Navigation Links
Story of lymphatic system expands to include chapter on valve formation
Date:11/14/2011

cells destined to become lymphatic endothelial cells (LECs) when they leave the developing veins and migrate throughout the body.

The investigators also showed the Coup-TFII gene is essential to the process. The Coup-TFII protein binds to the promoter region of the Prox1 gene. The binding switches on production of the Prox1 protein that is required to create and maintain the lymphatic system. The newer research builds on that earlier work from Oliver's laboratory. The latest study focused on the lymphovenous valves. These valves are found at just two locations in the body, on either side of the chest just under the clavicle bone where the lymphatic vessels intersect with the subclavian and internal jugular veins.

Working in mice, investigators discovered that these lymphovenous valves form from a newly identified subtype of endothelial cell found in developing veins. Like the LECs that form the lymphatic system, the newly identified endothelial cells make Prox1. But while the LECs leave the veins and migrate throughout the body, these endothelial cells stay put to form the lymphovenous valves.

Researchers demonstrated the process requires two copies of the Prox1 gene. That ensures adequate levels of the Coup-TFII-Prox1 complex and with it enough Prox1 to build and maintain the lymphatic system. Mice engineered to carry a single copy of Prox1 either did not survive or were born without lymphovenous and venous valves.

"If you have only one copy of Prox1 you are going to have a reduction in the Coup-TFII Prox1 complex and so a dramatic reduction in the number of cells available to build the lymphatic system. That explains the defects we see," Srinivasan said.


'/>"/>

Contact: Summer Freeman
summer.freeman@stjude.org
901-595-3061
St. Jude Children's Research Hospital
Source:Eurekalert

Page: 1 2

Related biology news :

1. Story tips from the US Department of Energys Oak Ridge National Laboratory, November 2011
2. Story tips from the Department of Energys Oak Ridge National Laboratory, October 2011
3. What makes rainforests unique? History, not ecology
4. Using human genomes to illuminate the mysteries of early human history
5. Mouse genome sequences reveal variability, complex evolutionary history
6. Sea smarts: Scientists reconstruct evolutionary history of mollusks
7. The remarkable history of medicines battle with infectious diseases
8. Mass. Eye and Ear awarded largest NIH grant in hospital’s history
9. BUSM professor authors book on how knowledge about genes and family history can save lives
10. Lessons learned from the 2 worst oils spills in US history
11. Natural History Museum of Los Angeles County makes scientific history with pregnant plesiosaur
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/23/2014)... manufacture their own "antifreeze" proteins to survive in ... side effect, researchers funded by the National Science ... accumulate inside their bodies resist melting even when ... to be an undesirable consequence of the evolution ... University of Oregon doctoral student Paul Cziko, who ...
(Date:9/23/2014)... When the body forms new tissues during ... communicate with each other. For years, scientists believed ... researchers at Carnegie Mellon University and the University ... mechanical communication is equally if not more ... of the Proceedings of the National Academy ...
(Date:9/23/2014)... have scoured cow rumens and termite guts for microbes ... the production of next-generation biofuels, but some of the ... lower intestine, researchers report. , Their study , ... of Sciences , is the first to use biochemical ... human gut can digest fiber, breaking it down into ...
Breaking Biology News(10 mins):Antifreeze proteins in Antarctic fish prevent both freezing and melting 2Antifreeze proteins in Antarctic fish prevent both freezing and melting 3The mechanics of tissue growth 2Search for better biofuels microbes leads to the human gut 2Search for better biofuels microbes leads to the human gut 3
... this morning showed the "tropical trio": Tropical Storm Karl ... central Atlantic, and a waning Hurricane Julia in the ... Category 4 Hurricane status, and is currently a Category ... shear, cooler sea surface temperatures and warmer cloud top ...
... Were our early mammalian ancestors vegetarians, vegans or ... of early mammalians because current fossil analysis provides too ... size of chips in tooth fossils can help determine ... Prof. Herzl Chai of Tel Aviv University,s School of ...
... 2010 For Immediate Release Scripps Research Institute Professor ... grant as part of a National Institutes of Health (NIH) ... DNA sequencing technologies, which could enable biomedical researchers and health ... With the new grant, funded by the NIH,s Human Genome ...
Cached Biology News:GOES-13 sees a weaker Hurricane Julia in the 'tropical trio' 2A chip off the early hominin tooth 2Scripps research team wins $5.1 million to develop DNA sequencing technology 2
(Date:9/23/2014)... -- News Facts , As the ... to genome-based research for human health and disease, the ... bite out of oral cancer with its world-class research into ... with the help of state-of-the-art solution comprising block, ... , To fuel its cutting-edge cancer research, the institute has ...
(Date:9/23/2014)... , Sept. 23, 2014   GenoSpace , ... comprehensive suite of tools to enable the broad use ... announced that it has been awarded Phase I of ... from the National Institutes of Health (NIH) to enable ... Logo - http://photos.prnewswire.com/prnh/20140922/147649 ...
(Date:9/23/2014)... September 23, 2014 Dr. Williams says, ... book on healthcare offers a three phase process that ... healthcare delivery system that would go far beyond anything ... regarding the delivery of healthcare.” , “Every effort to ... failed to provide discernable progress throughout that system because ...
(Date:9/22/2014)... who were treated with a statin in the hospital ... likely to survive than those who were not, according ... . This study was conducted by the same researchers ... can improve survival in victims of ischemic stroke., Ischemic ... a blood vessel that blocks blood from reaching areas ...
Breaking Biology Technology:National Institute of Biomedical Genomics (NIBMG) Deploys DataDirect Networks Storage to Achieve Significant Performance Improvement in World-Class Genomics Research and Collaboration for Oral Cancer 2National Institute of Biomedical Genomics (NIBMG) Deploys DataDirect Networks Storage to Achieve Significant Performance Improvement in World-Class Genomics Research and Collaboration for Oral Cancer 3National Institute of Biomedical Genomics (NIBMG) Deploys DataDirect Networks Storage to Achieve Significant Performance Improvement in World-Class Genomics Research and Collaboration for Oral Cancer 4National Institute of Biomedical Genomics (NIBMG) Deploys DataDirect Networks Storage to Achieve Significant Performance Improvement in World-Class Genomics Research and Collaboration for Oral Cancer 5GenoSpace Awarded Fast Track SBIR Grant to Enable Data Access and Cohort Construction for Biorepositories 2Dr. Ira Williams Offers the Healthcare Solution Necessary for Patient Safety Improvement 2Statin use during hospitalization for hemorrhagic stroke associated with improved survival 2
... The American Chamber of Commerce in Spain (AmChamSpain) ... Victor Grifols Roura, as the winner of its ... to recognize the international efforts of business leaders, ... responsible economic globalization. (Logo: http://photos.prnewswire.com/prnh/20110304/PH59473LOGO) ...
... -- Using minute graphite particles 1000 times smaller than the ... University hope to boost the efficiencyand profitabilityof solar power plants. ... more on rooftops, but they,re not necessarily the best solar ... they can use only a fraction of the sunlight that ...
... 2011 Neurocrine Biosciences, Inc. (NASDAQ: NBIX ) ... preliminary assessment of the initial cohort of Tardive Dyskinesia ... (VMAT2), NBI-98854. Based on this data, the Company is ... the U.S. Food and Drug Administration (FDA). ...
Cached Biology Technology:The American Chamber of Commerce in Spain Awards the Global Business Leader Award 2011 to Victor Grifols Roura, President and CEO of Grifols 2The American Chamber of Commerce in Spain Awards the Global Business Leader Award 2011 to Victor Grifols Roura, President and CEO of Grifols 3Nanoparticles improve solar collection efficiency 2Neurocrine Biosciences Announces Successful Phase IIa Clinical Trial for VMAT2 Inhibitor 2Neurocrine Biosciences Announces Successful Phase IIa Clinical Trial for VMAT2 Inhibitor 3Neurocrine Biosciences Announces Successful Phase IIa Clinical Trial for VMAT2 Inhibitor 4
...
... T4 DNA Ligase catalyzes the formation ... ATP between double-stranded DNAs with 3' hydroxyl ... DNA Ligase buffer optimizes ligation which can ... nucleic acids are not substrates for this ...
Bovine Renal Artery Smooth Muscle Cells (BRASMC) (>500,000 cells)...
... The Finnpipette BioControl is a ... technology. A complete liquid handling system ... twelve interchangeable tip cone modules. All ... tip cone modules fit one handle. ...
Biology Products: