Navigation Links
Steps toward Stopping Autoimmune Disease
Date:1/20/2008

NEW YORK, January 20, 2008A landmark genetic study has identified multiple genes linked to systemic lupus erythematosus (SLE), or lupus, a debilitating autoimmune disease that affects an estimated 1.4 million Americans.

Lupus can affect the joints, kidneys, heart, lungs, brain and blood and occurs in about 31 out of every 100,000 people. Women are nine times more likely than men to develop the condition, which is often difficult to diagnose.

In 2005 the Alliance for Lupus Research (ALR) formed and supported the International Systemic Lupus Erythematosus Genetics (SLEGEN) Consortium, charging scientists with searching for genetic variants that might predispose an individual to developing lupus.

Published in the January 20, 2008, issue of Nature Genetics, initial study results uncovered several genes linked to lupus and underscore the importance of genetic variants in diseases that affect immune function. The findings will ultimately lead to new therapies and earlier diagnosis.

The SLEGEN study is a model for collaborative genetic research, said Mary Kuntz Crow, M.D., an immunity and inflammation specialist at the Hospital for Special Surgery in New York and 2008 chair of the ALR Scientific Advisory Board. The ALR approach of supporting investigations targeted toward developing new therapies for people with lupus is unique and meaningful.

Project co-Director Carl Langefeld, Ph.D., added, "These results suggest biologic pathways that help us understand the condition better and suggest additional genetic and non-genetic triggers. In addition, they will help delineate the genetic distinctions between rheumatoid arthritis, lupus and other autoimmune diseases, which could lead to earlier, more accurate diagnoses.

Langefeld, who is director of the Center for Public Health Genomics at Wake Forest University in Winston-Salem, N.C., also noted how satisfying the study results were. This is one of those things that, at the end of your career, you can look back on and smile because you believe it will make a real difference.

SLEGEN Director John B. Harley, M.D., Ph.D., explained that the study found strong evidence of association with multiple single nucleotide polymorphisms (SNPs) in three genes: ITGAM; KIAA1542; PXK; and at SNP rs10798269, a DNA unit not found within any known gene. SNPs are chromosome locations where a single unit of DNA may vary from one person to another.

The results also showed evidence linking lupus to nine other genes. "I would have been satisfied with finding one gene. The fact that we present 13 strong candidates, supported by data that are 99% accurate is tremendous, added Harley, who heads the Arthritis & Immunology Research Program at the Oklahoma Medical Research Foundation in Oklahoma City.

Researchers studied the DNA of more than 6,700 women, including individuals with lupus, their family members and control subjects. Harley said they scanned the entire genome for more than 317,000 SNPs with the goal of identifying SNPs linked to lupus. "SLEGEN's purpose is to do the genomics," Harley said. "The mechanism of the disease by which these genes cause lupus will be seized upon by scientists who are expert in those pathways to develop new strategies for prevention and therapy and reduce the burden of suffering this disease causes." Langefeld said the accomplishments made in the SLEGEN research wouldn't have been possible without the support of ALR. "We simply would not have been able to do it without them."

We are very pleased to see the findings in print and are grateful that the ALR support for SLEGEN has had such a fruitful outcome, said Joseph E. Craft, M.D., chief of rheumatology at Yale University School of Medicine and former chair of the ALR Scientific Advisory Board.


'/>"/>

Contact: Sam Rogers
srogers@lupusresearch.org
646-884-6091
Alliance for Lupus Research
Source:Eurekalert

Related biology news :

1. Structure of 450 million year old protein reveals evolutions steps
2. Researchers take first steps towards spinal cord reconstruction following injury
3. Researchers move 2 steps closer to understanding genetic underpinnings of autism
4. Bursts of waves drive immune system soldiers toward invaders
5. MIT works toward safer gene therapy
6. A step toward tissue-engineered heart structures for children
7. Research points towards early cancer detection
8. Fish farms drive wild salmon populations toward extinction
9. MIT works toward engineered blood vessels
10. Proteins new role discovered in autoimmune disease
11. Antioxidant overload may underlie a heritable human disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/15/2016)... 2016 Transparency Market Research ... Market by Application Market - Global Industry Analysis Size Share ... the report, the  global gesture recognition market  was ... is estimated to grow at a CAGR of ... Increasing application of gesture recognition technology ...
(Date:6/7/2016)... , June 7, 2016  Syngrafii Inc. and ... business relationship that includes integrating Syngrafii,s patented LongPen™ ... project. This collaboration will result in greater convenience ... credit union, while maintaining existing document workflow and ... ...
(Date:6/2/2016)... NEW YORK , June 2, 2016   The ... (Weather), is announcing Watson Ads, an industry-first capability in which ... advertising, by being able to ask questions via voice or ... Marketers have long ... with the consumer, that can be personal, relevant and valuable; ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... Raleigh, NC (PRWEB) , ... June 24, 2016 , ... ... find the most commonly-identified miRNAs in people with peritoneal or pleural mesothelioma. Their findings ... here to read it now. , Diagnostic biomarkers are signposts in the blood, ...
(Date:6/23/2016)... /PRNewswire/ - FACIT has announced the creation of ... company, Propellon Therapeutics Inc. ("Propellon" or "the Company"), ... portfolio of first-in-class WDR5 inhibitors for the treatment ... represent an exciting class of therapies, possessing the ... cancer patients. Substantial advances have been achieved with ...
(Date:6/23/2016)...  The Prostate Cancer Foundation (PCF) is pleased to announce 24 ... for prostate cancer. Members of the Class of 2016 were selected from a ... Read More About the Class of 2016 PCF Young Investigators ... ... ...
(Date:6/23/2016)... ... June 23, 2016 , ... STACS DNA Inc., the sample ... the Arkansas State Crime Laboratory, has joined STACS DNA as a Field Application Specialist. ... said Jocelyn Tremblay, President and COO of STACS DNA. “In further expanding our capacity ...
Breaking Biology Technology: