Navigation Links
Story ideas from the Journal of Lipid Research
Date:8/27/2007

Frankfurt am Main, Germany; e-mail: huwiler@pki.unibe.ch


The following article is the fourth in a series of reviews on adipocyte biology or the biology of fat tissue. The other articles in the series will appear in future issues of the journal. All thematic review articles and can be accessed at: http://www.jlr.org/ (under Thematic Reviews).

* Understanding how obese fat cells work

In obese individuals, fat cells are bloated and inflamed because they receive too many nutrients, including lipids. In these cells, various components cannot work properly anymore and, instead, they activate new proteins to cope with the situation. One of the most challenged organelles in obese fat cells is a maze-like compartment called the endoplasmic reticulum (ER) that makes proteins and lipid droplets and senses the amount of nutrients that enter the cell.

Margaret F. Gregor and Gokhan S. Hotamisligil review current knowledge about how the ER works in fat cells and is modified in obesity. They show that when a fat cell receives too many nutrients, the ER is overwhelmed and triggers a process called the unfolded protein response (UPR). This process is one of many cellular responses that activate proteins that increase inflammation and can even result in the death of the cell. UPR also causes insulin resistance, a condition in which the production and function of insulin a hormone produced by the pancreas is impaired and blood sugar is too high.

The scientists show that by better understanding how the ER works, it may be possible to devise a therapy that enhances the function of the ER and maybe improve the health of obese people. Already, two molecules that protect the ER from obesity-related stress have shown some success in mice. Called PBA and TUDCA, the molecules decreased blood sugar and insulin levels and improved overall response to ins
'/>"/>

Contact: Pat Pages
ppages@asbmb.org
301-634-7366
American Society for Biochemistry and Molecular Biology
Source:Eurekalert

Page: 1 2 3 4 5

Related biology news :

1. Leprosy genome tells story of human migrations, French researchers report in Science
2. Can our genes tell the story of our divergence?
3. Divergent life history shapes gene expression in brains of salmon
4. Restaurant seafood prices since 1850s help plot marine harvests through history
5. Finding rewrites the evolutionary history of the origin of potatoes
6. Image of myosin-actin interaction revealed in cover story of Molecular Cell
7. Embryos tell story of Earths earliest animals
8. Underdogs in the understory: Study suggests nature favors rarer trees
9. Mouse to man: The story of chromosomes
10. Illinois pig to make history as source of first complete swine genome
11. History of human cannibalism eats away at researchers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... have explored two different ways that allow unprecedented ... the formation of oxygen molecules in photosynthesis. The ... journal Nature Communications . , "The new ... for water oxidation, which are key components for ... of solar energy in fuels like hydrogen, ethanol ...
(Date:7/11/2014)... under the normal circumstances, astrocytes participate in ... environment, and exhibit therapeutic and repairing effects ... studies have found that nerve cells differentiated ... have reduced viability, which produces influences on ... Kailuan General Hospital, Hebei United University, China ...
(Date:7/10/2014)... In Santa Fe, Albuquerque, and other major cities in ... watered with treated municipal wastewater rather than precious potable ... more than 40% of all golf courses receive treated ... courses. , Additionally, golf courses and homeowners alike ... nutrient in fertilizer is nitrate. A New Mexico State ...
Breaking Biology News(10 mins):Molecular snapshots of oxygen formation in photosynthesis 2'Tailored' water -- the latest in lawn care 2
... non-native mussels in the Great Lakes has caused ... two of the planet,s largest freshwater lakes, according ... The blitzkrieg advance of two closely related species ... of their life-supporting algae, resulting in a remarkable ...
... 2011 A natural hormone known to inhibit aging can ... researchers have demonstrated. Scientists led by Dr. Makoto Kuro-o, ... hormone Klotho suppressed both renal fibrosis a common complication ... The findings are available online in the Journal of ...
... warming may be the greatest challenge of the present generation. ... the average citizen often wonders what he or she can ... FROM GERMANY,S SUCCESS IN HARNESSING CLEAN ENERGY" (Prometheus Books, $19) ... in the making veteran science and technology journalist Bob ...
Cached Biology News:Invasive mussels causing massive ecological changes in Great Lakes 2Invasive mussels causing massive ecological changes in Great Lakes 3Anti-aging hormone Klotho inhibits renal fibrosis, cancer growth 2Switching to solar 2
(Date:7/10/2014)... Not even geckos and spiders can sit upside down forever. ... have demonstrated this in an article just published in ... industrial benefit. , Geckos and spiders that seem to be ... have fascinated researchers worldwide for many years. We will soon ... same way as the gecko,s foot. But the fact is, ...
(Date:7/10/2014)... University of Illinois at Urbana-Champaign provides new insights ... spin and heat at the nanoscale, and addresses ... data storage and information processing. , "Electrons ... In a typical charge current, electrons, spin-angular-momentum is ... David Cahill, a professor of materials science and ...
(Date:1/15/2014)... akin to assembling a club sandwich at the ... researchers have succeeded in crafting a uniform, multi-walled ... foam commonly used in upholstered furniture and other ... polyurethane foam was reduced 35 percent compared with ...
(Date:1/15/2014)... Ill. , Jan. 15, 2014  Bill Jacobs Automotive, a ... , is teaming up with the Heartland Blood Center and ... blood drive. The drive takes place Saturday, Jan. 18 at ... - 2 p.m. (Photo: http://photos.prnewswire.com/prnh/20140115/MN46637 )  ...
Breaking Biology Technology:Even geckos can lose their grip 2University of Illinois study advances limits for ultrafast nano-devices 2Layered security: Carbon nanotubes promise improved flame-resistant coating 2Join the Bill Jacobs Auto blood drive and receive a free oil change 2
... of Convertible Preferred Stock -, DALLAS, Jan. ... announced today that it has executed agreements,for $2.7 ... into agreements,with institutional and accredited investors to purchase ... the Company,s Series A Convertible,Preferred Stock. This equity ...
... Healionics Corporation, a,provider of tissue regeneration and ... it has raised $1.7 million,in a Series A ... Carl Lombardi, former CEO of SpaceLabs Medical and ... & Rejuvenation Center., "We are pleased to ...
... in cash at year end; no equity financings expected ... disease programs to continue in,2008; latest data for all ... - Expansion of research and development investment ... lysosomal diseases in 2008, CRANBURY, N.J., Jan. 29 ...
Cached Biology Technology:Access Pharmaceuticals Announces $2.7 Million New Equity 2Access Pharmaceuticals Announces $2.7 Million New Equity 3Healionics Corporation Completes Series A Financing 2Amicus Therapeutics Announces Fourth Quarter and Full Year 2007 Financial Results & Program Advancements 2Amicus Therapeutics Announces Fourth Quarter and Full Year 2007 Financial Results & Program Advancements 3Amicus Therapeutics Announces Fourth Quarter and Full Year 2007 Financial Results & Program Advancements 4Amicus Therapeutics Announces Fourth Quarter and Full Year 2007 Financial Results & Program Advancements 5Amicus Therapeutics Announces Fourth Quarter and Full Year 2007 Financial Results & Program Advancements 6Amicus Therapeutics Announces Fourth Quarter and Full Year 2007 Financial Results & Program Advancements 7Amicus Therapeutics Announces Fourth Quarter and Full Year 2007 Financial Results & Program Advancements 8Amicus Therapeutics Announces Fourth Quarter and Full Year 2007 Financial Results & Program Advancements 9Amicus Therapeutics Announces Fourth Quarter and Full Year 2007 Financial Results & Program Advancements 10Amicus Therapeutics Announces Fourth Quarter and Full Year 2007 Financial Results & Program Advancements 11Amicus Therapeutics Announces Fourth Quarter and Full Year 2007 Financial Results & Program Advancements 12Amicus Therapeutics Announces Fourth Quarter and Full Year 2007 Financial Results & Program Advancements 13Amicus Therapeutics Announces Fourth Quarter and Full Year 2007 Financial Results & Program Advancements 14