Navigation Links
Stowers Institute's Hawley Lab identifies factors responsible for restart of meiotic cycle
Date:12/4/2007

The Stowers Institutes Hawley Lab has identified a pair of proteins that work in concert to restart the meiotic cycle of oocytes following a natural period of dormancy.

The Hawley Lab has described the dual actions of these two proteins as the Sleeping Beauty Kiss that awakens the long-dormant egg, allowing for production of a mature oocyte ready for fertilization. The findings appear in the Dec. 4, 2007 issue of PLoS Biology.

The long period of dormancy that interrupts the process that parses out the correct number of chromosomes is characteristic of female meiosis. The cells that will become oocytes in human females develop during fetal development and begin the actual process of meiosis before birth, but the oocytes remain in a suspended state until the female reaches sexual maturity.

Extended periods of dormancy may last many years in organisms like humans, but shorter periods of meiotic arrest can be found in simpler, more easily studied species like the fruit fly the model used by the Hawley Lab in this work. In the fruit fly, oocyte development is arrested for 3-4 days at exactly the same point in meiosis as in humans.

The long period of meiotic arrest has mystified biologists for over a century because it raises the question of just how the sleeping oocyte is reawakened. The Hawley Lab addressed this question and determined that there are two molecular solutions at play: the controlled expression of a protein that restarts the cell cycle and the inactivation of an inhibitory protein that had previously prevented the restart of meiosis.

This work led us to the conclusion that the restart of the meiotic cycle in Drosophila depends on two mechanisms, said Youbin Xiang, Ph.D., Research Specialist II and first author on the paper. First, the controlled expression of an activator, known as Polo kinase, and second, the presence of a regulatory protein called Matrimony, which binds to and physically inacti
'/>"/>

Contact: Marie Jennings
mfj@stowers-institute.org
816-926-4015
Stowers Institute for Medical Research
Source:Eurekalert

Page: 1 2

Related biology news :

1. Stowers Institutes Xie Lab demonstrates dual intrinsic and extrinsic control of stem cell aging
2. Study identifies warning signs of pregnancy danger
3. Study identifies genetic risk factor for rheumatoid arthritis, lupus
4. Study by Pittsburgh researchers identifies possible vaccine target for chlamydia
5. Breakthrough research identifies how cells from pigs may cure diabetes
6. Smithsonian identifies invasive crab species in Panama Canal expansion area
7. Smithsonian identifies invasive crab species in Panama Canal expansion area
8. New technology identifies warped fingerprints at warp speed
9. Study identifies pathway required for normal reproductive development
10. St. Jude identifies the specific cell that causes eye cancer, disproving long-held theory
11. Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/10/2014)... , Dec. 9, 2014 CIE San Diego ... that provides the connective tissue that enhances care coordination ... to easily share client-level information; earned a second $1 ... to organizations serving seniors aging in community and; will ... on December 11 th 4-6p. CIE ...
(Date:12/4/2014)... PALM BEACH GARDENS, Fla. , Dec. 3, ... identity management solutions, today announced that its DigitalPersona ... 4500 fingerprint readers have been deployed throughout ... Carolina , South Carolina ... network headquartered in Southern Pines, North ...
(Date:11/21/2014)... , Nov. 20, 2014 Strict laws ... efficiency are piloting the North American and European automotive ... accidents growing, gesture recognition systems that are intuitive and ... mark in the industry. New analysis ... Gesture Recognition Market in Europe ...
Breaking Biology News(10 mins):Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 2Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 3Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 4First Bank Partners with Crossmatch to Increase Log In Security 2First Bank Partners with Crossmatch to Increase Log In Security 3Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 2Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 3Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 4
... MD FASEB MARC (Maximizing Access to Research Careers) ... Society for the Study of Reproduction (SSR) Annual Meeting ... These awards are meant to promote the entry of ... of the basic science community and to encourage the ...
... systems work together to paralyze skeletal muscles during rapid eye ... 11 issue of The Journal of Neuroscience . The ... including narcolepsy, tooth grinding, and REM sleep behavior disorder. ... recalled dreams occur your eyes continue to move but ...
... has been awarded a grant expected to total more ... (NIH) National Institute of Allergy and Infectious Diseases (NIAID). ... vaccine against HIV and the disease it causes, AIDS. ... vaccine is urgently needed to slow and eventually eliminate ...
Cached Biology News:Study identifies how muscles are paralyzed during sleep 2Scripps Research Institute wins $77 million to develop AIDS vaccine center 2Scripps Research Institute wins $77 million to develop AIDS vaccine center 3
(Date:12/24/2014)... BOTHELL, Wash. , Dec. 24, 2014   ... a leading developer, manufacturer and marketer of proprietary clinical ... media and precision thermal shipping products ... announced that it will hold its 2015 Annual Meeting ... Because the expected date for the Annual ...
(Date:12/24/2014)... SoundConnect’s 2015 ... introduce cutting edge communication technology, provide continued ... platform upgrades. This webinar series demonstrates online ... their quest to leverage web conferencing’s most ... SoundConnect’s Marketing Manager, Seanna Baumgartner, “Our webinars ...
(Date:12/24/2014)... Tenn. (PRWEB) December 23, 2014 Nashville ... was elected treasurer for the American Society for ... advancing knowledge and research in reproductive medicine. In ... a seat on the executive board and will have ... , Dr. Hill has actively supported ASRM since 1984 ...
(Date:12/24/2014)... AUSTIN, Texas , Dec. 23, 2014 /PRNewswire/ ... solutions company focused on gynecologic disease, announced today ... W. Schuler , Birchview Fund LLC and several ... million of unregistered shares of Vermillion,s common stock ... common stock in a private placement.  ...
Breaking Biology Technology:BioLife Solutions Sets Date for Annual Meeting of Stockholders 2SoundConnect Launches Leading Edge Business Communications Webinar Series 2SoundConnect Launches Leading Edge Business Communications Webinar Series 3Nashville Fertility Center Announces Dr. George A. Hill Selected to Serve as ASRM Treasurer for 2014-15 2Nashville Fertility Center Announces Dr. George A. Hill Selected to Serve as ASRM Treasurer for 2014-15 3Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 2Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 3Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 4Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 5
... Treat Patients with Cardiovascular and Digestive Disease ... ... Today the Medical University,of South Carolina (MUSC) opens the doors of ... with cardiovascular,and digestive disease problems. Ashley River Tower marks the first ...
... WYE ),announced today that it will present ... Medical Device Conference on Thursday,February 7, 2008 at ... be,Geno Germano, President, U.S. Pharmaceuticals & Women,s Health ... live for investors at, http://www.wyeth.com and available ...
... February 4 Acrongenomics, Inc. (OTC:,AGNM) is pleased ... interest in,Molecular Vision Limited, on a fully diluted ... Vision for working capital and to further develop,its ... easy-to-use credit-card sized,devices for medical testing that will ...
Cached Biology Technology:Medical University of South Carolina Opens State-of-the-Art Facility 2Medical University of South Carolina Opens State-of-the-Art Facility 3Medical University of South Carolina Opens State-of-the-Art Facility 4Wyeth to Present at the Merrill Lynch 2008 Global Pharmaceutical, Biotechnology and Medical Device Conference 2Acrongenomics Acquires Equity Stake in Molecular Vision 2Acrongenomics Acquires Equity Stake in Molecular Vision 3
Sf21 cells derived from Spodoptera frugiperda ovarian cells are recommended for high-level production of recombinant proteins. Higher expression levels of some proteins are seen due to the larger ce...
Sf9 cells derived from Spodoptera frugiperda ovarian cells (Sf21 cells) are commonly used to isolate and propagate recombinant AcMNPV viral stocks and to produce recombinant proteins....
... SilverQuest Silver Staining Kit is uniquely ... sensitivity with minimal protein modification for ... spectrometry problems associated with traditional silver ... kit because the reagents used do ...
... Medium is formuatled for the growth ... and Sf21 cells. Grace's Insect Mediu, ... it does not contain lactalbumin hydrosylate, ... transfection. Grace's Insect Medium, Supplemented is ...
Biology Products: