Navigation Links
Step forward in research into new treatments for brain edema
Date:3/19/2012

Cerebral edemas are accumulations of fluid into the intra- or extracellular spaces of the brain and it can result from several factors such as stroke or head trauma, among others.

Cerebral edema is a serious problem in neurology. While in other organs swelling does not lead to an urgent situation, in the brain it leads to coma and death. Although there are therapeutic solutions such as surgery, more effective treatments are needed.

Megalencephalic leukoencephalopathy with subcortical cysts (MLC) is a rare type of leukodystrophy (affects the white matter) of genetic origin. MLC can be considered as a model of chronic edema, as patients suffering from birth a high accumulation of water.

A study of the pathophysiology of this rare disease has uncovered one mechanism that destabilizes the homeostatic balance of brain cells causing edema. This study is published in the latest issue of the journal Neuron. The journal accompanies the paper with a commentary of the editor and an explanatory video on its website.

Researchers from IDIBELL, the University of Barcelona (UB) and CIBERER (Spanish Network Research Centre on Rare Diseases) have found that one function of the protein GlialCAM, which is genetically altered in patients with MLC, is to regulate the activity of the channel that allows the passage of chloride ions between brain cells to regulate ion and fluid balance.

When this protein is lacked, the channel is not working properly and the fluid builds up in the brain glial cells forming edema.

Raul Estevez, director of this work, and Virginia Nunes, a partner of the study, believe that the importance of this finding is twofold. "On one hand", explains Virginia Nunes, "it allows us to better understand the pathophysiology of this disease minority" and "on the other hand", Raul Estevez continues, "we have identified a mechanism that can open doors to treatments based on the activation of this channel to res
'/>"/>

Contact: Arantxa Mena
comunicacio@idibell.cat
IDIBELL-Bellvitge Biomedical Research Institute
Source:Eurekalert

Page: 1 2

Related biology news :

1. New technique is quantum leap forward in understanding proteins
2. How to move agriculture forward with limited water
3. Moving gene therapy forward with mobile DNA
4. Clinical trials for shingles drug take an important step forward
5. Another JDRF partner moves research forward with collaboration agreement for diabetes treatment
6. Step forward for nanotechnology: Controlled movement of molecules
7. First adhere, then detach and glide forward
8. Meteosat Third Generation takes a step forward
9. A fat forward research tool
10. CAKE offers way forward for climate change adaptation
11. Growing drought-tolerant crops inching forward
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/17/2014)... German . ... in order to reproduce? And why are there two sexes ... latest issue of the research journal Molecular Human Reproduction ... Ramm from Bielefeld University Bielefeld has compiled this special issue ... a female to copulate with several males in quick succession ...
(Date:10/16/2014)... and Washington land managers have a new synthesis of ... moist mixed-conifer (MMC) forests in the two states. ... in Eastern Oregon and Washington: A Synthesis of the ... a general technical report published by the U.S. Forest ... to a request from managers for a synthesis of ...
(Date:10/16/2014)... , October 16, 2014 NXT-ID, Inc. (NASDAQ: ... "Company"), a biometric authentication company focused on the growing ... edge technologies including Wocket™, the Smart Wallet, at the ... FiRe is a leading global conference on the intersection ... by Mark Anderson , founder and publisher of ...
Breaking Biology News(10 mins):Sperm wars 2New report synthesizes best available science on management of moist mixed-conifer forests 2NXT-ID Inc. to Present at 13th Annual FiRe Conference 2NXT-ID Inc. to Present at 13th Annual FiRe Conference 3
... MANHATTAN, Kan. -- What if you could shut down ... How about hacking a pacemaker and reprogramming it to ... scenes from an espionage film, they are also some ... experts are working to prevent. Eugene Vasserman, assistant ...
... cucumbers and other crops susceptible to infection by downy ... production costs thanks to collaborative research by Clemson University,s ... North Carolina State University. Anthony P. Keinath, professor ... Center in Charleston, recently was awarded a $40,000 USDA ...
... elk,s personality type is a big factor in whether or ... GPS collars on more than 100 male and female elk ... population could be divided into two categories: bold runners and ... moved quickly through the study area and preferred to graze ...
Cached Biology News:Internal relations 2Internal relations 3Internal relations 4Clemson plant pathologist working to raise cucurbit yields, lower production costs 2In elk hunting, success depends on the animal's personality 2
(Date:10/20/2014)... 2014 /PRNewswire/ - BIOREM Inc. (TSXV: BRM) ("Biorem" or "the Company") ... orders to $5.8 million and provides a good start to Q4.  ... North America and one in the Middle ... at record levels," said Peter Bruijns , President & CEO. ... of Q3 than they have been for any complete year since ...
(Date:10/20/2014)... N.J. (PRWEB) October 20, 2014 ... the Sidney Kimmel Cancer Center at Thomas Jefferson ... , Through the Strategic Alliance Partnership program, ... OncLive will collaborate to raise awareness of the ... treatment, and other projects. Clinicians and other health ...
(Date:10/19/2014)... 20, 2014 OCTOBER 20-22, ... (ABIM). ABIM will take place at ... about ABIM 2014 is now available at ... representing companies and organizations from all over ... information on the latest products and developments ...
(Date:10/19/2014)... The Asia-Pacific Speech Analytics market report ... with analysis and forecast of revenue. This market is ... $208 million by 2019, at a Compound Annual Growth ... Browse through the TOC of the Asia-Pacific Speech Analytics ... analysis provided. It also provides a glimpse of the ...
Breaking Biology Technology:Sidney Kimmel Cancer Center at Thomas Jefferson University Partners With OncLive 2Sidney Kimmel Cancer Center at Thomas Jefferson University Partners With OncLive 3The Asia-Pacific Speech Analytics market is estimated to reach $208 million by 2019 - New Report by MicroMarket Monitor 2The Asia-Pacific Speech Analytics market is estimated to reach $208 million by 2019 - New Report by MicroMarket Monitor 3The Asia-Pacific Speech Analytics market is estimated to reach $208 million by 2019 - New Report by MicroMarket Monitor 4
... 2012   Led by NUMODA CAPITAL INNOVATIONS, LLC., PINNACLE BIOLOGICS announced ... in a combination of Equity, and Debt Conversion. ... for Pinnacle Biologics. After completing the acquisition of ... Aptalis Pharma early last year, Pinnacle continues the ...
... Jan. 9, 2012 Exagen Diagnostics, Inc., ... and markets proprietary tests for rheumatologists and gastroenterologists, announced ... the diagnosis of lupus (Systemic Lupus Erythematosus). ... SLE and Rule-Out other rheumatic diseases to help establish ...
... Jan. 9, 2012 Chembio Diagnostics, Inc. (OTC.PK: ... and licenses point-of-care diagnostic tests, today announced that Lawrence ... at the Biotech Showcase in San Francisco at approximately ... Wednesday, January 11, 2012.   The conference ...
Cached Biology Technology:Pinnacle Biologics, Inc. Announces the Successful Completion of a Financing Round 2Pinnacle Biologics, Inc. Announces the Successful Completion of a Financing Round 3Exagen Diagnostics Launches Cutting-Edge Lupus Diagnostic 2Chembio Presenting at Biotech Conference 2Chembio Presenting at Biotech Conference 3
Cord blood endothelial progenitor cells, For immunohistochemistry (IHC) Cell Chip with Human Umbilical Cord Blood Progenitor Cells...
Umbilical cord blood CD14+ Monocytes, For immunohistochemistry (IHC) Cell Chip with Human Umbilical Cord Blood Monocytes, B Cells and NK Cells...
Human peripheral blood basophils, For immunohistochemistry (IHC) Cell Chip with Human Peripheral Blood Granulocytes...
Umbilical cord blood CD19+ B cells, For immunohistochemistry (IHC) Cell Chip with Human Umbilical Cord Blood Monocytes, B Cells and NK Cells...
Biology Products: