Navigation Links
Stomach bacteria need vitamin to establish infection
Date:8/19/2010

Scientists have determined that Helicobacter pylori, the bacterium that causes peptic ulcers and some forms of stomach cancer, requires the vitamin B6 to establish and maintain chronic infection, according to research published this week in the online journal mBio. This finding, along with the identification of the enzyme the microbe requires to utilize the vitamin, could lead to the development of an entirely new class of antibiotics.

"Approximately half the world's population is infected with H. pylori, yet how H. pylori bacteria establish chronic infections in human hosts remains elusive. To our knowledge, this study is the first to describe a link between this vitamin and bacterial pathogenesis," says Richard Ferrero of Monash University in Melbourne, Australia, a researcher on the study which also included scientists from the Institut Pasteur and the University of Notre Dame, Sydney, Australia.

To better understand how H. pylori causes disease, Ferrero and his colleagues used a method known as in vitro attenuation to create low-infectivity variants of the bacteria and then compared the gene expression profiles to that of the original highly infectious bacteria. Using this method they identified PdxA and PdxJ, enzymes involved in vitamin B6 biosythesis, as being important factors for the chronic colonization of mice by H. pylori. Bacteria that lacked these enzymes were unable to establish a chronic infection in a mouse model.

"This work identifies vitamin B6 biosynthesis enzymes as novel virulence factors for bacterial pathogens," says Ferrero. "Interestingly, a number of human pathogens, but not their mammalian hosts, possess these genes, which suggests that Pdx enzymes may represent ideal candidates for new therapeutic drugs."


'/>"/>

Contact: James Sliwa
jsliwa@asmusa.org
202-942-9297
American Society for Microbiology
Source:Eurekalert

Page: 1

Related biology news :

1. Stomach ulcer bug causes bad breath
2. Broccoli sprouts may prevent stomach cancer by defeating Helicobacter pylori
3. Glutamine supplements show promise in treating stomach ulcers
4. Fatty foods -- not empty stomach -- fire up hunger hormone
5. Tummy troubles -- gastrin key in bacterial-induced stomach cancer
6. Taking sharper aim at stomach ulcer bacteria
7. Team finds link between stomach-cancer bug and cancer-promoting factor
8. Gene regulation: Can we stomach it?
9. Immune system important in fight against stomach cancer
10. Disinfectants can make bacteria resistant to treatment
11. H. Pylori bacteria may help prevent some esophageal cancers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/20/2017)... , July 20, 2017 Delta (NYSE: DAL ) ... any Delta aircraft at Reagan Washington National Airport (DCA). ... Delta launches biometrics to board ... Delta,s biometric boarding ... Club is now integrated into the boarding process to allow eligible ...
(Date:6/14/2017)...  IBM (NYSE: IBM ) is introducing several innovative ... to developing collaboration between startups and global businesses, taking place ... the event, nine startups will showcase the solutions they have ... France is one ... a 30 percent increase in the number of startups created ...
(Date:5/16/2017)... DALLAS , May 16, 2017   ... for health organizations, and MD EMR Systems ... certified development partner for GE, have established a ... Patient Portal product and the GE Centricity™ products, ... Centricity EMR. These new integrations ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... , ... October 11, 2017 , ... ... the implantation and pregnancy rates in frozen and fresh in vitro fertilization ... progesterone and maternal age to IVF success. , After comparing the results from ...
(Date:10/10/2017)... ... , ... Dr. Bob Harman, founder and CEO of VetStem Biopharma, Inc. ... The event entitled “Stem Cells and Their Regenerative Powers,” was held on August ... MPVM was joined by two human doctors: Peter B. Hanson, M.D., Chief of Orthopedic ...
(Date:10/9/2017)... , Oct. 9, 2017  BioTech Holdings announced ... by which its ProCell stem cell therapy prevents ... ischemia.  The Company, demonstrated that treatment with ProCell ... limbs saved as compared to standard bone marrow ... HGF resulted in reduction of therapeutic effect.  ...
(Date:10/7/2017)... ... October 06, 2017 , ... ... and applications consulting for microscopy and surface analysis, Nanoscience Instruments is now ... Analytical offers a broad range of contract analysis services for advanced applications. ...
Breaking Biology Technology: