Navigation Links
Stowers Institute's Linheng Li Lab expands understanding of bone marrow stem cell niche
Date:12/5/2008

The Stowers Institute's Linheng Li Lab has identified the precise location of the bone marrow stem cell niche. The findings were published today in the Advance Online Publication of Nature.

The Linheng Li Lab collaborated with several of the Institute's support facilities to develop a new technology ex vivo Imaging of Stem Cells, or EVISC to monitor the dynamic behavior of stem cells. This technology enabled the team to track the homing of hematopoietic stem cells after being transplanted in mice. The findings build on the Linheng Li Lab's 2003 discovery of the hematopoietic stem cell (HSC) niche (Zhang, et al. in the October 23, 2003 issue of Nature).

"Using the EVISC technology, we were able to confirm our 2003 findings that HSCs tend to home to the inner bone surface," said Yucai Xie, Predoctoral Researcher and co-equal first author on the paper. "Additionally, we were able to resolve a debate in the field about whether the bone-forming niche or the blood-vessel-forming niche actually nurtures HSCs. Surprisingly, we revealed that the inner bone surface forms a special zone that includes both osteoblastic and endothelial components. This HSC zone maintains HSCs in their resting state and promotes HSC expansion in response to bone marrow stressors, such as irradiation."

Tong Yin, Ph.D., Postdoctoral Research Fellow, is also a co-equal first author on the paper.

A better understanding of the HSC niche may lead to more effective bone marrow transplants since a more precise understanding of the microenvironment that nurtures these therapeutically valuable cells will give physicians greater control over the entire process.

"The new technique developed in this study may have a variety of applications including monitoring other types of cells in low population numbers in vivo," said Winfried Wiegraebe, Ph.D., Director of Advanced Instrumentation and Physics, who provided the key assistance in the two-photon microscopic experiments.

"EVISC technology will allow us to study HSC lineage commitment in vivo," said Linheng Li, Ph.D., Investigator and senior author on the paper. "Furthermore, we will be able to use this technology to study leukemia (and other cancer) stem cells to better understand whether they use the same or different niches that normal stem cells use, and even to evaluate drug resistance and treatment responses. This is an exciting new avenue for our work."


'/>"/>

Contact: Marie Jennings
mfj@stowers-institute.org
816-926-4015
Stowers Institute for Medical Research
Source:Eurekalert

Related biology news :

1. Stowers Institutes Xie Lab demonstrates dual intrinsic and extrinsic control of stem cell aging
2. Stowers Institutes Hawley Lab identifies factors responsible for restart of meiotic cycle
3. Stowers Proteomics Center devises method for assigning probabilities to human protein interactions
4. Stowers Institute researchers identify gene linked to vertebral defects in patient populations
5. Stowers Institutes Shilatifard Lab identifies new role for factor critical to transcription
6. Stowers Institutes Workman Lab discovers novel histone demethylase protein complex
7. National Institutes of Health award Williams professor $217,710 research grant
8. New study spotlights National Institutes of Health grant outcomes for clinical research
9. Ossur -- leading orthopedic pioneer - expands network to Asia
10. Monsanto expands sponsorship for Peking-Yale Joint Agrobiotechnology Center
11. DHS Expands Biometrics-at-Sea Program to the Florida Straits
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/21/2016)... , June 21, 2016 NuData ... the new role of principal product architect and ... the director of customer development. Both will report ... technical officer. The moves reflect NuData,s strategic growth ... response to high customer demand and customer focus ...
(Date:6/9/2016)... an innovation leader in attendance control systems is proud to announce the introduction of ... make sure the right employees are actually signing in, and to even control the ... ... ... ...
(Date:6/2/2016)... 2, 2016 The Department of Transport ... the 44 million US Dollar project, for the , ... including Personalization, Enrolment, and IT Infrastructure , to ... production and implementation of Identity Management Solutions. Numerous renowned international ... Decatur was selected for the most compliant ...
Breaking Biology News(10 mins):
(Date:12/2/2016)... ... , ... DrugDev believes the only way to achieve real change ... three tenets were on display at the 2nd Annual DrugDev User Summit (hosted by ... and site organizations to discuss innovation and the future of clinical research. , ...
(Date:12/2/2016)... December 2, 2016 The immunohistochemistry (IHC) ... at a CAGR of 7.3% during the forecast period of 2016 ... diagnostic laboratories segment accounted for the largest share of immunohistochemistry (IHC) ... , ... global immunohistochemistry (IHC) market spread across 225 pages, profiling 10 companies ...
(Date:11/30/2016)... TORONTO , Nov. 30, 2016 /PRNewswire/ - Portage ... Canadian Securities Exchange: PBT.U), is excited to announce ... company focused on developing preclinical ophthalmology assets through ... a potent anti-inflammatory created by Portage Pharmaceuticals Limited ... patients with ocular surface and anterior segment diseases. ...
(Date:11/30/2016)... BEIJING , Nov. 30, 2016 Novogene ... services and solutions with cutting edge next-generation sequencing (NGS) ... a USD $75 Million [515 Million RMB] B round ... Capital Management ( Shenzhen ) Co., Ltd. ... Innovation") and Shanghai Sigma Square Investment Center LP ("Sigma ...
Breaking Biology Technology: