Navigation Links
Story ideas from the Journal of Lipid Research
Date:1/10/2008

Metabolic syndrome, a collection of related abnormalities like hypertension, obesity, insulin resistance, and excess cholesterol, poses a major risk for developing heart disease and diabetes. Individuals with a genetic predisposition to high cholesterol (familial hyperlipidemia or FH) can be especially vulnerable to metabolic syndrome, but researchers have now found that blocking the enzyme stearoyl-CoA desaturase-1 (SCD1), which helps synthesize unsaturated fatty acids, greatly improves the profile of FH-mice affected by metabolic syndrome.

Previous mouse studies on SCD1 found that blocking this enzyme could reduce obesity in normal mice; Michael Hayden and colleagues wondered whether such a protective effect would extend to mice with excess cholesterol levels.

They mimicked FH in mice by knocking out the LDL receptor, causing a cholesterol buildup. When fed a high-fat Western diet, these mice develop obesity and diabetes in adulthood. However, when the researchers also knocked out SCD1, the mice improved dramatically, accumulating far less fat in their liver, which in turn led to fewer triglycerides in the blood, increased insulin sensitivity, and less weight gain. These results highlight that SCD1 might be a potential drug target for FH individuals who have developed other components of metabolic syndrome


'/>"/>

Contact: Nick Zagorski
nzagorski@asbmb.org
American Society for Biochemistry and Molecular Biology
Source:Eurekalert

Page: 1

Related biology news :

1. The surprising story of Charles Darwin and his homeopathic doctor
2. Story tips from the Department of Energys Oak Ridge National Laboratory, December 2007
3. Story ideas from the Journal of Lipid Research
4. Journal Sleep: Insomniacs are more likely to report a family history of the sleep disorder
5. Nanotechnology and the media: The inside story
6. Rebuilding the evolutionary history of HIV-1 unravels a complex loop
7. Story ideas from the Journal of Biological Chemistry
8. Story tips from the Department of Energys Oak Ridge National Laboratory, October 2007
9. Story ideas from Molecular & Cellular Proteomics
10. Microfossils disclose geologic history of eastern California
11. New study sheds light on Galápagos hawk evolutionary history
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2016)... , May 24, 2016 Ampronix facilitates superior patient care by providing ...  3D medical LCD display is the latest premium product recently added to the range ... ... ... Sony 3d Imaging- LCD Medical Display- Ampronix News ...
(Date:5/9/2016)... DUBAI , UAE, May 9, 2016 ... choice when it comes to expanding freedom for high ... Even in today,s globally connected world, there ... online conferencing system could ever duplicate sealing your deal ... are obtaining second passports by taking advantage of citizenship ...
(Date:4/26/2016)... India and LONDON ... Infosys Finacle, part of EdgeVerve Systems, a product ... and Onegini today announced a partnership to integrate ... solutions.      (Logo: http://photos.prnewswire.com/prnh/20151104/283829LOGO ... to provide their customers enhanced security to access ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... 23, 2016   Boston Biomedical , an ... designed to target cancer stemness pathways, announced that ... Orphan Drug Designation from the U.S. Food and ... cancer, including gastroesophageal junction (GEJ) cancer. Napabucasin is ... inhibit cancer stemness pathways by targeting STAT3, and ...
(Date:6/23/2016)... Prostate Cancer Foundation (PCF) is pleased to announce 24 new Young ... cancer. Members of the Class of 2016 were selected from a pool of ... More About the Class of 2016 PCF Young Investigators ... ... ...
(Date:6/23/2016)... ... June 23, 2016 , ... In a new case report published ... how a patient who developed lymphedema after being treated for breast cancer benefitted from ... the paradigm for dealing with this debilitating, frequent side effect of cancer treatment. ...
(Date:6/23/2016)... (PRWEB) , ... June 23, 2016 , ... ... is exhibiting at the Pennsylvania Convention Center and will showcase its product’s latest ... ClinCapture will also be presenting a scientific poster on Disrupting Clinical Trials in ...
Breaking Biology Technology: