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Story tips from the Department of Energy's Oak Ridge National Laboratory, September 2008
Date:9/12/2008

the Natural Science and Engineering Council of Canada. Contact: Ron Walli, (865) 576-0226; wallira@ornl.gov]

PHYSICS -- Quadrupole DNA sequencing . . .

Research at Oak Ridge National Laboratory is exploring how a system of nanotubes, magnets and electrically charged particles could lead to a quicker, cheaper way to conduct DNA sequencing. The project headed by Predrag S. Krstic of ORNL's Physics Division will use a nanoscale quadrupole Paul trap, a component of a mass spectrometer that captures ions in an electromagnetic field, to develop a high speed DNA sequencing device. Using the Paul trap to manipulate DNA between nanotube electrodes could result in a lower cost alternative to nanopore sequencing, which works by moving strands of DNA through a small hole in a membrane. Most of the work is being conducted in collaboration with the Mark A. Reed Research Group of Yale University. The research is funded by $722,000 from the National Human Genome Research Institute, part of the National Institutes of Health. The program seeks to cut the cost of whole-genome sequencing from millions of dollars to $1,000 or less, making individual genome sequencing cost-feasible for routine medical care. [Contact: Mike Bradley, (865) 576-9553; bradleymk@ornl.gov]


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Contact: Ron Walli
wallira@ornl.gov
865-576-0226
DOE/Oak Ridge National Laboratory
Source:Eurekalert

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