Navigation Links
Stem cells restore cognitive abilities impaired by brain cancer treatment
Date:7/13/2011

Irvine, Calif., July 13, 2011 Human neural stem cells are capable of helping people regain learning and memory abilities lost due to radiation treatment for brain tumors, a UC Irvine study suggests.

Research with rats found that stem cells transplanted two days after cranial irradiation restored cognitive function, as measured in one- and four-month assessments. In contrast, irradiated rats not treated with stem cells showed no cognitive improvement.

"Our findings provide solid evidence that such cells can be used to reverse radiation-induced damage of healthy tissue in the brain," said Charles Limoli, a UCI radiation oncology professor.

Study results appear in the July 15 issue of Cancer Research, a journal of the American Association for Cancer Research.

Radiotherapy for brain tumors is limited by how well the surrounding tissue tolerates it. Patients receiving radiation at effective levels suffer varying degrees of learning and memory loss that can adversely affect their quality of life.

"In almost every instance, people experience severe cognitive impairment that's progressive and debilitating," Limoli said. "Pediatric cancer patients can experience a drop of up to three IQ points per year."

For the UCI study, multipotent human neural stem cells were transplanted into the brains of rats that had undergone radiation treatment. They migrated throughout the hippocampus a region known for the growth of new neurons and developed into brain cells.

Researchers assessed the rats one month and four months after transplantation, noting enhanced learning and memory abilities at both intervals.

Additionally, they found that transplanting as few as 100,000 human neural stem cells was sufficient to improve cognition after cranial irradiation. Of cells surviving the process, about 15 percent turned into new neurons, while another 45 percent became astrocytes and oligodendrocytes cells th
'/>"/>

Contact: Tom Vasich
tmvasich@uci.edu
949-824-6455
University of California - Irvine
Source:Eurekalert

Page: 1 2

Related biology news :

1. Deeper insight in the activity of cortical cells
2. Sertoli cells show promise for therapeutics
3. Scientists discover how best to excite brain cells
4. Unnatural chemical allows Salk researchers to watch protein action in brain cells
5. Scientists devise way to sort brain cells for potential transplants
6. Researchers characterize biomechanics of ovarian cells according to phenotype at stages of cancer
7. New technique advances bioprinting of cells
8. Mutations can spur dangerous identity crisis in cells
9. Adult stem cells carry their own baggage: Epigenetics guides stem cell fate
10. Rogue blood cells may contribute to post-surgery organ damage
11. Johns Hopkins scientists expose cancer cells universal dark matter
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/25/2014)... puberty is influenced by ,imprinted genes,a subset of genes whose ... This is the first evidence that imprinted genes can control ... study were published today in the journal Nature . ... a marker for the timing of puberty in females. ... girls, is an inherited trait, and is linked to breast ...
(Date:7/25/2014)... CORAL SPRINGS, Florida , July 25, 2014 /PRNewswire/ ... influential as more consumers are turning to digital technology ... NXT-ID, Inc. (OTCBB: NXTD), Google Inc. (NASDAQ: ... Visa Inc. (NYSE: V ), Apple Inc. ... FTNT) NXT-ID, Inc., (OTCQB: NXTD) a biometric ...
(Date:7/24/2014)... DIEGO , July 24, 2014 /PRNewswire-iReach/ -- The ... data from cardiac devices, has cut emergency room wait ... UC San Diego (UCSD) Medical Center, according to a ... The UCSD Emergency Departments are using the suite to ... as pacemakers or defibrillators. "Using Geneva,s technology ...
Breaking Biology News(10 mins):Could age of first period influence development of diseases in older women? 2Consumer Needs for Identity Theft Security Grows with Popularity of Latest Smart Technology Products - Biometrically Secure Digital Wallet to Replace Credit Card Dependency 2Consumer Needs for Identity Theft Security Grows with Popularity of Latest Smart Technology Products - Biometrically Secure Digital Wallet to Replace Credit Card Dependency 3Consumer Needs for Identity Theft Security Grows with Popularity of Latest Smart Technology Products - Biometrically Secure Digital Wallet to Replace Credit Card Dependency 4Consumer Needs for Identity Theft Security Grows with Popularity of Latest Smart Technology Products - Biometrically Secure Digital Wallet to Replace Credit Card Dependency 5Consumer Needs for Identity Theft Security Grows with Popularity of Latest Smart Technology Products - Biometrically Secure Digital Wallet to Replace Credit Card Dependency 6UC San Diego Medical Center Cuts Average ER Wait Time by 92 Minutes using the Geneva Healthcare Suite 2UC San Diego Medical Center Cuts Average ER Wait Time by 92 Minutes using the Geneva Healthcare Suite 3
... In most animal species, males and females show obvious differences ... both sexes share the same genes governing their growth? University ... clues that had been overlooked by previous efforts to explain ... the animal world and you will find that, in most ...
... collective efforts to develop new drugs, the pharmaceuticals industry ... application of natural biological transformation processes. One of the ... cells in a bioreactor filled with a liquid culture ... regulations, the conditions inside the bioreactor need to be ...
... science disciplines recently gathered to address a major question: ... Of course, possible answers to this question raise ... were to alter local vegetation, how would this new ... with certainty would allow us to manage better our ...
Cached Biology News:Why female moths are big and beautiful 2Why female moths are big and beautiful 3Clean sampling from bioreactors 2Networking initiative to support interdisciplinary research 2Networking initiative to support interdisciplinary research 3
(Date:7/24/2014)... Quantum computers have yet to materialise. Yet, scientists ... making such computers faster. One such approach relies ... controlled by applying an electric field. A new ... coherently coupled quantum dots (TQDs) with electrical impulses ... for example, should TQDs be used as quantum ...
(Date:7/24/2014)... , July 24, 2014 Research ... "Global Cell Culture Market 2014-2018" report to ... Cell culture is the in vitro growth ... as research, cell studies, and biopharmaceutical production. Cell culture ... production. Cell culture instruments and cell culture consumables are ...
(Date:7/24/2014)... , July 24, 2014 SRI International has ... the National Institute of Allergy and Infectious Diseases (NIAID), ... preclinical development of potential therapies for HIV infection and ... treat HIV and AIDS and the complications and opportunistic ... for preventing sexual transmission of HIV. ...
(Date:7/24/2014)... 24, 2014 2014 Deep Research ... is a professional and in-depth research report on ... Sulphate basic information, including its definition, classification, ... This research covers the international market analysis, including ... analysis covering macroeconomic environment & economic situation analysis, ...
Breaking Biology Technology:Global Cell Culture Market 2014-2018: Key Vendors are Becton, Dickinson and Co, EMD, GE Healthcare, Lonza Group, Sigma Aldrich and Thermo Fisher Scientific 2National Institute of Allergy and Infectious Diseases Awards SRI International Contract to Study New Therapies for HIV and AIDS 2National Institute of Allergy and Infectious Diseases Awards SRI International Contract to Study New Therapies for HIV and AIDS 3Potassium Sulphate Market & SHMP Industry 2014 (Global, China) Analysis Now Available at DeepResearchReports.com 2Potassium Sulphate Market & SHMP Industry 2014 (Global, China) Analysis Now Available at DeepResearchReports.com 3Potassium Sulphate Market & SHMP Industry 2014 (Global, China) Analysis Now Available at DeepResearchReports.com 4
... Inc. (Nasdaq: VRUS ), a clinical ... commercializing novel drugs to treat viral infections, reported ... quarter ended December 31, 2008. Financial Results ... quarters ended December 31, 2008 and December 31, ...
... Vitro Technologies (Celsis,IVT), a division of Celsis International ... company, and Wisconsin-based Promega Corp,will take the trial ... Celsis IVT is pre-qualifying lots of its ... assays, including,the P450-Glo(TM) CYP Assay used to study ...
... the Clinical and Economic Value of Pharmaceuticals in ... ExL Pharma today announced the start of the ... Marketing for the Pharmaceutical Industry at the Loews ... markets marketers with strategic insights needed to prepare ...
Cached Biology Technology:Pharmasset Reports Fiscal First Quarter 2009 Financial Results 2Pharmasset Reports Fiscal First Quarter 2009 Financial Results 3Pharmasset Reports Fiscal First Quarter 2009 Financial Results 4Pharmasset Reports Fiscal First Quarter 2009 Financial Results 5Pharmasset Reports Fiscal First Quarter 2009 Financial Results 6Pharmasset Reports Fiscal First Quarter 2009 Financial Results 7Pharmasset Reports Fiscal First Quarter 2009 Financial Results 8Celsis In Vitro Technologies and Promega to Offer Fast, Reliable Solutions for ADME-Tox Testing With Primary Hepatocytes 2Celsis In Vitro Technologies and Promega to Offer Fast, Reliable Solutions for ADME-Tox Testing With Primary Hepatocytes 3ExL Pharma Presents The Pharmaceutical Managed Markets Insight & Marketing for the Pharmaceutical Industry Conference 2ExL Pharma Presents The Pharmaceutical Managed Markets Insight & Marketing for the Pharmaceutical Industry Conference 3
Preparation Note: Prepared by method of Wimmer, E., et al., Biochemistry, 7, 2623 (1968). Quality Clarifier: Acceptor Activity: approx. 1000 picomoles phenylalanine per A 260 unit (not determined b...
... which is based on a new flow-through technology, ... in situ hybridization of tissues on microscope slide ... study of gene expression, in situ hybridization (ISH) ... can be used to validate and confirm results ...
... Array Analyst Software has been optimized for ... algorithms allow the software to quickly and ... each well of an ELISA plate or ... Analyst Software has been customized to incorporate ...
... products feature a dual strength adhesive system which ... use. The adhesives on either side of the ... adheres to the glass has an easy release ... coverslip, forms a stronger bond. This means that ...
Biology Products: