Navigation Links
Sticky protein helps reinforce fragile muscle membranes
Date:7/23/2009

king with a mouse model of these diseases, the researchers, including Renzhi Han, Ph.D., a UI research scientist and the first author of the study, found that injecting functional dystroglycan into muscle that lacks this component restored muscle membrane integrity and protected the muscles from damage.

"Injecting the protein helped us prove that glycosylated dystroglycan is required to attach the membrane to the extracellular proteins and thus reinforce the membrane integrity," said Campbell, who also holds the Roy J. Carver Chair of Physiology and Biophysics. "However, this tool also suggests that delivering functional dystroglycan to muscles may be a possible therapeutic approach for treating these muscular dystrophies."

Another experiment, which also confirmed the role of glycosylated dystroglycan in binding the membrane and the basal lamina, also may have clinical implications.

The team showed that a virus called LCMV (Lymphocytic Choriomeningitis virus), which binds tightly to alpha dystroglycan, also disrupts the basal lamina muscle membrane interaction and compromises the integrity of the muscle membranes. LCMV is a member of a group of viruses that can cause hemorrhagic diseases. The study suggests that these viruses disrupt the dystroglycan basal lamina interaction, rendering the cell membrane susceptible to rupture.

"Considering how essential cell membranes are for life, these barriers are remarkably fragile. In addition, many tissues, including muscle, GI tract and skin, are constantly under mechanical stress, which can rupture cell membranes," Campbell said. "Our findings support the idea that reinforcement of the membrane basal lamina attachment is a basic cellular mechanism that allows cell survival in tissues subjected to mechanical stress."


'/>"/>

Contact: Jennifer Brown
jennifer-l-brown@uiowa.edu
319-356-7124
University of Iowa
Source:Eurekalert  

Page: 1 2

Related biology news :

1. A sticky business -- how cancer cells become more gloopy as they die
2. As sticky as a gecko... but 10 times stronger!
3. Sticky questions tackled in gecko research
4. Plant protein doorkeepers block invading microbes, study finds
5. Protein can help cells or cause cancer, Purdue researcher finds
6. Plant protein doorkeepers block invading microbes, study finds
7. Structural biology scores with protein snapshot
8. Proteins in gel
9. Targeting helpers of heat shock proteins could help treat cancer, cardiovascular disease
10. Researchers observe single protein dimers wavering between two symmetrically opposed structures
11. Cancer-causing protein can also help fight the tumors it causes
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Sticky protein helps reinforce fragile muscle membranes
(Date:4/21/2015)... BURNABY, Canada , April 21, 2015 ... spending and evolving government policies are boosting access control ...   According to a recently published report ... & Opportunities, 2020 ", the access control systems market ... to nearly USD1.2 billion by 2020.The access control systems ...
(Date:4/17/2015)... Increasing adoption in ... to drive biometric systems market in ... According to a recently released TechSci Research ... biometric systems market in Saudi Arabia ... CAGR of over 22% through 2020. The market ...
(Date:4/13/2015)... , April 13, 2015 ... Research, "Global Biometrics Market Forecast & Opportunities, 2020", the ... CAGR of around 14% till 2020. The biometrics ... large scale implementation and review of biometric management ... of new products with greater efficiency, are resulting ...
Breaking Biology News(10 mins):Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 2Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 3Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 2Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 3Global Biometrics Market to Cross US$ 21 Billion by 2020: TechSci Research 2
... diabetes study at the University of Leicester has discovered that ... origin) have higher levels of blood sugar than white Europeans ... The study of 4,688 white Europeans and 1,352 South Asians ... of Leicester, Department of Cardiovascular Sciences, and was published in ...
... of human beings, clusters of living cells are ... analytic techniques however evaluate cells in tissue aggregates, ... clues concerning health and disease. ASU ... colleagues at Arizona State University,s Biodesign Institute are ...
... which could lead to a new generation of ... initiative that brings together scientific expertise from China and ... University of Edinburgh and BGI, the world,s largest genomics ... in genomics. It will aim to enhance researchers, ...
Cached Biology News:Breakthrough technology focuses in on disease traits of single cells 2Breakthrough technology focuses in on disease traits of single cells 3Breakthrough technology focuses in on disease traits of single cells 4Scots link-up with China to boost genetic research 2
(Date:5/21/2015)... 20, 2015 Research and Markets ... the "2015 Global Survey on Flow Cytometry ... The primary goal of this research is ... and reagents. Key information the survey seeks to ... flow cytometers, predominantly used applications for flow cytometers, ...
(Date:5/21/2015)... (PRWEB) May 21, 2015 Tunnell ... joined the firm as senior statistician and Principal, a ... of experience in the management and analysis of complex ... and chemical industries. , “We’re delighted to have Julia ... in data analytics,” said Dr. Philippe Cini, Group Vice ...
(Date:5/20/2015)... MA (PRWEB) May 20, 2015 This ... history, especially for lawns. US Patented Pearl’s Premium ... for lawns around the country that are coming out ... that addresses a number of major global concerns related ... the “non-grass” grass – the alternative to the standard, ...
(Date:5/20/2015)... The global genotyping market is expected ... forecast period of 2015 to 2020 to reach $17.0billion ... drug discovery and development process and to provide personalized ... to this,heavy investments by key manufacturers to offer advanced ... market growth. Browse 113 market data tables & 37 ...
Breaking Biology Technology:Global Survey on Flow Cytometry Adoption Trends 2015 2Julia O’Neill Joins Tunnell Consulting’s Operational and Process Improvement Practice 2Breakthrough 4th Generation Low Maintenance Lawn Seed Offers Solution to California Drought 2Genotyping Market Growing at 22.3% CAGR to 2020: Research Based on Technology, Applications, Opportunities, Challenges and Key Players. 2Genotyping Market Growing at 22.3% CAGR to 2020: Research Based on Technology, Applications, Opportunities, Challenges and Key Players. 3Genotyping Market Growing at 22.3% CAGR to 2020: Research Based on Technology, Applications, Opportunities, Challenges and Key Players. 4Genotyping Market Growing at 22.3% CAGR to 2020: Research Based on Technology, Applications, Opportunities, Challenges and Key Players. 5
... Artery Disease ... Patients in Real-World Setting, ABBOTT PARK, Ill., July 9 ... with six,hospital centers already recruiting and enrolling patients just one week,after ... Coronary Stent System. The XIENCE V USA study will,evaluate the safety ...
... most promising drugs ... TSX Exchange Symbol: RVX, ... "Company") (TSX:RVX) novel lead ApoA-I drug,candidate, RVX-208 has been selected ... drugs available for strategic partnering by an,independent committee assembled by ...
... an,acute care specialty pharmaceutical company, today announced the,appointment of ... key senior,executive to the company,s management team. Gary Pace, ... executive with more than,30 years of experience. Dr. Pace ... founder and past Chairman and CEO of QRx Pharma,Ltd ...
Cached Biology Technology:Abbott Begins Post-Approval Study of XIENCE V(TM) Drug Eluting Stent 2Abbott Begins Post-Approval Study of XIENCE V(TM) Drug Eluting Stent 3Abbott Begins Post-Approval Study of XIENCE V(TM) Drug Eluting Stent 4Industry Leaders Select Resverlogix's RVX-208 2Industry Leaders Select Resverlogix's RVX-208 3Pacira Pharmaceuticals, Inc. Adds Board Member and Key Senior Management 2
... system consists of AmnioMAX-C100 ... 17001-082) and AmnioMAX-C100 Supplement ... is complete with antibiotics ... and requires no further ...
Immunogen: Recombinant full length protein, corresponding to amino acids 1-435 of Human AP2M1. Storage: -20 C, Avoid Freeze/Thaw Cycles...
... to Parathyroid Hormone Receptor 2 ( ... Antigen: Synthetic ... acids 99-116 of Human Parathyroid Hormone ... Gene ID: 5746 ...
BKBeta2 potassium channel Antigen: Fusion protein amino acids 1-41 (N-terminus) and 218-235 (C-terminus) of mouse BKBeta2 Accession Number: Q9CZM9...
Biology Products: