Navigation Links
Stem cells show promise in repairing a child's heart
Date:1/27/2011

Visionaries in the field of cardiac therapeutics have long looked to the future when a damaged heart could be rebuilt or repaired by using one's own heart cells. A study published in the February issue of Circulation, a scientific journal of the American Heart Association, shows that heart stem cells from children with congenital heart disease were able to rebuild the damaged heart in the laboratory.

Sunjay Kaushal, MD, PhD, surgeon in the Division of Cardiovascular Thoracic Surgery at Children's Memorial Hospital and assistant professor of surgery at Northwestern University Feinberg School of Medicine, who headed the study, believes these results show great promise for the growing number of children with congenital heart problems. With this potential therapy option these children may avoid the need for a heart transplant.

"Due to the advances in surgical and medical therapies, many children born with cardiomyopathy or other congenital heart defects are living longer but may eventually succumb to heart failure," said Kaushal. "This project has generated important pre-clinical laboratory data showing that we may be able to use the patient's own heart stem cells to rebuild their hearts, allowing these children to potentially live longer and have more productive lives."

Cells were obtained from patients ranging in age from a few days after birth to 13 years who were undergoing routine congenital cardiac surgery. Findings show that the number of heart stem cells was greatest in neonates and then rapidly decreased with age, and that the highest numbers of these stem cells are located in the upper right chamber of the heart, or the right atrium. The study also showed that the cardiac stem cells are functional and have the potential for use in repairing the damaged heart. Up until now, heart stem cell studies have addressed the adult diseased heart, but this is the first and largest systematic study to focus on children.

"Heart disease in children is different than heart disease in adults," said Kaushal. "Whereas adults might suffer heart failure from coronary artery disease or atherosclerosis, heart failure in children primarily occurs because they acquire cardiomyopathy or have a congenital condition in which the heart chambers are small or in the wrong position causing the heart to pump inefficiently. The potential of cardiac stem cell therapy for children is truly exciting," said Kaushal. Pending FDA approval, Kaushal hopes to begin clinical trials with children in the fall.


'/>"/>

Contact: Julie Pesch
jpesch@childrensmemorial.org
773-880-3055
Children's Memorial Hospital
Source:Eurekalert

Related biology news :

1. Using a childs own stem cells to repair their heart looks promising
2. Research suggests HIV causes rapid aging in key infection-fighting cells
3. New anti-HIV gene therapy makes T-cells resistant to HIV infection
4. Caffeine energizes cells, boosting virus production for gene therapy applications
5. Conversion of brain tumor cells into blood vessels thwarts treatment efforts
6. New molecule could save brain cells from neurodegeneration, stroke
7. Massive endocytosis in cells
8. Scientists find the master switch for key immune cells in inflammatory diseases
9. MicroRNA suppresses prostate cancer stem cells and metastasis
10. Early investigations promising for detecting metastatic breast cancer cells
11. Researchers investigate why a limited number of white blood cells are attracted to injured tissue
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/15/2016)... LONDON , Dec. 15, 2016 /PRNewswire/ ... the driving experience, health wellness and wellbeing ... As one in three new passenger vehicles ... voice recognition, gesture recognition, heart beat monitoring, ... eyelid monitoring, facial monitoring, and pulse detection. ...
(Date:12/12/2016)... -- Researchers at Trinity College, Dublin, are opening up ... material with Silly Putty. The mixture (known as "G-putty") ... sense pulse, blood pressure, respiration, and even the ... The research team,s findings were published Thursday in ... Due ...
(Date:12/7/2016)... 2016 According to a new market research report "Emotion ... Expression, Voice Recognition), Service, Application Area, End User, And Region - Global Forecast ... USD 6.72 Billion in 2016 to USD 36.07 Billion by 2021, at a ... Reading ... MarketsandMarkets Logo ...
Breaking Biology News(10 mins):
(Date:1/21/2017)... (PRWEB) , ... January 20, 2017 , ... ... consulting and resource to the healthcare industry ( http://www.gandlscientific.com ), has announced the ... expanding team of clinical and scientific consultants and contractors. This is the latest ...
(Date:1/21/2017)... N.J. , Jan. 20, 2017 ... "Company"), a company that provides clinically useful molecular ... it has entered into a securities purchase agreement ... of 855,000 shares of common stock in a ... the Company has agreed to sell to the ...
(Date:1/21/2017)... , Jan. 21, 2017   Boston Biomedical ... compounds designed to target cancer stemness pathways, today presented ... compound, napabucasin, at the 2017 American Society of Clinical ... Francisco . In a Phase ... agent designed to inhibit cancer stemness pathways by targeting ...
(Date:1/20/2017)... , Jan. 20, 2017 Ginkgo Bioworks, ... Gen9, a pioneer in the synthesis and assembly ... expertise in assembling pathway-length synthetic DNA into Ginkgo,s ... capacity in the construction of new organism designs ... "Gen9 was founded to significantly increase ...
Breaking Biology Technology: