Navigation Links
Stowers Institute's Linheng Li Lab expands understanding of bone marrow stem cell niche

The Stowers Institute's Linheng Li Lab has identified the precise location of the bone marrow stem cell niche. The findings were published today in the Advance Online Publication of Nature.

The Linheng Li Lab collaborated with several of the Institute's support facilities to develop a new technology ex vivo Imaging of Stem Cells, or EVISC to monitor the dynamic behavior of stem cells. This technology enabled the team to track the homing of hematopoietic stem cells after being transplanted in mice. The findings build on the Linheng Li Lab's 2003 discovery of the hematopoietic stem cell (HSC) niche (Zhang, et al. in the October 23, 2003 issue of Nature).

"Using the EVISC technology, we were able to confirm our 2003 findings that HSCs tend to home to the inner bone surface," said Yucai Xie, Predoctoral Researcher and co-equal first author on the paper. "Additionally, we were able to resolve a debate in the field about whether the bone-forming niche or the blood-vessel-forming niche actually nurtures HSCs. Surprisingly, we revealed that the inner bone surface forms a special zone that includes both osteoblastic and endothelial components. This HSC zone maintains HSCs in their resting state and promotes HSC expansion in response to bone marrow stressors, such as irradiation."

Tong Yin, Ph.D., Postdoctoral Research Fellow, is also a co-equal first author on the paper.

A better understanding of the HSC niche may lead to more effective bone marrow transplants since a more precise understanding of the microenvironment that nurtures these therapeutically valuable cells will give physicians greater control over the entire process.

"The new technique developed in this study may have a variety of applications including monitoring other types of cells in low population numbers in vivo," said Winfried Wiegraebe, Ph.D., Director of Advanced Instrumentation and Physics, who provided the key assistance in the two-photon microscopic experiments.

"EVISC technology will allow us to study HSC lineage commitment in vivo," said Linheng Li, Ph.D., Investigator and senior author on the paper. "Furthermore, we will be able to use this technology to study leukemia (and other cancer) stem cells to better understand whether they use the same or different niches that normal stem cells use, and even to evaluate drug resistance and treatment responses. This is an exciting new avenue for our work."


Contact: Marie Jennings
Stowers Institute for Medical Research

Related biology news :

1. Stowers Institutes Xie Lab demonstrates dual intrinsic and extrinsic control of stem cell aging
2. Stowers Institutes Hawley Lab identifies factors responsible for restart of meiotic cycle
3. Stowers Proteomics Center devises method for assigning probabilities to human protein interactions
4. Stowers Institute researchers identify gene linked to vertebral defects in patient populations
5. Stowers Institutes Shilatifard Lab identifies new role for factor critical to transcription
6. Stowers Institutes Workman Lab discovers novel histone demethylase protein complex
7. National Institutes of Health award Williams professor $217,710 research grant
8. New study spotlights National Institutes of Health grant outcomes for clinical research
9. Ossur -- leading orthopedic pioneer - expands network to Asia
10. Monsanto expands sponsorship for Peking-Yale Joint Agrobiotechnology Center
11. DHS Expands Biometrics-at-Sea Program to the Florida Straits
Post Your Comments:
(Date:11/26/2015)... Research and Markets ( ) has announced the ... and Patent Infringement Risk Analysis" report to their ... Fingerprint sensors using capacitive technology represent a fast ... Idex forecasts an increase of 360% of the number ... the fingerprint sensor market between 2014 and 2017 (source ...
(Date:11/20/2015)... , November 20, 2015 NXTD ... focused on the growing mobile commerce market and creator ... Gino Pereira , was recently interviewed on The ... air on this weekend on Bloomberg Europe , ... . --> NXTD ) ("NXT-ID" or the ...
(Date:11/19/2015)... , Nov. 19, 2015  Based on its in-depth ... Sullivan recognizes BIO-key with the 2015 Global Frost & ... Frost & Sullivan presents this award to the company ... to the needs of the market it serves. The ... meets and expands on customer base demands, the overall ...
Breaking Biology News(10 mins):
(Date:11/25/2015)... , November 25, 2015 ... Research Report is a professional and in-depth study ...      (Logo: ) , ... of the industry including definitions, classifications, applications and ... provided for the international markets including development trends, ...
(Date:11/24/2015)... Nov. 24, 2015 Halozyme Therapeutics, Inc. (NASDAQ: HALO ... New York on Wednesday, December 2 at ... , president and CEO, will provide a corporate overview. ... at 1:00 p.m. ET/10:00 a.m. PT . ... will provide a corporate overview. --> th Annual ...
(Date:11/24/2015)... Inc., a worldwide provider of clinical research services headquartered in ... has set a new quarterly earnings record in Q3 of 2015.  ... Q3 of 2014 to Q3 of 2015.   ... the establishment of an Asia-Pacific office to ... and Mexico , with the establishment ...
(Date:11/24/2015)... 24, 2015 --> ... report released by Transparency Market Research, the global non-invasive ... CAGR of 17.5% during the period between 2014 and ... Global Industry Analysis, Size, Volume, Share, Growth, Trends and ... testing market to reach a valuation of US$2.38 bn ...
Breaking Biology Technology: