Navigation Links
Stem cells shape up to their surroundings
Date:10/7/2010

oscale grooves, pits and ridges, and are particularly sensitive to the spacing and regularity of these features.

Nanotopographical responsiveness has been observed in diverse cell types including fibroblasts, osteoblasts, osteoclasts, endothelial, smooth muscle, epithelial, and epitenon cells. "This is intriguing from a biomaterials perspective," says McNamara, "as it demonstrates that surface features of just a few nanometres can influence how cells will respond to, and form tissue on, materials."

Stem cells detect surface features with a variety of mechanosensors, including integrin-linked focal adhesions. These respond to the mechanical constraints of the surface by inducing signalling cascades, such as the ERK-MAPK pathway. When the cell's rearranging cytoskeleton physically pulls on components of the cell's nucleus, this force works together with chemical signalling. Together these indirect (biochemical signal-mediated) and direct (force-mediated) factors can modulate nuclear components, altering gene expression to direct stem cell responses.

One interesting finding has been that topography can in some cases have the same effect as biochemical differentiation factors. The potential to eliminate the need for the latter opens the door to development of improved clinical prostheses with topographies that can directly modulate stem cell fate. In particular, the authors envisage applications involving engineered topography components for stem cells in regenerative medicine, for instance, in orthopaedics and dental implants. A combination of different topographies could be used to differentially functionalise implants for distinct applications, or demarcate particular "zones" within a single device.

Orthopaedic implants designed with specific regions tailored to integrate with bone and improve the chances of implant fixation might be seamlessly join other areas of the implant programmed to reduce excessive bony ingrowth, for exa
'/>"/>

Contact: Jayne Fairley
jayne.fairley@sagepub.co.uk
020-732-48719
SAGE Publications UK
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Jefferson scientists deliver toxic genes to effectively kill pancreatic cancer cells
2. NSF funds new Center for the Physics of Living Cells at Illinois
3. When cells go bad
4. The role of stem cells in renewing the cornea
5. Breast cancer cells recycle to escape death by hormonal therapy
6. Models of eel cells suggest electrifying possibilities
7. Scientists identify a molecule that coordinates the movement of cells
8. Form of Crohns disease traced to disabled gut cells
9. Cold Spring Harbor Laboratory scientists trace a novel way cells are disrupted in cancer
10. Researchers design artificial cells that could power medical implants
11. Stabilizing force for good communication between neurons and muscle cells found
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/12/2014)... an active role in the destruction and remodelling ... being an ,innocent bystander, as previously thought. , ... Lawler, Dr Ben Croker and colleagues from the ... while investigating the role of the protein SOCS3 ... was published in the journal Arthritis and ...
(Date:9/12/2014)... coccidiosis is a serious parasitic infection of young ... to diarrhoea and reduced nutritional intake. As the ... can result in increased mortality, the disease is ... farms., "The developing immune system of neonatal piglets ... the parasites. For this reason, an infection shortly ...
(Date:9/11/2014)... with autism often show a reduced frequency of ... in repetitive solitary behaviors. Autism has also been ... structure involved in processing emotions. Now Caltech researchers ... amygdala that control whether the animal engages in ... may have implications for understanding neural circuit dysfunctions ...
Breaking Biology News(10 mins):No innocent bystander: Cartilage contributes to arthritis 2Piglet health 2Piglet health 3Tipping the balance of behavior 2Tipping the balance of behavior 3
... the late 1800s, a flurry of fossil speculation across the ... Bone Wars. Drawn into the spectacle were two scientists ... acclaimed as the Father of Texas Geology, and naturalist Jacob ... Hill and Boll had supporting roles in the Bone ...
... to the amount of unhealthy foods they eat, but can ... new study in the Journal of Consumer Research . ... willpower and desire, consumers can,t rely entirely on willpower to ... will make them lose interest in food. One way is ...
... side-effects caused by the anti-parasitic drug quinine in the treatment ... The research, carried out by Nottingham scientists on the University,s ... in our levels of the amino acid, tryptophan, has a ... appears that the lower our levels of tryptophan the more ...
Cached Biology News:Newly discovered letters and translated German ode expand Texas link to infamous Bone Wars 2Newly discovered letters and translated German ode expand Texas link to infamous Bone Wars 3Newly discovered letters and translated German ode expand Texas link to infamous Bone Wars 4Newly discovered letters and translated German ode expand Texas link to infamous Bone Wars 5Eat dessert first? It might help you control your diet 2Diet could combat adverse side-effects of quinine 2Diet could combat adverse side-effects of quinine 3
(Date:9/11/2014)... 2014 The Registration Committee today ... now open for Pittcon 2015, the world’s largest ... event will be held March 8-12, 2015, at ... , The discounted registration fee of $175 ... 2/20/2015). This affordable price includes unlimited week-long access ...
(Date:9/11/2014)... September 11, 2014 ... production of its biocompatible, non-toxic and non-leaching antimicrobial Sanipolymers™. ... as one of the top tech startups of ... biomimetics to create antimicrobial plastics. Consumers are ... touch surfaces use hazardous substances. These substances or additives ...
(Date:9/11/2014)... (PRWEB) September 11, 2014 DuPont ... excited to announce that it has appointed ... two wholly owned subsidiaries, Essex Grain Products ... of Zemea® USP propanediol in the food and ... following USA eastern and mid-western states: Alabama, ...
(Date:9/10/2014)... 11, 2014 Daten ... der Jahresversammlung der Europäischen Gesellschaft für gynäkologische ... Tumorprofilierung als "Wendepunkt" für Onkologen. ... ein deutlich längeres Überleben nach der Profilierung ... peritonealem Krebs, denen Behandlungen verabreicht wurden, die ...
Breaking Biology Technology:Conferee Registration Opens for Pittcon 2015; Housing & Travel Open for Reservations 2World's First Biocompatible and Non-toxic Antibacterial Plastic 2DuPont Tate & Lyle Bio Products Appoints Skidmore Sales as Distributor for Zemea® USP 2DuPont Tate & Lyle Bio Products Appoints Skidmore Sales as Distributor for Zemea® USP 3Verbesserte Überlebensrate von Patientinnen mit Eierstockkrebs, die Behandlungen nach Anleitung durch komplette Tumorprofilierung erhalten 2Verbesserte Überlebensrate von Patientinnen mit Eierstockkrebs, die Behandlungen nach Anleitung durch komplette Tumorprofilierung erhalten 3Verbesserte Überlebensrate von Patientinnen mit Eierstockkrebs, die Behandlungen nach Anleitung durch komplette Tumorprofilierung erhalten 4Verbesserte Überlebensrate von Patientinnen mit Eierstockkrebs, die Behandlungen nach Anleitung durch komplette Tumorprofilierung erhalten 5
... Ocean energy company, BioPower Systems (BPS), today announced ... Hon. Michael O,Brien MP, has awarded the company conditional ... Pilot Demonstration Program. The funding will be ... company,s 250kW bioWAVE ocean wave energy system at a ...
... RSB Spine announced today that it received a revised ... an interbody implant with integrated fixation and an anterior ... for stand-alone interbody devices with integrated fixation.   The new ... new code for cervical interbody devices is OVE.   In ...
... 30, 2011  Nutra Pharma Corporation (OTCBB: NPHC), a biotechnology ... Human Immunodeficiency Virus (HIV), Adrenomyeloneuropathy (AMN) and Pain, announced ... publishing a mechanism study on the use of Alpha-Cobratoxin, ... pain. The paper was co-authored by Paul Reid, PhD ...
Cached Biology Technology:BioPower Systems Awarded $5 Million from Victorian Government 2BioPower Systems Awarded $5 Million from Victorian Government 3FDA Establishes New Product Codes for Interbody Devices With Integrated Fixation 2Nutra Pharma Announces Publication of a New Mechanism Study of Alpha-Cobratoxin in the Treatment of Pain 2Nutra Pharma Announces Publication of a New Mechanism Study of Alpha-Cobratoxin in the Treatment of Pain 3
ID clarifier: non-treated with lid...
... Series of systems provide fast and reliable scalable automation ... development laboratories. Staccato systems are available in three base ... Series. ... All Staccato Application ...
... provide fast and reliable automation for ... drug development laboratories. Staccato Custom Series ... providing solutions that are tailored to ... Systems are controlled with either Caliper's ...
... Use in any standard fixed-angle microcentrifuge ... g.,Spin- centrifuge tube filters consist ... a centrifuge tube. They filter by ... HPLC sample preparation, removal of cells ...
Biology Products: