Navigation Links
Stem cells to treat lung disease in preterm infants

Cincinnati, OH, February 6, 2014 -- Advances in neonatal care for very preterm infants have greatly increased the chances of survival for these fragile infants. However, preterm infants have an increased risk of developing bronchopulmonary dysplasia (BPD), a serious lung disease, which is a major cause of death and lifelong complications. In a new study scheduled for publication in The Journal of Pediatrics, researchers evaluated the safety and feasibility of using stem cell therapies on very preterm infants to prevent or treat BPD.

Won Soon Park, MD, PhD, and colleagues from Samsung Medical Center and Biomedical Research Institute, Seoul, Republic of Korea, conducted a phase I, single-center trial of intratracheal transplantation of human umbilical cord blood-derived mesenchymal stem cells to nine very preterm infants (24-26 weeks gestational age) who were at high risk of developing BPD.

All patients who received the treatment tolerated the procedure well without any immediate serious adverse effects. Thirty-three percent of treated infants developed moderate BPD and none developed severe BPD, and 72 percent of a matched comparison group developed moderate or severe BPD. Another serious side effect of very preterm birth, retinopathy of prematurity requiring surgery, tended to occur less often in treated infants. Overall, all nine treated infants survived to discharge, and only three developed moderate BPD.

This phase I study suggests that intratracheal administration of mesenchymal stem cells is safe and feasible. According to Dr. Park, "These findings strongly suggest that phase II clinical trials are warranted to test the efficacy of mesencymal stem cell transplantation, which could lead to new therapies to prevent or cure BPD." Dr. Park and colleagues are currently conducting a long-term safety and follow-up study of these nine preterm infants ( NCT01632475).


Contact: Becky Lindeman
Elsevier Health Sciences

Related biology news :

1. In vitro innovation: Testing nanomedicine with blood cells on a microchip
2. Researchers reverse some lung diseases in mice by coaxing production of healthy cells
3. Engineered virus is effective against triple negative breast cancer cells
4. Scientists discover that thyroid cancer cells become less aggressive in outer space
5. New method increases supply of embryonic stem cells
6. Long-lived breast stem cells could retain cancer legacy
7. FASEB announces 2014 Science Research Conference: Skeletal Muscle Satellite and Stem Cells
8. UT Austin engineer converts yeast cells into sweet crude biofuel
9. FAK helps tumor cells enter the bloodstream
10. Little but lethal -- small RNAs coordinate bacterial attack on epithelial cells
11. Harvard scientists control cells following transplantation, from the inside out
Post Your Comments:
(Date:10/29/2015)... , Oct. 29, 2015 Daon, a ... that it has released a new version of its ... in North America have already ... v4.0 also includes a FIDO UAF certified server ... already preparing to activate FIDO features. These customers include ...
(Date:10/27/2015)... Oct. 27, 2015 In the present market ... concern for various industry verticals such as banking, healthcare, ... the growing demand for secure & simplified access control ... such as hacking of bank accounts, misuse of users, ... such as PC,s, laptops, and smartphones are expected to ...
(Date:10/26/2015)... Calif. , Oct. 26, 2015  Delta ID ... biometric authentication to mobile and PC devices, announced its ... smartphone, the arrows NX F-02H launched by NTT DOCOMO, ... NX F-02H is the second smartphone to include iris ... technology in ARROWS NX F-04G in May 2015, world,s ...
Breaking Biology News(10 mins):
(Date:11/30/2015)... 1, 2015  An interventional radiology technique shows promise for ... results of a study being presented today at the annual ... (RSNA). --> ... by interventional radiologists as a way to stop bleeding in ... a means of treating obesity is new. Mubin ...
(Date:11/30/2015)... Mass. , Nov. 30, 2015 ... HART ), a biotechnology company developing bioengineered organ ... received written notification from The NASDAQ Stock Market ... bid price requirements. The letter noted that as ... HART,s common stock having exceeded $1.00 per share ...
(Date:11/30/2015)... N.J. , Nov. 30, 2015  Champions Oncology, ... solutions and services to personalize the development and use ... , Chief Executive Officer, will be presenting at the ... at 4:30pm Pacific Standard Time (PST).  The conference, held ... Los Angeles, CA , will feature 200 ...
(Date:11/30/2015)... 2015  Aytu BioScience, Inc. (OTCQB: AYTU), a commercial-stage ... will present at two upcoming investor conferences. Aytu is ... virtual conference, to be held December 3, 2015, and ... held December 2 nd & 3 rd , ... streamed live via webcast. Josh Disbrow , ...
Breaking Biology Technology: