"To understand how this enzyme works, my lab has previously used a technique called X-ray crystallography to essentially take before and after snapshots of the cytochrome P450 enzyme that is, still shots before and after foreign chemicals like nicotine bind to it," said Scott. "This grant will support application of a new technique, nuclear magnetic resonance, which will essentially allow us to obtain a video of the cytochrome P450 as it binds different chemicals. It's like the difference between looking at before and after pictures of a car crash and watching a video of that car crash when trying to figure out what happened." Learn more
Getting to the Roots of Pain in the Brain
Last year, Sean Mackey an associate professor of anesthesia and pain management at the Stanford University School of Medicine, applied for a grant to continue studying the roots of pain in the brain, but funding was unavailable. Now, with the benefit of stimulus funding from the National Institutes of Health, he will be able to expand his work. Mackey is using functional magnetic resonance imaging (fMRI) to control brain activities in real time. According to Mackey, the research not only will help in pain management but may also shed light on addiction, cognitive development, depression and brain injury. Further, the funds will enable him to hire two full-time employees, in addition to providing faculty salary support for him and his collaborators in radiology, psychiatry and psychology.
"It's a wonderful opportunity," Mackey said. "We expect the resources from this grant will ultimately benefit a number of groups beyond our lab. There's much interest in real-time fMRI across the campus." Learn more
Developing Cancer-Fighting Drugs
West Virginia University Chemistry Professor George O'Doherty and his team of
|Contact: Ashley Prime|
The Science Coalition