Navigation Links
Stowers Institute's Linheng Li Lab expands understanding of bone marrow stem cell niche
Date:12/5/2008

The Stowers Institute's Linheng Li Lab has identified the precise location of the bone marrow stem cell niche. The findings were published today in the Advance Online Publication of Nature.

The Linheng Li Lab collaborated with several of the Institute's support facilities to develop a new technology ex vivo Imaging of Stem Cells, or EVISC to monitor the dynamic behavior of stem cells. This technology enabled the team to track the homing of hematopoietic stem cells after being transplanted in mice. The findings build on the Linheng Li Lab's 2003 discovery of the hematopoietic stem cell (HSC) niche (Zhang, et al. in the October 23, 2003 issue of Nature).

"Using the EVISC technology, we were able to confirm our 2003 findings that HSCs tend to home to the inner bone surface," said Yucai Xie, Predoctoral Researcher and co-equal first author on the paper. "Additionally, we were able to resolve a debate in the field about whether the bone-forming niche or the blood-vessel-forming niche actually nurtures HSCs. Surprisingly, we revealed that the inner bone surface forms a special zone that includes both osteoblastic and endothelial components. This HSC zone maintains HSCs in their resting state and promotes HSC expansion in response to bone marrow stressors, such as irradiation."

Tong Yin, Ph.D., Postdoctoral Research Fellow, is also a co-equal first author on the paper.

A better understanding of the HSC niche may lead to more effective bone marrow transplants since a more precise understanding of the microenvironment that nurtures these therapeutically valuable cells will give physicians greater control over the entire process.

"The new technique developed in this study may have a variety of applications including monitoring other types of cells in low population numbers in vivo," said Winfried Wiegraebe, Ph.D., Director of Advanced Instrumentation and Physics, who provided the key assistance in the two-photon microscopic experiments.

"EVISC technology will allow us to study HSC lineage commitment in vivo," said Linheng Li, Ph.D., Investigator and senior author on the paper. "Furthermore, we will be able to use this technology to study leukemia (and other cancer) stem cells to better understand whether they use the same or different niches that normal stem cells use, and even to evaluate drug resistance and treatment responses. This is an exciting new avenue for our work."


'/>"/>

Contact: Marie Jennings
mfj@stowers-institute.org
816-926-4015
Stowers Institute for Medical Research
Source:Eurekalert

Related biology news :

1. Stowers Institutes Xie Lab demonstrates dual intrinsic and extrinsic control of stem cell aging
2. Stowers Institutes Hawley Lab identifies factors responsible for restart of meiotic cycle
3. Stowers Proteomics Center devises method for assigning probabilities to human protein interactions
4. Stowers Institute researchers identify gene linked to vertebral defects in patient populations
5. Stowers Institutes Shilatifard Lab identifies new role for factor critical to transcription
6. Stowers Institutes Workman Lab discovers novel histone demethylase protein complex
7. National Institutes of Health award Williams professor $217,710 research grant
8. New study spotlights National Institutes of Health grant outcomes for clinical research
9. Ossur -- leading orthopedic pioneer - expands network to Asia
10. Monsanto expands sponsorship for Peking-Yale Joint Agrobiotechnology Center
11. DHS Expands Biometrics-at-Sea Program to the Florida Straits
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/11/2017)... 2017 Research and Markets has announced the ... to their offering. ... eye tracking market to grow at a CAGR of 30.37% during ... Market 2017-2021, has been prepared based on an in-depth market analysis ... and its growth prospects over the coming years. The report also ...
(Date:4/5/2017)... SEATTLE , April 5, 2017  The Allen ... the Allen Cell Explorer: a one-of-a-kind portal and dynamic ... large-scale 3D imaging data, the first application of deep ... edited human stem cell lines and a growing suite ... the platform for these and future publicly available resources ...
(Date:4/3/2017)... 2017  Data captured by IsoCode, IsoPlexis ... a statistically significant association between the potency ... and objective response of cancer patients post-treatment. ... whether cancer patients will respond to CAR-T ... as to improve both pre-infusion potency testing and ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... The Blavatnik ... Winners and six Finalists of the 2017 Blavatnik Regional Awards for Young Scientists. ... Foundation and administered by the New York Academy of Sciences to honor the ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... a United States multicenter, prospective clinical study that demonstrates the accuracy of ... capable of identifying clinically significant acute bacterial and viral respiratory tract infections ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... the pharmaceutical and biotechnology industries to improve patient outcomes and quality of life, ... in analytical testing are being attributed to new regulatory requirements for all new ...
(Date:10/11/2017)... ... October 11, 2017 , ... At ... Purple announced Dr. Suneel I. Sheikh, the co-founder, CEO and chief research scientist ... has been selected for membership in ARCS Alumni Hall of Fame . ...
Breaking Biology Technology: