Navigation Links
Step forward in research into new treatments for brain edema
Date:3/19/2012

Cerebral edemas are accumulations of fluid into the intra- or extracellular spaces of the brain and it can result from several factors such as stroke or head trauma, among others.

Cerebral edema is a serious problem in neurology. While in other organs swelling does not lead to an urgent situation, in the brain it leads to coma and death. Although there are therapeutic solutions such as surgery, more effective treatments are needed.

Megalencephalic leukoencephalopathy with subcortical cysts (MLC) is a rare type of leukodystrophy (affects the white matter) of genetic origin. MLC can be considered as a model of chronic edema, as patients suffering from birth a high accumulation of water.

A study of the pathophysiology of this rare disease has uncovered one mechanism that destabilizes the homeostatic balance of brain cells causing edema. This study is published in the latest issue of the journal Neuron. The journal accompanies the paper with a commentary of the editor and an explanatory video on its website.

Researchers from IDIBELL, the University of Barcelona (UB) and CIBERER (Spanish Network Research Centre on Rare Diseases) have found that one function of the protein GlialCAM, which is genetically altered in patients with MLC, is to regulate the activity of the channel that allows the passage of chloride ions between brain cells to regulate ion and fluid balance.

When this protein is lacked, the channel is not working properly and the fluid builds up in the brain glial cells forming edema.

Raul Estevez, director of this work, and Virginia Nunes, a partner of the study, believe that the importance of this finding is twofold. "On one hand", explains Virginia Nunes, "it allows us to better understand the pathophysiology of this disease minority" and "on the other hand", Raul Estevez continues, "we have identified a mechanism that can open doors to treatments based on the activation of this channel to restore homeostatic balance and perhaps treat brain edema in general."

Both researchers agree to say that this case demonstrates that the investigation of a rare disease that affects a small proportion of the population can serve as a model to identify mechanisms to think of new treatments for common diseases.

MLC Leukodistophy

Megalencephalic Leukoencephalopathy with subcortical cysts (MLC) is a rare type of leukodystrophy that appears during the first year of life, characterized by macrocephaly (oversized head). A few years later, it appears a slow neurological deterioration with ataxia (lack of motor coordination) and spasms. Magnetic resonance techniques revealed inflammation of the cerebral white matter and subcortical cysts, particularly in the anterior temporal regions.

In the 75% of MLC patients it has been identified mutations in the gene MLC1, which cause the disease. Virginia Nunes and Raul Estevez have recently identified a second gene causing MLC, named GlialCAM.

In the present study they have been identified precisely a GlialCAM protein as an ion channel subunit chloride that allows its entering and exiting the brain so that the cells can regulate the homeostatic balance.


'/>"/>

Contact: Arantxa Mena
comunicacio@idibell.cat
IDIBELL-Bellvitge Biomedical Research Institute
Source:Eurekalert

Related biology news :

1. New technique is quantum leap forward in understanding proteins
2. How to move agriculture forward with limited water
3. Moving gene therapy forward with mobile DNA
4. Clinical trials for shingles drug take an important step forward
5. Another JDRF partner moves research forward with collaboration agreement for diabetes treatment
6. Step forward for nanotechnology: Controlled movement of molecules
7. First adhere, then detach and glide forward
8. Meteosat Third Generation takes a step forward
9. A fat forward research tool
10. CAKE offers way forward for climate change adaptation
11. Growing drought-tolerant crops inching forward
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2017)... report "Gesture Recognition and Touchless Sensing Market by Technology (Touch-based and Touchless), Product ... by MarketsandMarkets, the market is expected to be worth USD 18.98 billion by ... Continue Reading ... ...      (Logo: http://photos.prnewswire.com/prnh/20160303/792302) ...
(Date:3/22/2017)... Vigilant Solutions , a vehicle location ... announced today the appointment of retired FBI special agent ... business development. Mr. Sheridan brings more than ... focus on the aviation transportation sector, to his new ... Sheridan served as the Aviation Liaison Agent Coordinator (ALAC) ...
(Date:3/13/2017)... -- Future of security: Biometric Face Matching software  ... ... Face Matching enables to match face pictures against each other or against large ... Identification Systems) ... is the fastest software for biometric Face Matching on the market. The speed ...
Breaking Biology News(10 mins):
(Date:3/29/2017)... ... March 29, 2017 , ... Cancer ... exhibiting in booth 513 at the Association of Community Cancer Centers (ACCC) 43rd ... 29-31. , CANCERSCAPE unites key stakeholders from leading national organizations to share ...
(Date:3/29/2017)... 2017 Research and Markets has announced the ... - Industry Forecast to 2025" report to their offering. ... The Global Agricultural ... 7.8% over the next decade to reach approximately $825.4 million by ... and forecasts for all the given segments on global as well ...
(Date:3/29/2017)... MO , March 29, 2017 /PRNewswire/ - The ... its partners Nordion, a business of Sterigenics International, and ... (LAR) has been submitted to the U.S. Nuclear Regulatory ... domestic U.S. production of molybdenum-99 (Mo-99). Once operational, production ... half of U.S. demand for Mo-99, which currently must ...
(Date:3/29/2017)... , Mar. 29, 2017 Research ... Biotechnology: Emerging Technologies and Global Markets" report to their ... ... next generation DNA sequencing, biochips, RNA interference, synthetic biology tools ... seeds; and biologicals. These technologies and products are ...
Breaking Biology Technology: