Navigation Links
Stomach bacteria need vitamin to establish infection
Date:8/19/2010

Scientists have determined that Helicobacter pylori, the bacterium that causes peptic ulcers and some forms of stomach cancer, requires the vitamin B6 to establish and maintain chronic infection, according to research published this week in the online journal mBio. This finding, along with the identification of the enzyme the microbe requires to utilize the vitamin, could lead to the development of an entirely new class of antibiotics.

"Approximately half the world's population is infected with H. pylori, yet how H. pylori bacteria establish chronic infections in human hosts remains elusive. To our knowledge, this study is the first to describe a link between this vitamin and bacterial pathogenesis," says Richard Ferrero of Monash University in Melbourne, Australia, a researcher on the study which also included scientists from the Institut Pasteur and the University of Notre Dame, Sydney, Australia.

To better understand how H. pylori causes disease, Ferrero and his colleagues used a method known as in vitro attenuation to create low-infectivity variants of the bacteria and then compared the gene expression profiles to that of the original highly infectious bacteria. Using this method they identified PdxA and PdxJ, enzymes involved in vitamin B6 biosythesis, as being important factors for the chronic colonization of mice by H. pylori. Bacteria that lacked these enzymes were unable to establish a chronic infection in a mouse model.

"This work identifies vitamin B6 biosynthesis enzymes as novel virulence factors for bacterial pathogens," says Ferrero. "Interestingly, a number of human pathogens, but not their mammalian hosts, possess these genes, which suggests that Pdx enzymes may represent ideal candidates for new therapeutic drugs."


'/>"/>

Contact: James Sliwa
jsliwa@asmusa.org
202-942-9297
American Society for Microbiology
Source:Eurekalert

Page: 1

Related biology news :

1. Stomach ulcer bug causes bad breath
2. Broccoli sprouts may prevent stomach cancer by defeating Helicobacter pylori
3. Glutamine supplements show promise in treating stomach ulcers
4. Fatty foods -- not empty stomach -- fire up hunger hormone
5. Tummy troubles -- gastrin key in bacterial-induced stomach cancer
6. Taking sharper aim at stomach ulcer bacteria
7. Team finds link between stomach-cancer bug and cancer-promoting factor
8. Gene regulation: Can we stomach it?
9. Immune system important in fight against stomach cancer
10. Disinfectants can make bacteria resistant to treatment
11. H. Pylori bacteria may help prevent some esophageal cancers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/7/2016)... June 7, 2016  Syngrafii Inc. and San ... relationship that includes integrating Syngrafii,s patented LongPen™ eSignature ... This collaboration will result in greater convenience for ... union, while maintaining existing document workflow and compliance ... ...
(Date:6/2/2016)...   The Weather Company , an IBM Business (NYSE: ... capability in which consumers will be able to interact with ... via voice or text and receive relevant information about the ... Marketers have long sought an advertising solution that can create ... relevant and valuable; and can scale across millions of interactions ...
(Date:5/24/2016)... facilitates superior patient care by providing unparalleled technology to leaders of the medical imaging ... product recently added to the range of products distributed by Ampronix. Photo ... ... ... News ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... 2016   EpiBiome , a precision microbiome engineering ... debt financing from Silicon Valley Bank (SVB). The financing ... advance its drug development efforts, as well as purchase ... "SVB has been an incredible strategic partner to us ... bank would provide," said Dr. Aeron Tynes Hammack ...
(Date:6/23/2016)... ON (PRWEB) , ... June 23, 2016 , ... STACS ... DNA Technical Leader at the Arkansas State Crime Laboratory, has joined STACS DNA as ... the STACS DNA team,” said Jocelyn Tremblay, President and COO of STACS DNA. “In ...
(Date:6/23/2016)... LOUISVILLE, Ky. , June 23, 2016 /PRNewswire/ ... from two Phase 1 clinical trials of its ... double-blind, placebo-controlled, single and multiple ascending dose studies ... and pharmacodynamics (PD) of subcutaneous injection in healthy ... APL-2 subcutaneously (SC) either as a single dose ...
(Date:6/23/2016)... , June 23, 2016 ... Hematology Review, 2016;12(1):22-8 http://doi.org/10.17925/OHR.2016.12.01.22 ... , the peer-reviewed journal from touchONCOLOGY, Andrew ... escalating cost of cancer care is placing an ... result of expensive biologic therapies. With the patents ...
Breaking Biology Technology: