Navigation Links
Stopping the worm from turning
Date:6/4/2013

Despite the clear arguments for controlling parasitic infections, we know surprisingly little about the developmental processes in parasitic nematodes. A good model system for research is provided by Oesophagostomum dentatum, a roundworm which infects the large intestines of pigs, slowing the animals' growth and leading to significant economic losses. A number of chemicals are available to help keep the parasite in check but the worms are growing increasingly resistant to their use and so there is a substantial need for new methods of treatment.

From eggs to parasites

The worm, Oesophagostomum dentatum, has a fairly simple life cycle. Eggs appear in the faeces around 3 weeks after ingestion of third-stage larvae, the so called L3 stage larvae. In the first two developmental stages, the larvae are not infective. The third-stage larvae migrate from the faeces into the surroundings, where they can again be ingested by pigs. When the parasite reaches the large intestine, the third-stage larvae burrow into the mucosal layer of the intestinal wall and moult to fourth-stage larvae. After a further 6-17 days they emerge from the mucosa and undergo a final moult before they mature into adults and reproduce.

Drug screen on worm proteins

Together with colleagues in Australia and the USA, Martina Ondrovics in the group of Anja Joachim at the University of Veterinary Medicine, Vienna (Vetmeduni) has undertaken a detailed in vitro investigation of the proteins involved in the transition from third-stage to fourth-stage larvae. The researchers employed an integrative approach that combined in vitro drug testing with proteomic and bioinformatic analysis. Previous work had identified a number of enzymes (hydrolases) that are likely to have a role in parasite development. Ondrovics used sophisticated techniques to examine the effects of certain compounds (enzyme inhibitors) on the larval protein composition.

Searc
'/>"/>

Contact: Martina Ondrovics
martina.ondrovics@vetmeduni.ac.at
43-125-077-2218
University of Veterinary Medicine -- Vienna
Source:Eurekalert

Page: 1 2

Related biology news :

1. Einstein study reveals new approach for stopping herpes infections
2. Stopping smoking reduces risk of bacterial pneumonia in people with HIV
3. Stopping flies before they mature
4. Turning human stem cells into brain cells sheds light on neural development
5. Returning military personnel to duty following severe injury to the lower extremity
6. Researchers find molecular switch turning on self-renewal of liver damage
7. AZTI-Tecnalia is turning vegetable by-products destined for landfills into feedstuff
8. Zebrafish may hold the answer to repairing damaged retinas and returning eyesight to people
9. Why astronauts experience low blood pressure after returning to Earth from space
10. Turning ideas into products faster
11. Turning down the dial: Ocean energy development with less sound
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/22/2014)... -- NXT-ID, Inc. (NASDAQ: NXTD and NXTDW) ... on the growing mobile commerce market, announces it has ... Robbins for the 2015 International CES debut of ... Apollo Robbins will be at the NXT-ID booth ... of his famous theft techniques to visiting media and ...
(Date:12/19/2014)... Research and Markets ( http://www.researchandmarkets.com/research/86ncd6/micro_market ) ... Monitor: North America Perimeter Security Systems Market" report ... The North American perimeter security market ... from 2014 to 2019. Although the U.S. market holds ... is expected to grow at a higher ...
(Date:12/17/2014)... 2014 The Defense Logistics Agency is ... detect and prevent counterfeit microcircuits from entering into ... started performing an in-house microcircuit anti-counterfeit initiative dubbed ... of purchased microcircuits while increasing their reliability throughout ... will be conducted at DLA,s Electronics Product Test ...
Breaking Biology News(10 mins):NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 2NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 3NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 4Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 3Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 2Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 3
... A impairs the function of proteins that are vital ... reported by researchers from the Ruhr-Universitt Bochum and the ... in many plastic products and is suspected of being ... that bisphenol A produces a harmful effect by binding ...
... 2014 /PRNewswire-iReach/ -- Urbanrehab: Physiotherapy and Rehabilitation Specialists, a ... has just announced that they have secured a strategic ... Mark Chern that will allow them to ... . (Photo: http://photos.prnewswire.com/prnh/20140109/MN43520 ) ...
... the speakers for the New & Notable Symposium, which ... in San Francisco, California. The New & Notable ... biophysics. Speakers are nominated by the Society,s membership and ... before the meeting. Over 150 nominations were received this ...
Cached Biology News:Evidence of harmful effect of bisphenol A-based plastics 2Traditional Chinese Medicine in Singapore is Now Available at Urbanrehab Pte Ltd 2Traditional Chinese Medicine in Singapore is Now Available at Urbanrehab Pte Ltd 3Biophysical Society Annual Meeting 2
(Date:12/24/2014)... ST. LOUIS , Dec. 23, 2014 /PRNewswire/ ... announced today that the waiting period under the ... with the acquisition expired on December 22, 2014, ... and review requirement for the acquisition of the ... U.S. antitrust clearance satisfies another condition to ...
(Date:12/22/2014)... 2014 /PRNewswire/ - RepliCel Life Sciences Inc. (OTCQB: REPCF) ... on the development of autologous cell therapies, announced today ... of Calgary in conjunction with co-authors from Kyoto University ... the company,s ongoing clinical research using dermal sheath cup ... The paper entitled " Hair Follicle Dermal ...
(Date:12/22/2014)... Illinois (PRWEB) December 22, 2014 ITRA ... tenants and occupiers of commercial real estate, has further ... new offices in Perth and Brisbane, Western Australia, reports ... of directors. , ITRA Global / ACORPP (Australian ... totally independent consultancy company providing property services to a ...
(Date:12/19/2014)... , Dec. 19, 2014 Naurex Inc., ... novel drugs for diseases of the central nervous system, ... and chief executive officer, will present at the 33 ... presentation will take place at 3:00 p.m. PST on ... in San Francisco, Calif. ...
Breaking Biology Technology:Acquisition of Sigma-Aldrich by Merck KGaA, Darmstadt, Germany, Receives U.S. Antitrust Clearance 2Acquisition of Sigma-Aldrich by Merck KGaA, Darmstadt, Germany, Receives U.S. Antitrust Clearance 3Newly Released Peer-Reviewed Publication Further Validates RepliCel's Use of Dermal Sheath Cup Cells to Treat Pattern Baldness 2Newly Released Peer-Reviewed Publication Further Validates RepliCel's Use of Dermal Sheath Cup Cells to Treat Pattern Baldness 3Newly Released Peer-Reviewed Publication Further Validates RepliCel's Use of Dermal Sheath Cup Cells to Treat Pattern Baldness 4Newly Released Peer-Reviewed Publication Further Validates RepliCel's Use of Dermal Sheath Cup Cells to Treat Pattern Baldness 5ITRA Global Continues International Expansion in Perth and Brisbane, Australia 2Naurex to Present at 33rd Annual J.P. Morgan Healthcare Conference 2
... TARRYTOWN, N.Y., Oct. 15 EpiCept Corporation,(Nasdaq and ... John Drewe,Senior Director of Lead Discovery, will be ... Targets at the Hotel Del Coronado in San ... describe the advances into pre-clinical,testing of drug discovery ...
... Mich., Oct. 15 In only a few days ... Network has,already received dozens of inquiries from around the ... The Michigan Virtual BioPharma Company, LLC and the ... to be launched at an,exhibit at 5:00 p.m. on ...
... Meeting is the premier,meeting in the science and practice ... treatments, and the results from pilot and,multicenter studies. ... liver disease,and the diseases strike disproportionately among certain populations ... treatments,for both hepatitis B and C, whereas liver cancer ...
Cached Biology Technology:EpiCept to Present Pre-clinical Advances of Myc Oncogene Directed Drug Discovery at Assays and Cellular Targets Conference 2EpiCept to Present Pre-clinical Advances of Myc Oncogene Directed Drug Discovery at Assays and Cellular Targets Conference 3EpiCept to Present Pre-clinical Advances of Myc Oncogene Directed Drug Discovery at Assays and Cellular Targets Conference 4EpiCept to Present Pre-clinical Advances of Myc Oncogene Directed Drug Discovery at Assays and Cellular Targets Conference 5Michigan Life Science Network: Virtual Companies Get Global Reception 2
... For use with suspension ... RiboCap™ uses vacuum filtration or ... culture media. Compatible with ... available in larger package sizes ...
nuclear cap binding protein subunit 1, 80kDa, mRNA...
... Captivate magnetic separator for ... used in conjunction with the ... C-21476) or other magnetic particles ... 96-well microplates. Cell Biology Cell ...
ANTI DEOXY CORTICO...
Biology Products: