, Minn., July 20, 2017   ... a personalized genetic evaluations company, today announced that ... partnership investigating a genetic mutation implicated in KCNQ2 ... the partnership for a second case involving an ... the KCNQ2 Cure Alliance and Pairnomix entered into ...
(Date:7/18/2017)... , ... July 18, 2017 , ... ... accelerate pharmaceutical and biotherapeutics development, announces the launch of a new NTA biosensor ... chip enables researchers to study the kinetics of polyhistidine-tagged (His-tagged) molecules quickly and ...
Breaking Biology Technology: