Navigation Links
Story ideas from the Journal of Biological Chemistry

Fat Hormone may Contribute to Longevity

Both humans and mice that manage to live to a ripe, old age show a clear change in their glucose metabolism, but it's unclear whether this change alone can increase lifespan. Using a mouse model of longevity, Terry Combs and colleagues report that changes in metabolism can indeed increase longevity. They demonstrated that long-lived Snell dwarf mice burn less glucose and more fatty acids during periods of fasting, and as a result produce fewer free radicals.

The key to this switch may be adiponectin, a hormone produced by fat cells that helps lower glucose production and stimulates cells to use fat for energy instead. The researchers found that Snell mice had three times as much adiponectin in their blood as control mice; Snell mice also had fewer triglycerides in their cells, indicative of higher fat metabolism.

The benefit of burning fats instead of glucose for energy is that it produces fewer oxygen radicals which can damage cells and exacerbate the effects of aging. Confirming this, Combs and colleagues found far less free radical damage, measured as the frequency of a chemical modification on protein known as carbonyl groups, in Snell mice than controls.

Article: Low utilization of circulating glucose after food withdrawal in Snell dwarf mice by Natasha L. Brooks, Chad M. Trent, Carl F. Raetzsch, Kevin Flurkey, Gunnar Boysen, Michael T. Perfetti, Yo-Chan Jeong, Simon Klebanov, Kajal B. Patel, Valerie R. Khodush, Lawrence L. Kupper, David Carling, James A. Swenberg, David E. Harrison, and Terry P. Combs

CORRESPONDING AUTHOR: Terry Combs, Department of Nutrition, University of North Carolina; 919-966-7235,

Unraveling the Silky Spider Web

Web-making spiders employ a host of silk glands to synthesize a variety of silk filaments with different mechanical properties. Although it is widely believed that the aciniform glands are one such silk factory, there has been no hard evidence linking aciniform-derived proteins and silk until now. Craig Vierra and colleagues found that the aciniform gland in the Black Widow manufactures and extrudes a previously unidentified protein that is a component of multiple types of silk.

Vierra and colleagues used mass spectroscopy to analyze the protein content of two types of silk: the variety used for egg cases and the one used to wrap up prey. In both types they uncovered a thin protein fiber with a similar structure to another known silk protein called AcSp1. When they examined the expression of this new protein, termed AcSp1-like protein, in different silk glands, they found that mRNA levels were present at 1000-fold higher concentration in the aciniform gland compared to other glands.

The researchers note this finding is intriguing since it shows that aciniform silk fibers are not made for one specific task but rather get integrated into multiple silk types. They plan to further characterize the mechanics of aciniform silk, but they propose that this thin fiber acts like twine to hold thicker silk fibers together.

ARTICLE: Aciniform spidroin: A constituent of egg case sacs and wrapping silk fibers from the black widow spider, Latrodectus Hesperus by Keshav Vasanthavada, Xiaoyi Hu, Arnold M. Falick, Coby LaMattina, Anne M.F. Moore, Patrick R. Jones, Russell Yee, Ryan Reza, Tiffany Tuton, and Craig A. Vierra

CORRESPONDING AUTHOR: Craig Vierra, Department of Biological Sciences, University of the Pacific; 209-946-3024,


Contact: Nick Zagorski
American Society for Biochemistry and Molecular Biology  

Related biology news :

1. Story ideas from the Journal of Lipid Research
2. Story tips from the US Department of Energys Oak Ridge National Laboratory, September 2007
3. Satellites witness lowest Arctic ice coverage in history
4. Census of protein architectures offers new view of history of life
5. New study sheds light on Galápagos hawk evolutionary history
6. Microfossils disclose geologic history of eastern California
7. Story ideas from Molecular & Cellular Proteomics
8. Story tips from the Department of Energys Oak Ridge National Laboratory, October 2007
9. Dominant cholesterol-metabolism ideas challenged by new research
10. News tips from the Journal of Neuroscience
11. Tips from the Journals of the American Society for Microbiology
Post Your Comments:
Related Image:
Story ideas from the Journal of Biological Chemistry
(Date:11/17/2015)... Paris from 17 th until 19 ... from 17 th until 19 th November 2015. ... invented the first combined scanner in the world which scans ... now two different scanners were required: one for passports and ... the same surface. This innovation is an ideal solution for ...
(Date:11/17/2015)... Calif. , Nov. 17, 2015  Vigilant Solutions ... has joined its Board of Directors. ... Board after recently retiring from the partnership at TPG ... 107 companies with over $140 Billion in revenue.  He ... improvement across all the TPG companies, from 1997 to ...
(Date:11/16/2015)... SAN JOSE, Calif. , Nov 16, 2015 ... leading developer of human interface solutions, today announced ... new Synaptics TouchView ™ touch controller and ... the architectural revolution of smartphones. These new TDDI ... and include TD4100 (HD resolution), TD4302 (WQHD resolution), ...
Breaking Biology News(10 mins):
(Date:11/24/2015)... /PRNewswire/ - Aeterna Zentaris Inc. (NASDAQ:  AEZS) (TSX: AEZ) (the ... the Toronto Stock Exchange, confirms that as of the ... developments that would cause the recent movements in the ... --> About Aeterna Zentaris Inc. ... Aeterna Zentaris is a specialty biopharmaceutical company engaged in ...
(Date:11/24/2015)... ... 2015 , ... The Academy of Model Aeronautics (AMA), led by its Executive ... Multirotor Grand Prix, to represent the First–Person View (FPV) racing community. , FPV racing ... this type of racing and several new model aviation pilots have joined the community ...
(Date:11/24/2015)... , Nov. 24, 2015 /PRNewswire/ - Aeterna Zentaris ... today that the remaining 11,000 post-share consolidation (or ... Warrants (the "Series B Warrants") subject to the ... on November 23, 2015, which will result in ... giving effect to the issuance of such shares, ...
(Date:11/24/2015)... , ... November 24, 2015 , ... ... OrthoAccel® Technologies, Inc., on being named to Deloitte's 2015 Technology Fast 500 list ... facility, OrthoAccel manufactures AcceleDent®, a FDA-cleared, Class II medical device that speeds up ...
Breaking Biology Technology: