Navigation Links
Stowers Institute's Shilatifard Lab identifies new role for factor critical to transcription
Date:6/17/2008

The Stowers Institute's Shilatifard Lab has identified a new role for the elongation factor ELL in gene transcription by RNA polymerase II (Pol II) the enzyme that synthesizes messenger RNA to carry genetic information from DNA to the protein-synthesizing machinery of the cell.

Precise control of the timing and location of transcript elongation by Pol II is essential for development. In a paper published online in the Early Edition of the Proceedings of the National Academy of Sciences (PNAS), the team found that ELL plays a fundamental role in the regulation of gene expression by causing temporary interruptions of the action of Pol II in the fruit fly (Drosophila melanogaster).

"Biological mechanisms such as the 'pausing' of Pol II at nearby promoters have been found at many regulated genes," explained Ali Shilatifard, Ph.D., Investigator. "In this study, we wanted to determine whether the elongation factor ELL is required for the regulation of the temporary interruptions of Pol II transcription in a living organism."

"ELL is found in translocation with the MLL gene in childhood leukemia," said Edwin Smith, Ph.D., Research Scientist in the Shilatifard Lab. "We know very little about the role of these factors in the pathogenesis of leukemia and, therefore, understanding the molecular basis of ELL function will be instrumental for future studies aimed at developing targeted therapeutics for the treatment of translocation-based leukemia."

The Shilatifard Lab will continue to work with the reagents developed in this study to learn more about the molecular properties of ELL in the fruit fly in the hope of elucidating the role of ELL in human disease.


'/>"/>

Contact: Marie Jennings
816-926-4015
Stowers Institute for Medical Research
Source:Eurekalert

Page: 1

Related biology news :

1. Stowers Institutes Xie Lab demonstrates dual intrinsic and extrinsic control of stem cell aging
2. Stowers Institutes Hawley Lab identifies factors responsible for restart of meiotic cycle
3. Stowers Proteomics Center devises method for assigning probabilities to human protein interactions
4. Stowers Institute researchers identify gene linked to vertebral defects in patient populations
5. Shilatifard Lab sheds light on molecular machinery required for translation of histone crosstalk
6. Study identifies warning signs of pregnancy danger
7. Study identifies genetic risk factor for rheumatoid arthritis, lupus
8. Study by Pittsburgh researchers identifies possible vaccine target for chlamydia
9. Breakthrough research identifies how cells from pigs may cure diabetes
10. Smithsonian identifies invasive crab species in Panama Canal expansion area
11. Smithsonian identifies invasive crab species in Panama Canal expansion area
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/4/2017)... BLOOMINGTON, Ill. , Oct. 4, 2017  GCE Solutions, a ... powerful new data and document anonymization solution on October 4, 2017. ... the pharmaceutical field to comply with policy 0070 of the European ... documents and data. ... Innovation by GCE Solutions ...
(Date:6/23/2017)... and ITHACA, N.Y. , ... and Cornell University, a leader in dairy research, today ... bioinformatics designed to help reduce the chances that the ... the onset of this dairy project, Cornell University has ... for Sequencing the Food Supply Chain, a food safety ...
(Date:5/6/2017)... RAM Group , Singaporean based ... in biometric authentication based on a novel  ... to perform biometric authentication. These new sensors are based on ... Ram Group and its partners. This sensor will have ... and security. Ram Group is a next generation ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... BioMarketing, a leading provider of patient support solutions, has announced ... network, which will launch this week. The VMS CNEs will ... to enhance the patient care experience by delivering peer-to-peer education ... professionals to help women who have been diagnosed and are ... ...
(Date:10/10/2017)... ... October 10, 2017 , ... San Diego-based team building ... corporate rebranding initiative announced today. The bold new look is part of a ... company moves into a significant growth period. , It will also expand its service ...
(Date:10/10/2017)... Oct. 10, 2017 SomaGenics announced the receipt ... to develop RealSeq®-SC (Single Cell), expected to be the ... RNAs (including microRNAs) from single cells using NGS methods. ... need to accelerate development of approaches to analyze the ... "New techniques for measuring levels of mRNAs in ...
(Date:10/9/2017)... ... October 09, 2017 , ... At its national board meeting in North ... in Harvard University’s Departments of Physics and Astronomy, has been selected for membership in ... winning team for the 2015 Breakthrough Prize in Fundamental physics for the discovery of ...
Breaking Biology Technology: