Navigation Links
Step out for PAD
Date:12/14/2008

You probably know that poor diet and lack of exercise can lead to dangerous deposits of fatty plaques in arteries. But it is not just the heart that is affected blood flow can be blocked to the legs too, leading to pain when walking, immobility and even in extreme cases, amputation.

Approximately 20% of us will suffer from this peripheral artery disease (PAD) once we are 65 or over, and with risk factors including smoking, diabetes, obesity and high blood pressure it is on the rise. Surgical intervention can sometimes help, but the prognosis is not good.

Encouragingly, new research by Ronald Terjung et al1. published in The Journal of Physiology shows that regular, moderate exercise can go a long way to relieving the symptoms of PAD, and by some unexpected mechanisms.

When a major artery in the leg becomes blocked, the body naturally seeks another route for the blood to pass through by expanding and multiplying the surrounding smaller blood vessels in the area, called collateral blood flow.

The researchers studied rats with a blocked femoral artery and found that collateral blood flow was much more effective in restoring normal muscle function in rats that were put on regular exercise training.

The collateral vessels themselves were larger and less prone to constriction a problem exacerbated with PAD than in sedentary animals. Surprisingly, the function of blood vessels 'downstream' of the blockage also changed, making them more efficient.

The authors predict that a suitable exercise programme would delay the onset of pain and increase mobility for people suffering with PAD.

"Our findings raise the potential that new collateral vessels, that can develop in patients with PAD who are physically active, will function effectively to help minimize the consequences of the original vascular obstruction." commented Dr Terjung.


'/>"/>

Contact: Melanie Thomson
melanie.thomson@wiley.com
44-186-547-6270
Wiley-Blackwell
Source:Eurekalert

Page: 1

Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/12/2016)... May 12, 2016 WearablesResearch.com , a ... the overview results from the Q1 wave of its ... wave was consumers, receptivity to a program where they ... a health insurance company. "We were surprised ... says Michael LaColla , CEO of Troubadour Research, ...
(Date:4/28/2016)... 2016 First quarter 2016:   ... with the first quarter of 2015 The gross margin ... (loss: 18.8) and the operating margin was 40% (-13) ... Cash flow from operations was SEK 249.9 M (21.2) , ... unchanged, SEK 7,000-8,500 M. The operating margin for 2016 ...
(Date:4/15/2016)...  A new partnership announced today will help ... in a fraction of the time it takes ... life insurance policies to consumers without requiring inconvenient ... Diagnostics, rapid testing (A1C, Cotinine and HIV) and ... weight, pulse, BMI, and activity data) available at ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... 2016 /PRNewswire/ - FACIT has announced the creation ... biotechnology company, Propellon Therapeutics Inc. ("Propellon" or "the ... a portfolio of first-in-class WDR5 inhibitors for the ... WDR5 represent an exciting class of therapies, possessing ... for cancer patients. Substantial advances have been achieved ...
(Date:6/23/2016)... ... June 23, 2016 , ... Charm Sciences, Inc. is ... has received AOAC Research Institute approval 061601. , “This is another AOAC-RI approval ... Bob Salter, Vice President of Regulatory and Industrial Affairs. “The Peel Plate methods ...
(Date:6/23/2016)... --  EpiBiome , a precision microbiome engineering company, today ... from Silicon Valley Bank (SVB). The financing will allow ... drug development efforts, as well as purchase additional lab ... been an incredible strategic partner to us – one ... provide," said Dr. Aeron Tynes Hammack , EpiBiome,s ...
(Date:6/23/2016)... (PRWEB) , ... June 23, 2016 , ... In a ... Hospital in Denmark detail how a patient who developed lymphedema after being treated for ... The results could change the paradigm for dealing with this debilitating, frequent side effect ...
Breaking Biology Technology: