Navigation Links
Stem cells to treat lung disease in preterm infants
Date:2/5/2014

Cincinnati, OH, February 6, 2014 -- Advances in neonatal care for very preterm infants have greatly increased the chances of survival for these fragile infants. However, preterm infants have an increased risk of developing bronchopulmonary dysplasia (BPD), a serious lung disease, which is a major cause of death and lifelong complications. In a new study scheduled for publication in The Journal of Pediatrics, researchers evaluated the safety and feasibility of using stem cell therapies on very preterm infants to prevent or treat BPD.

Won Soon Park, MD, PhD, and colleagues from Samsung Medical Center and Biomedical Research Institute, Seoul, Republic of Korea, conducted a phase I, single-center trial of intratracheal transplantation of human umbilical cord blood-derived mesenchymal stem cells to nine very preterm infants (24-26 weeks gestational age) who were at high risk of developing BPD.

All patients who received the treatment tolerated the procedure well without any immediate serious adverse effects. Thirty-three percent of treated infants developed moderate BPD and none developed severe BPD, and 72 percent of a matched comparison group developed moderate or severe BPD. Another serious side effect of very preterm birth, retinopathy of prematurity requiring surgery, tended to occur less often in treated infants. Overall, all nine treated infants survived to discharge, and only three developed moderate BPD.

This phase I study suggests that intratracheal administration of mesenchymal stem cells is safe and feasible. According to Dr. Park, "These findings strongly suggest that phase II clinical trials are warranted to test the efficacy of mesencymal stem cell transplantation, which could lead to new therapies to prevent or cure BPD." Dr. Park and colleagues are currently conducting a long-term safety and follow-up study of these nine preterm infants (ClinicalTrials.gov: NCT01632475).


'/>"/>

Contact: Becky Lindeman
journal.pediatrics@cchmc.org
513-636-7140
Elsevier Health Sciences
Source:Eurekalert

Related biology news :

1. In vitro innovation: Testing nanomedicine with blood cells on a microchip
2. Researchers reverse some lung diseases in mice by coaxing production of healthy cells
3. Engineered virus is effective against triple negative breast cancer cells
4. Scientists discover that thyroid cancer cells become less aggressive in outer space
5. New method increases supply of embryonic stem cells
6. Long-lived breast stem cells could retain cancer legacy
7. FASEB announces 2014 Science Research Conference: Skeletal Muscle Satellite and Stem Cells
8. UT Austin engineer converts yeast cells into sweet crude biofuel
9. FAK helps tumor cells enter the bloodstream
10. Little but lethal -- small RNAs coordinate bacterial attack on epithelial cells
11. Harvard scientists control cells following transplantation, from the inside out
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2017)... MELBOURNE, Florida , April 17, 2017 ... security technology company, announces the filing of its 2016 Annual Report ... Securities and Exchange Commission. ... Report on Form 10-K is available in the Investor Relations section ... well as on the SEC,s website at http://www.sec.gov . ...
(Date:4/13/2017)... PUNE, India , April 13, 2017 According ... Identity Proofing, Identity Authentication, Identity Analytics, Identity Administration, and Authorization), Service, Authentication ... by MarketsandMarkets™, the IAM Market is expected to grow from USD 14.30 ... Annual Growth Rate (CAGR) of 17.3%. ... ...
(Date:4/11/2017)... Research and Markets has announced the addition ... their offering. ... tracking market to grow at a CAGR of 30.37% during the ... 2017-2021, has been prepared based on an in-depth market analysis with ... its growth prospects over the coming years. The report also includes ...
Breaking Biology News(10 mins):
(Date:5/23/2017)... CA (PRWEB) , ... May 23, 2017 , ... ... publication of “Label-free isolation of prostate circulating tumor cells using Vortex microfluidic technology ... the result of a collaboration with Dr. Dino Di Carlo and Dr. Matthew Rettig ...
(Date:5/23/2017)... (PRWEB) , ... May 23, 2017 , ... ... Works as Vice President of Clinical Operations. She brings years of expertise ... Yaupon Therapeutics. From her professional foundation as a licensed occupational therapist, through a ...
(Date:5/23/2017)... ... , ... Cambridge Semantics , the leading provider of Big Data management ... and Expo in Boston May 23-25 with a featured speaker and solution demos ... Lake is also a finalist for the Best of Show award. , James LaPointe, ...
(Date:5/22/2017)... ... May 22, 2017 , ... Stratevi, a boutique firm ... the East Coast. It has opened an office in downtown Boston at 745 Atlantic ... it increasingly more important to generate evidence on the value they provide, not just ...
Breaking Biology Technology: