Navigation Links
Stem cells reach standard for use in drug development

Drug development for a range of conditions could be improved with stem cell technology that helps doctors predict the safety and the effectiveness of potential treatments.

Medical Research Council scientists at the University of Edinburgh have been able to generate cells in the laboratory that reach the gold standard required by the pharmaceutical industry to test drug safety.

The researchers used stem cell technology to generate liver cells which help our bodies to process drugs.

They found that the cells were equally effective, reaching the same standard, as cells from human liver tissue currently used to assess drug safety.

These human cells used in drug testing are in short supply and vary considerably due to different donors. As a result they are not an ideal source for drug development.

The stem cell based technique developed in Edinburgh, addresses these issues by offering a renewable production of uniform liver cells in the laboratory.

Dr David Hay of the Medical Research Council (MRC) Centre for Regenerative Medicine at the University of Edinburgh, said: "Differing genetic information plays a key role in how patients' livers process drugs. We are now able to efficiently produce human liver cells in the laboratory from different people which model the functional differences in human genetics."

Researchers hope to generate liver cells, containing different DNA to reflect the genetic variations in metabolism found in the population that could be used to help identify differences in response among patients to certain drugs. The laboratory-generated liver cells could also be used to screen certain drugs that need close monitoring, to optimise patient treatment.

Scientists are working with Edinburgh BioQuarter, with a view to forming a spin-out company to commercialise the research.


Contact: Tara Womersley
University of Edinburgh

Page: 1

Related biology news :

1. How cells get a skeleton
2. First dual-action compound kills cancer cells, stops them from spreading
3. Down syndrome neurons grown from stem cells show signature problems
4. Keeping stem cells strong
5. MU researchers develop radioactive nanoparticles that target cancer cells
6. Insight into the dazzling impact of insulin in cells
7. The compound in the Mediterranean diet that makes cancer cells mortal
8. SUMO wrestling cells reveal new protective mechanism target for stroke
9. Herpes infections: Natural killer cells activate hematopoiesis
10. Cells must use their brakes moderately for effective speed control
11. Newly described type of immune cell and T cells share similar path to maturity
Post Your Comments:
(Date:4/26/2016)... April 27, 2016 Research ... Multi-modal Biometrics Market 2016-2020"  report to their offering.  ... The analysts forecast the global multimodal ... 15.49% during the period 2016-2020.  Multimodal ... sectors such as the healthcare, BFSI, transportation, automotive, ...
(Date:4/14/2016)... 14, 2016 BioCatch ™, ... today announced the appointment of Eyal Goldwerger ... Goldwerger,s leadership appointment comes at a time ... the deployment of its platform at several of the ... which discerns unique cognitive and physiological factors, is a ...
(Date:3/29/2016)... , March 29, 2016 LegacyXChange, ... LegacyXChange "LEGX" and SelectaDNA/CSI Protect are pleased to announce ... used in a variety of writing instruments, ensuring athletes ... originally created collectibles from athletes on LegacyXChange will be ... of the DNA. Bill Bollander , ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... 23, 2016 A person commits a crime, and ... to track the criminal down. An outbreak of ... Drug Administration (FDA) uses DNA evidence to track down the ... Sound far-fetched? It,s not. The FDA has increasingly used a ... of foodborne illnesses. Put as simply as possible, whole genome ...
(Date:6/23/2016)... , June 23, 2016  The Prostate Cancer Foundation (PCF) is ... treatments and faster cures for prostate cancer. Members of the Class of 2016 ... countries. Read More About the Class of 2016 PCF ... ... ...
(Date:6/23/2016)... ... June 23, 2016 , ... Supplyframe, the ... the Supplyframe Design Lab . Located in Pasadena, Calif., the Design Lab’s ... how hardware projects are designed, built and brought to market. , The Design ...
(Date:6/23/2016)... 2016 Apellis Pharmaceuticals, Inc. today announced ... of its complement C3 inhibitor, APL-2. The trials ... dose studies designed to assess the safety, tolerability, ... in healthy adult volunteers. Forty subjects ... single dose (ranging from 45 to 1,440mg) or ...
Breaking Biology Technology: