Navigation Links
Story ideas from the Journal of Biological Chemistry
Date:1/14/2008

COX-2 inhibitors like Celecoxib have come under scrutiny lately due to adverse cardiovascular side-effects stemming from COX-2 reduction. In both fruit fly and rat models, researchers reveal another adverse effect of Celecoxib; this drug can induce arrhythmia. More interestingly, this effect is independent of the COX-2 enzyme.

Satpal Singh and colleagues tested various Celecoxib doses on the heart rate of Drosophila, a good model for human cardiac pharmacology. To their surprise, administering 3 m Celecoxib (not much higher than the plasma levels in humans taking the drug) reduced heart rate and increased beating irregularities, while 30 m was enough to stop the heart within a minute.

The surprise arises from the fact that Drosophila do not have COX-2 enzymes. Rather, Celecoxib could directly inhibit the potassium channels that help generate the electric current that drives heartbeat.

The researchers could achieve similar heart-stopping results in rat cardiac cells, whereas aspirin, another potent COX-2 inhibitor, had no effect, confirming that another mechanism is at work. The drug also inhibited rat and human potassium channels expressed in a human cell line.

Singh and colleagues point out that since these arrhythmia effects bypass COX-2, it is unclear if other COX-2 inhibitors would yield similar results. They also stress it is too early to speculate on human effects, although their results suggest Drosophila are a valuable tool to investigate other COX-2 drugs.


'/>"/>

Contact: Nick Zagorski
nzagorski@asbmb.org
American Society for Biochemistry and Molecular Biology
Source:Eurekalert  

Page: 1

Related biology news :

1. Story ideas from the Journal of Lipid Research
2. The surprising story of Charles Darwin and his homeopathic doctor
3. Story tips from the Department of Energys Oak Ridge National Laboratory, December 2007
4. Story ideas from the Journal of Lipid Research
5. Journal Sleep: Insomniacs are more likely to report a family history of the sleep disorder
6. Nanotechnology and the media: The inside story
7. Rebuilding the evolutionary history of HIV-1 unravels a complex loop
8. Story ideas from the Journal of Biological Chemistry
9. Story tips from the Department of Energys Oak Ridge National Laboratory, October 2007
10. Story ideas from Molecular & Cellular Proteomics
11. Microfossils disclose geologic history of eastern California
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Story ideas from the Journal of Biological Chemistry
(Date:1/22/2015)... Jan. 22, 2015 Research and Markets ... the "Global Wearable Technologies Market and Applications, ... Trends and Forecast 2014-2020" report to their ... smart devices that can be worn on the ...
(Date:1/22/2015)... Jan. 22, 2015 Infinisource has launched its new NXG ... model. The G2 sets a higher standard for collecting attendance ... management solution. With plug-and-play installation, touch screen interface and seamless ... a robust time collection solution for the small to mid-size ...
(Date:12/22/2014)... (NASDAQ: NXTD and NXTDW) ("NXT-ID" or the ... commerce market, announces it has retained famous pickpocket, entertainer and ... CES debut of the Wocket™ biometric smart wallet.  ... booth January 6th and 7 th , 2015, demonstrating some ...
Breaking Biology News(10 mins):Global Wearable Technologies Market and Applications, Opportunities, Industry Analysis, Segmentation, Size, Growth, Share, Overview, Trends and Forecast 2014-2020 2Infinisource's NXG series sets new time clock standard 2NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 2NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 3NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 4
... information can go a long way when it comes to ... led by scientist John Orrock of the University of Wisconsin-Madison ... on the Channel Islands off the southern coast of California. ... by rodents--called Sin Nombre virus. Results of the study ...
... Vobile, a leading provider of video content identification ... television company, announced today that it has begun ... through upgrades to its video fingerprinting system—the biggest ... management platform, the first to be developed by ...
... family members gather at a picnic in your backyard, there may ... barbecue. When flies visit your party, be glad they don,t ... And those are just the ones we know about. An ... who have recently researched the fly family tree -- one of ...
Cached Biology News:Study of deer mice on California's Channel Islands provides new information on hantavirus 2Study of deer mice on California's Channel Islands provides new information on hantavirus 3Youku Upgrades Fingerprinting System for Tougher Copyright Protection Measures 2Youku Upgrades Fingerprinting System for Tougher Copyright Protection Measures 3Too many relatives ruining your picnic? Be glad the flies don't invite their cousins 2
(Date:1/22/2015)... Rootstown, OH (PRWEB) January 22, 2015 Crystal ... announced today that it has received AOAC-PTM Certifications for the ... O111, O121, and O145; collectively referred to as STEC or ... at 1 colony forming unit (cfu) per 325 g of ...
(Date:1/22/2015)... 22, 2015 zFlo Motion , a ... announce an exciting product from a new partner. STT-Systems ... over the past 15 years, with offerings in the optical-motion ... 3D IMU system (inertial measurement unit), iSen, is opening eyes ...
(Date:1/22/2015)... DE (PRWEB) January 22, 2015 Controlled ... Pistoia Alliance, which helps companies check the legal requirements ... to expand to China. , As their international ... are globally adopting software solutions built as a result ...
(Date:1/22/2015)... 22, 2015 Diagenode, Inc., a ... the Bioruptor® and complete solutions for epigenetics research, ... immunoprecipitation, alleviating the need for manual processing. The ... for ChIP of histones or transcription factors and ...
Breaking Biology Technology:Crystal Diagnostics Awarded AOAC-PTM Accreditation for the Rapid Detection of “Big 6” E.coli Food Pathogens 23D Motion Capture Just Got Easy 2Global Compliance Service for Controlled Substances to Expand to China 2Diagenode Launches Unique Semi-Automated Solution for Chromatin Immunoprecipitation 2
... , ... , , , Slab ... the separated bands,of an unknown sample to a known,standard (size ... estimated. The Agilent,2100 bioanalyzer is an instrument,which utilizes LabChip,technology to ...
... , , , ... , , , , ... isolated by microdissection has,become a very popular method for analyzing cellular ... of research and clinical applications.,Laser-assisted microdissection allows isolation of RNA from ...
... , , ... , , , Whereas in ... molecules, the development of soft ionization methods,such as matrix-assisted laser desorption/ionization ... the analysis of proteins up to 300 kDa using MS has,become ...
Cached Biology Technology:High resolution DNA analysis with the,DNA 500 and DNA 1000 LabChip kits 2High resolution DNA analysis with the,DNA 500 and DNA 1000 LabChip kits 3High resolution DNA analysis with the,DNA 500 and DNA 1000 LabChip kits 4High resolution DNA analysis with the,DNA 500 and DNA 1000 LabChip kits 5Quality assurance of RNA derived from,laser microdissected tissue samples,obtained by the PALM MicroBeam System,using the RNA 6000 Pico LabChip kit. 2Quality assurance of RNA derived from,laser microdissected tissue samples,obtained by the PALM MicroBeam System,using the RNA 6000 Pico LabChip kit. 3Quality assurance of RNA derived from,laser microdissected tissue samples,obtained by the PALM MicroBeam System,using the RNA 6000 Pico LabChip kit. 4Quality assurance of RNA derived from,laser microdissected tissue samples,obtained by the PALM MicroBeam System,using the RNA 6000 Pico LabChip kit. 5Quality assurance of RNA derived from,laser microdissected tissue samples,obtained by the PALM MicroBeam System,using the RNA 6000 Pico LabChip kit. 6Quality assurance of RNA derived from,laser microdissected tissue samples,obtained by the PALM MicroBeam System,using the RNA 6000 Pico LabChip kit. 7Quality assurance of RNA derived from,laser microdissected tissue samples,obtained by the PALM MicroBeam System,using the RNA 6000 Pico LabChip kit. 8Using the Agilent 2100 bioanalyzer for,quality control of protein samples prior to,MS-analysis 2Using the Agilent 2100 bioanalyzer for,quality control of protein samples prior to,MS-analysis 3Using the Agilent 2100 bioanalyzer for,quality control of protein samples prior to,MS-analysis 4Using the Agilent 2100 bioanalyzer for,quality control of protein samples prior to,MS-analysis 5
... The new Vivaspin 2 bridges the ... ml centrifugal concentrators. This device combines the ... low internal surface and membrane area for ... ,Available with a choice of PES, Cellulose ...
... Recognizes VAMP-2 (Vesicle-Associated Membrane Protein ... does not share homology with ... It is expected that ... with human, Macaca multata and ...
... Monoamine Transporter 2 (VMAT2). An antibody made ... major band at ~55 kDa in postnuclear ... not in wild type cells (2). Some ... weight, were also detected and remain unaffected ...
Immunogen for A300-655A was a phosphorylated synthetic peptide, which represented a portion of human RNA Polymerase II (GeneID 5430) around serine 5 of the C-terminal repeat YSPTSPS....
Biology Products: