Navigation Links
Stimulus grant to fund whole-genome sequencing in children with autism
Date:9/30/2009

hnology and informatics techniques that should help to understand many kids with autism," Walsh says.

The team will begin by analyzing the "exome" the 2 percent of the genome that directly codes for proteins. For patients whose genetic cause remains a mystery, a second phase of the study will sequence and analyze the entire genome's 3.2 billion base pairs (combinations of A, C, T and G) that make up our full complement of 20,000 to 25,000 genes. In this way, the researchers hope to discover noncoding portions of the genome -- sometimes called "junk" DNA -- that don't make proteins but may contain critical switches that control gene activity.

The informatics part of the project, led by Timothy Yu, MD, PhD, in the Walsh Lab, will be the most important and challenging. With new machines, DNA sequencing has become relatively easy and cheap; what's hard is interpreting the flood of information. The researchers will compare sequence information from their autism patients with that from normal controls, using data from the international "1000 Genomes Project," allowing them to distinguish normal person-to-person genetic variations from variations that cause autism. "These new data should give us enormous power to interpret the findings in our autism patients, and figure out what's the signal and what's noise," Walsh says. "Three million letters in the DNA sequence may differ between you and me -- we need to figure out which changes are causing the disease."

A separate part of the project, led by Greenberg, will look at gene activity in human neurons, focusing on genes that lie in chunks of DNA that were previously found to be deleted in the Middle Eastern families with autism. In 2008, Greenberg and Walsh reported that some autism mutations may affect "promoter" or "enhancer" sequences, bits of DNA that act as "on/off" switches controlling gene activity. (See: http://www.childrenshospital.org/newsroom/Site1339/mainpageS1339P1sublevel445.html.)
'/>"/>

Contact: Jamie Newton
james.newton@childrens.harvard.edu
617-919-3110
Children's Hospital Boston
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Stimulus-funded university research addressing issues from climate change to cancer, creating jobs and training a new generation of scientists
2. Stimulus funding helps K-State bring undergrads to prairie for ecology, molecular biology research
3. Stimulus funding helps K-State biochemist study eyes lens in diabetes, galactosemia patients
4. NIH stimulus funding supports Emory biomedical scientists
5. University of Miami receives stimulus funds for study of hurricane impacts on structures, ecosystems
6. MSU researchers receive $400,000 in first wave of stimulus funding
7. Bulls-eye electrode helps interpret thoughts, deliver stimulus to aid paralyzed, epileptic patients
8. MCG researcher among first to receive NIH stimulus funding
9. Tigers get a stimulus plan
10. Delaware State U. receives $5 million NASA grant for optics research
11. PyroHands: NC State receives grant to develop next generation firefighter gloves
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2015)... China , 31 de julio de 2015 /PRNewswire/ ... Genómica (ICG-10,  www.icg-10.org ) del 22 al 25 de ... . La conferencia celebra su décimo aniversario ... ha convertido en una de las reuniones anuales más ... y es una de las conferencias científicas más dinámicas, ...
(Date:7/31/2015)... OXFORD, Conn. , Jul. 31, 2015 NXT-ID, ... a biometric authentication company focused on the growing mobile ... announces that it has filed provisional patent 62/198989 for ... This invention highlights a method to advance crypto-currencies ... technology by introducing a common, uniform way to manage ...
(Date:7/23/2015)... Aware, Inc. (NASDAQ: AWRE ), a leading supplier of ... second quarter ended June 30, 2015.  Revenue ... decrease of 33% compared to $6.8 million in the same ... 2015 was $0.3 million, or $0.01 per diluted share, which ... the same period a year ago.  Lower ...
Breaking Biology News(10 mins):La 10ª Conferencia Internacional sobre Genómica (ICG-10) comienza en octubre 2La 10ª Conferencia Internacional sobre Genómica (ICG-10) comienza en octubre 3NXT-ID Patents Electronic Crypto-Currency Management Technology 2NXT-ID Patents Electronic Crypto-Currency Management Technology 3NXT-ID Patents Electronic Crypto-Currency Management Technology 4Aware, Inc. Reports Second Quarter 2015 Financial Results 2Aware, Inc. Reports Second Quarter 2015 Financial Results 3Aware, Inc. Reports Second Quarter 2015 Financial Results 4Aware, Inc. Reports Second Quarter 2015 Financial Results 5Aware, Inc. Reports Second Quarter 2015 Financial Results 6
... of thousands of albatrosses and other far-ranging seabirds are killed ... Innovative new models developed by a Duke University-led research team ... where and when birds and boats are likely to cross ... data to predict changing conditions such as sea surface ...
... of ancient enzymes adapted to substantial changes in ocean ... providing evidence that life on Early Earth evolved from ... less acidic global environment that exists today. The ... as thioredoxin were chemically stable at temperatures up to ...
... Researchers at the University of Massachusetts Medical School ... protein IFT88 in mitosis, the process by which a ... into two identical sets of new daughter cells. Published ... this newly discovered function for IFT88 suggests a possible ...
Cached Biology News:New models may reduce seabird bycatch 2Protein adaptation shows that life on early earth lived in a hot, acidic environment 2Protein adaptation shows that life on early earth lived in a hot, acidic environment 3Protein adaptation shows that life on early earth lived in a hot, acidic environment 4Researchers identify new role for cilia protein in mitosis 2
(Date:7/30/2015)... ATLANTA , July 30, 2015 ... leaders to the 2015 AACC Annual Meeting & ... from July 26–30. The meeting showcased revolutionary ... improves the ability of healthcare providers to diagnose ... get effective medical treatment. As ...
(Date:7/30/2015)... ... July 30, 2015 , ... ... Francois Vieillard as Sales & Marketing Director. , With more than 25 ... be responsible for reinforcing Tronics’ business development activities worldwide. He brings to the ...
(Date:7/30/2015)... VANCOUVER, Washington , July 30, 2015 ... "Biosimulation Market, by Product (Software, Molecular Modeling, PB/PK, PKPD, ... (Drug Discovery & Development, Preclinical, Clinical Trial), by End ... the Biosimulation Market is expected to reach USD 2,107.99 ... at a CAGR of 15.29%. Browse ...
(Date:7/30/2015)... KANSAS CITY, Kan. , July 30, 2015 ... PETX ), a pet therapeutics company focused on ... products for companion animals, today announced that its ... results from a dose confirmation study of AT-016, ... to Aratana for the treatment of osteoarthritis pain ...
Breaking Biology Technology:Innovative Research on Cancer, Heart Disease, and Infectious Diseases Draws More than 17,500 Attendees to 2015 AACC Annual Meeting 2Innovative Research on Cancer, Heart Disease, and Infectious Diseases Draws More than 17,500 Attendees to 2015 AACC Annual Meeting 3Innovative Research on Cancer, Heart Disease, and Infectious Diseases Draws More than 17,500 Attendees to 2015 AACC Annual Meeting 4Tronics appoints Francois Vieillard as Sales and Marketing Director 2Biosimulation Market Worth 2,107.99 Million USD by 2020 2Biosimulation Market Worth 2,107.99 Million USD by 2020 3Biosimulation Market Worth 2,107.99 Million USD by 2020 4Aratana Therapeutics Announces Positive Pilot Field Study for AT-016 2Aratana Therapeutics Announces Positive Pilot Field Study for AT-016 3Aratana Therapeutics Announces Positive Pilot Field Study for AT-016 4Aratana Therapeutics Announces Positive Pilot Field Study for AT-016 5
... - In the aftermath of a critical state ... development work being done by the state's Certified Capital Companies. ... Investors Management, LLC , said the findings of the ... picture of the work being done by the so-called CAPCOs, ...
... Allis, Wis. - Merge Technologies Inc. , ... under the name Merge Healthcare, said it has received a ... warning that the company remains subject to delisting after ... failure to timely file its report for the quarter ended ...
... generation of high-performance wireless communication devices could rely on ... of Wisconsin-Madison . , ,But these are no ordinary ... technology 14 years in the making, are examining a ... the tiny electromechanical systems into which it could be ...
Cached Biology Technology:Venture capitalist defends Wisconsin CAPCOs 2Venture capitalist defends Wisconsin CAPCOs 3Nano-diamond film studied at UW could advance telecommunications 2Nano-diamond film studied at UW could advance telecommunications 3
Improve inventory management with stainless steel red cell canisters; ensure product safety with CO2 or LN2 backup systems. A complete solution for your blood banking needs....
... 135 S steam sterilizers with their ultra-flat steam ... of a double-walled device - low energy consumption, ... by built-in jacket heater - with those of ... is free of furnishings and feed water and ...
... SuperScript™ II RNase H- Reverse Transcriptase (RT) ... RNase H- RT. It is a DNA ... from single-stranded RNA DNA or an RNA:DNA ... the introduction of point mutations rather than ...
Request Info...
Biology Products: