Navigation Links
Stomach bacteria need vitamin to establish infection
Date:8/19/2010

Scientists have determined that Helicobacter pylori, the bacterium that causes peptic ulcers and some forms of stomach cancer, requires the vitamin B6 to establish and maintain chronic infection, according to research published this week in the online journal mBio. This finding, along with the identification of the enzyme the microbe requires to utilize the vitamin, could lead to the development of an entirely new class of antibiotics.

"Approximately half the world's population is infected with H. pylori, yet how H. pylori bacteria establish chronic infections in human hosts remains elusive. To our knowledge, this study is the first to describe a link between this vitamin and bacterial pathogenesis," says Richard Ferrero of Monash University in Melbourne, Australia, a researcher on the study which also included scientists from the Institut Pasteur and the University of Notre Dame, Sydney, Australia.

To better understand how H. pylori causes disease, Ferrero and his colleagues used a method known as in vitro attenuation to create low-infectivity variants of the bacteria and then compared the gene expression profiles to that of the original highly infectious bacteria. Using this method they identified PdxA and PdxJ, enzymes involved in vitamin B6 biosythesis, as being important factors for the chronic colonization of mice by H. pylori. Bacteria that lacked these enzymes were unable to establish a chronic infection in a mouse model.

"This work identifies vitamin B6 biosynthesis enzymes as novel virulence factors for bacterial pathogens," says Ferrero. "Interestingly, a number of human pathogens, but not their mammalian hosts, possess these genes, which suggests that Pdx enzymes may represent ideal candidates for new therapeutic drugs."


'/>"/>

Contact: James Sliwa
jsliwa@asmusa.org
202-942-9297
American Society for Microbiology
Source:Eurekalert

Page: 1

Related biology news :

1. Stomach ulcer bug causes bad breath
2. Broccoli sprouts may prevent stomach cancer by defeating Helicobacter pylori
3. Glutamine supplements show promise in treating stomach ulcers
4. Fatty foods -- not empty stomach -- fire up hunger hormone
5. Tummy troubles -- gastrin key in bacterial-induced stomach cancer
6. Taking sharper aim at stomach ulcer bacteria
7. Team finds link between stomach-cancer bug and cancer-promoting factor
8. Gene regulation: Can we stomach it?
9. Immune system important in fight against stomach cancer
10. Disinfectants can make bacteria resistant to treatment
11. H. Pylori bacteria may help prevent some esophageal cancers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2016)... April 28, 2016 First quarter 2016:   ... 966% compared with the first quarter of 2015 The ... 589.1 M (loss: 18.8) and the operating margin was 40% (-13) ... Cash flow from operations was SEK 249.9 M (21.2) ... guidance is unchanged, SEK 7,000-8,500 M. The operating margin ...
(Date:4/26/2016)... , April 27, 2016 ... the  "Global Multi-modal Biometrics Market 2016-2020"  report to ... ) , The analysts forecast the ... CAGR of 15.49% during the period 2016-2020.  ... number of sectors such as the healthcare, BFSI, ...
(Date:4/15/2016)... 15, 2016  A new partnership announced today ... underwriting decisions in a fraction of the time ... and high-value life insurance policies to consumers without ... With Force Diagnostics, rapid testing (A1C, Cotinine and ... (blood pressure, weight, pulse, BMI, and activity data) ...
Breaking Biology News(10 mins):
(Date:5/3/2016)... ... May 03, 2016 , ... In a list published by the Boston ... 76 fastest-growing private companies; a small percentage of the state's 615,000+ small businesses. The ... percent change in revenue from 2012 to 2015. , As this award ...
(Date:5/3/2016)... , May 3, 2016 ... Assessing Developers and Producers of Those Competitor Biologics  ... to Companies, Activities and Prospects ,  Who ... companies? And what are their sales potentials? Discover, ... you see results, trends, opportunities and revenue forecasting. ...
(Date:5/2/2016)... Willoughby, Ohio (PRWEB) , ... May 02, 2016 ... ... website. Designed with its clients in mind, the fresh look and added functionality ... capabilities. , “Recent years have seen a dynamic shift in agriculture – from ...
(Date:4/29/2016)... ... April 29, 2016 , ... Amendia, Inc., a ... procedures, today announced the completion of a significant transaction and partnership that positions ... customers and partners. Kohlberg & Company, L.L.C. (“Kohlberg”), a leading private equity ...
Breaking Biology Technology: