Navigation Links
Stem cells restore cognitive abilities impaired by brain cancer treatment
Date:7/13/2011

Irvine, Calif., July 13, 2011 Human neural stem cells are capable of helping people regain learning and memory abilities lost due to radiation treatment for brain tumors, a UC Irvine study suggests.

Research with rats found that stem cells transplanted two days after cranial irradiation restored cognitive function, as measured in one- and four-month assessments. In contrast, irradiated rats not treated with stem cells showed no cognitive improvement.

"Our findings provide solid evidence that such cells can be used to reverse radiation-induced damage of healthy tissue in the brain," said Charles Limoli, a UCI radiation oncology professor.

Study results appear in the July 15 issue of Cancer Research, a journal of the American Association for Cancer Research.

Radiotherapy for brain tumors is limited by how well the surrounding tissue tolerates it. Patients receiving radiation at effective levels suffer varying degrees of learning and memory loss that can adversely affect their quality of life.

"In almost every instance, people experience severe cognitive impairment that's progressive and debilitating," Limoli said. "Pediatric cancer patients can experience a drop of up to three IQ points per year."

For the UCI study, multipotent human neural stem cells were transplanted into the brains of rats that had undergone radiation treatment. They migrated throughout the hippocampus a region known for the growth of new neurons and developed into brain cells.

Researchers assessed the rats one month and four months after transplantation, noting enhanced learning and memory abilities at both intervals.

Additionally, they found that transplanting as few as 100,000 human neural stem cells was sufficient to improve cognition after cranial irradiation. Of cells surviving the process, about 15 percent turned into new neurons, while another 45 percent became astrocytes and oligodendrocytes cells that support cerebral neurons.

Most notably, Limoli said, he and his colleagues discovered that about 11 percent of the engrafted cells expressed a behaviorally induced marker of learning, indicating the functional integration of those cells into memory circuits in the hippocampus.

"This research suggests that stem cell therapies may one day be implemented in the clinic to provide relief to patients suffering from cognitive impairments incurred as a result of their cancer treatments," Limoli said. "While much work remains, a clinical trial analyzing the safety of such approaches may be possible within a few years, most likely with patients afflicted with glioblastoma multiforme, a particularly aggressive and deadly form of brain cancer."


'/>"/>

Contact: Tom Vasich
tmvasich@uci.edu
949-824-6455
University of California - Irvine
Source:Eurekalert

Related biology news :

1. Deeper insight in the activity of cortical cells
2. Sertoli cells show promise for therapeutics
3. Scientists discover how best to excite brain cells
4. Unnatural chemical allows Salk researchers to watch protein action in brain cells
5. Scientists devise way to sort brain cells for potential transplants
6. Researchers characterize biomechanics of ovarian cells according to phenotype at stages of cancer
7. New technique advances bioprinting of cells
8. Mutations can spur dangerous identity crisis in cells
9. Adult stem cells carry their own baggage: Epigenetics guides stem cell fate
10. Rogue blood cells may contribute to post-surgery organ damage
11. Johns Hopkins scientists expose cancer cells universal dark matter
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/7/2017)... Zimmer Biomet Holdings, Inc. (NYSE and SIX: ... at the LEERINK Partners 6th Annual Global Healthcare Conference ... February 15, 2017 at 10 a.m. Eastern Time. ... be accessed at http://wsw.com/webcast/leerink28/zbh .  The webcast will ... Biomet,s Investor Relations website at http://investor.zimmerbiomet.com . ...
(Date:2/2/2017)... , Feb. 2, 2017   TapImmune, ... clinical-stage immuno-oncology company specializing in the development of ... the treatment of cancer and metastatic disease, announced ... and GMP manufacturing of a second clinical lot ... targeting folate receptor alpha. The manufactured vaccine product ...
(Date:1/30/2017)... FRANCISCO , Jan. 30, 2017   Invitae ... the fastest growing genetic information companies, today announced that ... financial results and provide 2017 guidance on Monday, February ... conference call that day at 4:45 p.m. Eastern / ... Invitae,s management team will briefly review financial results, guidance, ...
Breaking Biology News(10 mins):
(Date:2/21/2017)... CA (PRWEB) , ... February 21, 2017 , ... ... the VTX-1 Liquid Biopsy System , a fully automated benchtop system for ... technology. The VTX-1 is being launched at the Molecular Medicine Tri Conference (Tri-Con) ...
(Date:2/21/2017)... CA (PRWEB) , ... February 21, 2017 , ... The ... prospects for their use, in multiple areas of medicine, due to their differentiating characteristics. ... division, and they have the ability to be induced to become tissue or organic-specific ...
(Date:2/21/2017)... (PRWEB) , ... February 21, 2017 , ... ... creating transformative design and manufacturing solutions for original equipment manufacturers (OEMs) , today ... 2017 marks Creation Technologies’ third consecutive year winning in its category of electronics ...
(Date:2/21/2017)... YORK , Feb. 21, 2017   Logicalis ... an international IT solutions and managed services provider ( ... – Service Desk for Epic. The new service will ... internal Epic resources by giving physicians, nurses and other ... specialists for tier-one support. This will allow hospital IT ...
Breaking Biology Technology: