Navigation Links
Steps toward Stopping Autoimmune Disease
Date:1/20/2008

NEW YORK, January 20, 2008A landmark genetic study has identified multiple genes linked to systemic lupus erythematosus (SLE), or lupus, a debilitating autoimmune disease that affects an estimated 1.4 million Americans.

Lupus can affect the joints, kidneys, heart, lungs, brain and blood and occurs in about 31 out of every 100,000 people. Women are nine times more likely than men to develop the condition, which is often difficult to diagnose.

In 2005 the Alliance for Lupus Research (ALR) formed and supported the International Systemic Lupus Erythematosus Genetics (SLEGEN) Consortium, charging scientists with searching for genetic variants that might predispose an individual to developing lupus.

Published in the January 20, 2008, issue of Nature Genetics, initial study results uncovered several genes linked to lupus and underscore the importance of genetic variants in diseases that affect immune function. The findings will ultimately lead to new therapies and earlier diagnosis.

The SLEGEN study is a model for collaborative genetic research, said Mary Kuntz Crow, M.D., an immunity and inflammation specialist at the Hospital for Special Surgery in New York and 2008 chair of the ALR Scientific Advisory Board. The ALR approach of supporting investigations targeted toward developing new therapies for people with lupus is unique and meaningful.

Project co-Director Carl Langefeld, Ph.D., added, "These results suggest biologic pathways that help us understand the condition better and suggest additional genetic and non-genetic triggers. In addition, they will help delineate the genetic distinctions between rheumatoid arthritis, lupus and other autoimmune diseases, which could lead to earlier, more accurate diagnoses.

Langefeld, who is director of the Center for Public Health Genomics at Wake Forest University in Winston-Salem, N.C., also noted how satisfying the study results were. This is one of those things that, at the
'/>"/>

Contact: Sam Rogers
srogers@lupusresearch.org
646-884-6091
Alliance for Lupus Research
Source:Eurekalert

Page: 1 2

Related biology news :

1. Structure of 450 million year old protein reveals evolutions steps
2. Researchers take first steps towards spinal cord reconstruction following injury
3. Researchers move 2 steps closer to understanding genetic underpinnings of autism
4. Bursts of waves drive immune system soldiers toward invaders
5. MIT works toward safer gene therapy
6. A step toward tissue-engineered heart structures for children
7. Research points towards early cancer detection
8. Fish farms drive wild salmon populations toward extinction
9. MIT works toward engineered blood vessels
10. Proteins new role discovered in autoimmune disease
11. Antioxidant overload may underlie a heritable human disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2015)... June 24, 2015  Synaptics Inc. (NASDAQ: ... solutions, today announced that Sharp has selected its ... authentication for its latest flagship smartphone device, the ... 200 million shipments of its fingerprint ID sensor ... strength, scalability and leadership in the biometrics market ...
(Date:6/23/2015)... 23, 2015   MedNet Solutions , an ... entire spectrum of clinical research, is pleased to ... , the company,s intuitive, flexible and affordable cloud-based ... 2015 Stevie® Award by the American Business ... Website category.  The American Business Awards are considered ...
(Date:6/23/2015)... PALM BEACH GARDENS, Fla. , June ... of multi-factor identity management and authentication solutions, today ... Altus strong, multi-factor authentication solution.  The ... ease of use of the DigitalPersona Altus ... and biometric reader compatibility. In ...
Breaking Biology News(10 mins):Synaptics Brings Natural ID Technology to Sharp's Newest Flagship Smartphone 2MedNet Solutions' iMedNet eClinical Wins Silver Stevie Award 2Crossmatch Releases Enhanced DigitalPersona Altus Advanced Authentication Functionality 2
... curricula in US universities are sorely in need of reevaluation. ... Forward, to be held January 31 - February 2, a ... candid look at graduate physics programs and consider ways it ... physicists for future challenges. The conference, to be ...
... has published a novel method of using normalized spectral ... by mass spectrometry (APMS) to generate a probabilistic measure ... another. The work which allows ... interactions within well-defined protein assemblies, but also to interactions ...
... A new resource that identifies regions of the human genome ... develop treatments for a number of human diseases, according to ... The majority of DNA in our bodies is packaged, ... the IGSP and one of the senior investigators on this ...
Cached Biology News:Stowers Proteomics Center devises method for assigning probabilities to human protein interactions 2Search for the 'on' switches may reveal genetic role in development and disease 2
(Date:7/3/2015)... ... July 03, 2015 , ... The Alexander Group, a ... service industries alike-- typically known for its consummate professionalism-- embarks each year in ... and break from their day jobs. , "Our motto has always been work ...
(Date:7/3/2015)... 2015 Forskere kan ... in Science", som finner sted i ... nett, på  http://www.openinnovationinscience.at , og søknadsperioden varer ... De to største utfordringene innen helsevitenskapen er ... forskningsspørsmål og kompleksiteten av nåværende forskningsresultater, i ...
(Date:7/2/2015)... ... ... have been used in countless labs for decades. In the past, people had to ... expected, this was a daunting and tiring process looking at endless data tables and charts. ... navigate the complex catalog structure. , Now thanks to FireflySci, scientists are throwing away those ...
(Date:7/2/2015)... GLASGOW, Scotland , July 2, 2015 ...   Bio-tech procurement company Amici Procurement has ... IOM) to help it move to Office 365. ... Procurement provides small to medium-sized companies in the ... with all aspects of the purchasing cycle to help ...
Breaking Biology Technology:The Alexander Group Declares Their Independence with a Bit of Levity 2Lansering av verdens første Open Innovation-program for utdanning av forskere 2Lansering av verdens første Open Innovation-program for utdanning av forskere 3New Cuvette E-Commerce Website Launched by FireflySci 2Biotech Procurement Company Moves to Office 365 with iomart 2
... GeoVax Labs, Inc.,(OTC Bulletin Board: GOVX), an Atlanta-based, publicly ... (Human Immunodeficiency Virus) and other infectious agents, today,announced that ... Conference,2009 will be webcast live by Thomson Reuters. The ... York City on February 9 and 10, 2009. , ...
... the sale of International Fuel Technology, Inc. fuel additive formulations and ... the first year of its distribution agreement with IFT. , ... ... Fuel Technology, Inc. (IFT) (OTCBB: IFUE) announced that Multisol France ("Multisol") ...
... succeeded in significantly increasing the sensitivity of the new ... this topic at Delft University of Technology on Monday ... astronomers from around the world are currently working on ... 66 advanced telescopes which will be placed at an ...
Cached Biology Technology:GeoVax to Webcast Its Presentation at the BIO CEO & Investor 2009 Conference 2GeoVax to Webcast Its Presentation at the BIO CEO & Investor 2009 Conference 3Multisol France on Track to Sell 250 Tons of International Fuel Technology, Inc. Fuel Additive Formulations 2Multisol France on Track to Sell 250 Tons of International Fuel Technology, Inc. Fuel Additive Formulations 3Nanotechnology makes supertelescopes much more sensitive 2