Navigation Links
Sticky protein helps reinforce fragile muscle membranes
Date:7/23/2009

A new study by scientists at the University of Iowa shows why muscle membranes don't rupture when healthy people exercise.

The findings shed light on a mechanism that appears to protect cells from mechanical stress. The study, which appears online July 20-24 in Proceedings of the National Academy of Sciences (PNAS) Early Edition, also helps explain why muscle damage is so severe when this mechanism is disrupted, which occurs in certain congenital and limb-girdle muscular dystrophies.

Specifically, the team identified a protein called alpha dystroglycan as the "glue" that binds muscle membranes to a tough layer of extracellular proteins called the basal lamina.

Just as a piece of sticky tape can prevent a pin from bursting a balloon, the sturdy basal lamina reinforces muscle cell membranes and keeps small tears from bursting open -- but only if the dystroglycan "glue" affixing the basal lamina to the membrane is working.

"This study helps us understand how membrane structure is designed to protect cells, which is a universally important process," said senior study author Kevin Campbell, Ph.D., professor and head of molecular physiology and biophysics at the UI Roy J. and Lucille A. Carver College of Medicine and a Howard Hughes Medical Institute investigator. "The findings may also have clinical implications for muscular dystrophies that are caused by abnormal dystroglycan."

These congenital muscular dystrophies include Fukuyama Congenital Muscular Dystrophy, Walker-Warburg Syndrome and Muscle-Eye-Brain disease and limb-girdle muscular dystrophy 2I. In these so-called dystroglycanopathies, too few sugar groups are added to alpha dystroglycan, leading to a version of the protein that does not attach properly to the basal lamina. Detachment of the basal lamina from the muscle membrane appears to be a common feature of these conditions, and patients develop a very severe muscular dystrophy.

Wor
'/>"/>

Contact: Jennifer Brown
jennifer-l-brown@uiowa.edu
319-356-7124
University of Iowa
Source:Eurekalert  

Page: 1 2

Related biology news :

1. A sticky business -- how cancer cells become more gloopy as they die
2. As sticky as a gecko... but 10 times stronger!
3. Sticky questions tackled in gecko research
4. Plant protein doorkeepers block invading microbes, study finds
5. Protein can help cells or cause cancer, Purdue researcher finds
6. Plant protein doorkeepers block invading microbes, study finds
7. Structural biology scores with protein snapshot
8. Proteins in gel
9. Targeting helpers of heat shock proteins could help treat cancer, cardiovascular disease
10. Researchers observe single protein dimers wavering between two symmetrically opposed structures
11. Cancer-causing protein can also help fight the tumors it causes
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Sticky protein helps reinforce fragile muscle membranes
(Date:4/23/2014)... leading a 2 million Food Standards Agency (FSA) project ... and industry workers. , Norovirus outbreaks can rapidly ... batch of frozen strawberries infected 11,000 people in Germany, ... of which strains cause infection and which foods are ... , Researchers will produce data that will help the ...
(Date:4/22/2014)... of Montana,s Wildlife Biology Program, co-wrote a research paper published ... of Sciences on how streamwater chemistry varies across a ... Lowe and co-authors from ... the Cary Institute of Ecosystem Studies, the University of Connecticut ... water samples collected every 10 meters along 32 tributaries of ...
(Date:4/22/2014)... of Massachusetts Amherst and the Instituto Nacional de Pesquisas ... have discovered a new genus and species of electric ... the Amazonia State of Brazil. , Professor Cristina Cox ... Antnio Alves-Gomes of INPA, describe the new bluntnose knifefish ... of the Natural Sciences of Philadelphia . , ...
Breaking Biology News(10 mins):New research focuses on streamwater chemistry, landscape variation 2New electric fish genus and species discovered in Brazil's Rio Negro 2
... University College of Medicine, Hershey, Pennsylvania have discovered that ... receptor (OGFr), which mediates the inhibitory action of opioid ... to understanding the progression and treatment of human ovarian ... were molecularly engineered to have a reduced expression of ...
... An assistant professor at Sam Houston State University, ... the mysteries surrounding the role that genetics and ... "Biosocial research is a multi-disciplinary way of ... involves aspects of behavioral genetics, neuroscience, evolutionary biology ...
... richly illustrated book recounts the passionate personalities and the ... the oldest natural history museum in the Western Hemisphere. ... Sciences of Philadelphia and the Making of American Science ... was founded in Philadelphia in 1812. Early expeditions organized ...
Cached Biology News:A breakthrough in understanding the biology and treatment of ovarian cancer 2A breakthrough in understanding the biology and treatment of ovarian cancer 3Are there biosocial origins for antisocial behavior? 2New book brings to life the making of American science at the Academy of Natural Sciences 2
(Date:1/15/2014)... IL (PRWEB) January 15, 2014 Look ... find hard-working items for the lab, from fluid handling ... Guaranteed-in-Stock (GIS)—ready to ship when you order. , ... Peristaltic Pumps , from the L/S® model for precise ...
(Date:1/15/2014)... England , January 15, 2014 A ... win races on the Formula 1 track could help to ... McLaren Applied Technologies (MAT), Stowhealth (a GP surgery based in ... by healthcare provider Simplyhealth. Telemetry technology, which is ...
(Date:1/15/2014)... 2014 2013 was a banner year ... Technologies®. They saw continued independent research led by the ... awarded a $1 million grant from the Susanne Marcus ... Behavior” a peer reviewed journal, Amy Grant highlighted Brainwave ...
(Date:1/14/2014)... Carahsoft and CDS Federal Services have scheduled ... 2pm EST (11am PST), “Natural Language Processing: Converting Raw ... technology can turn raw, heterogeneous data into actionable knowledge ... online webinar will last approximately one hour. , Synopsis: ...
Breaking Biology Technology:Cole-Parmer Begins 2014 with the Release of Preferred Solutions 2Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 2Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 4Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 2Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 3Webcast - Natural Language Processing: Converting Raw Data into Actionable Knowledge – Hosted by Carahsoft and CDS Federal Services 2
... Produces Isobutene From... -- EVRY, France, October 6, 2010 ... ... ... first_result; // Results are keyed by longUrl, so we need to grab the first one. for (var ...
... 6, 2010 ... ... var shortURL = ... so we need to grab the first one. for (var r in data.results) { first_result = data.results[r]; ...
... Knowing how to build nanosized assemblies of polymers (long ... range of industrial processes, from the production of nanofibers, ... nanoscale circuits and devices. A recent paper in ... polymers in specially engineered confined spaces, opening the door ...
Cached Biology Technology:Global Bioenergies Succeeds in Creating a Bacterial Prototype That Produces Isobutene From Glucose 2Global Bioenergies Succeeds in Creating a Bacterial Prototype That Produces Isobutene From Glucose 3Global Bioenergies Succeeds in Creating a Bacterial Prototype That Produces Isobutene From Glucose 4Global Bioenergies Succeeds in Creating a Bacterial Prototype That Produces Isobutene From Glucose 5Global Bioenergies Succeeds in Creating a Bacterial Prototype That Produces Isobutene From Glucose 6Global Bioenergies Succeeds in Creating a Bacterial Prototype That Produces Isobutene From Glucose 7Elsevier Introduces Article-Based Publishing to Increase Publication Speed 2Elsevier Introduces Article-Based Publishing to Increase Publication Speed 3Elsevier Introduces Article-Based Publishing to Increase Publication Speed 4Elsevier Introduces Article-Based Publishing to Increase Publication Speed 5Elsevier Introduces Article-Based Publishing to Increase Publication Speed 6Elsevier Introduces Article-Based Publishing to Increase Publication Speed 7Elsevier Introduces Article-Based Publishing to Increase Publication Speed 8Building a smaller, lighter future: Understanding polymer behaviors below 1 nanometer 2
Human peripheral blood basophils, For immunohistochemistry (IHC) Cell Chip with Human Peripheral Blood Granulocytes...
Umbilical cord blood CD19+ B cells, For immunohistochemistry (IHC) Cell Chip with Human Umbilical Cord Blood Monocytes, B Cells and NK Cells...
Human peripheral blood neutrophils, For immunohistochemistry (IHC) Cell Chip with Human Peripheral Blood Granulocytes...
... has been developed specifically for the ... on microwell plates/strips. Coating Stabilizer ... the antibody or protein antigen portion ... Product is filtered at 0.2 microns., ...
Biology Products: