Navigation Links
Stem cells reach standard for use in drug development

Drug development for a range of conditions could be improved with stem cell technology that helps doctors predict the safety and the effectiveness of potential treatments.

Medical Research Council scientists at the University of Edinburgh have been able to generate cells in the laboratory that reach the gold standard required by the pharmaceutical industry to test drug safety.

The researchers used stem cell technology to generate liver cells which help our bodies to process drugs.

They found that the cells were equally effective, reaching the same standard, as cells from human liver tissue currently used to assess drug safety.

These human cells used in drug testing are in short supply and vary considerably due to different donors. As a result they are not an ideal source for drug development.

The stem cell based technique developed in Edinburgh, addresses these issues by offering a renewable production of uniform liver cells in the laboratory.

Dr David Hay of the Medical Research Council (MRC) Centre for Regenerative Medicine at the University of Edinburgh, said: "Differing genetic information plays a key role in how patients' livers process drugs. We are now able to efficiently produce human liver cells in the laboratory from different people which model the functional differences in human genetics."

Researchers hope to generate liver cells, containing different DNA to reflect the genetic variations in metabolism found in the population that could be used to help identify differences in response among patients to certain drugs. The laboratory-generated liver cells could also be used to screen certain drugs that need close monitoring, to optimise patient treatment.

Scientists are working with Edinburgh BioQuarter, with a view to forming a spin-out company to commercialise the research.


Contact: Tara Womersley
University of Edinburgh

Page: 1

Related biology news :

1. How cells get a skeleton
2. First dual-action compound kills cancer cells, stops them from spreading
3. Down syndrome neurons grown from stem cells show signature problems
4. Keeping stem cells strong
5. MU researchers develop radioactive nanoparticles that target cancer cells
6. Insight into the dazzling impact of insulin in cells
7. The compound in the Mediterranean diet that makes cancer cells mortal
8. SUMO wrestling cells reveal new protective mechanism target for stroke
9. Herpes infections: Natural killer cells activate hematopoiesis
10. Cells must use their brakes moderately for effective speed control
11. Newly described type of immune cell and T cells share similar path to maturity
Post Your Comments:
(Date:11/9/2015)... , Nov. 9, 2015  Synaptics Inc. (NASDAQ: ... today announced broader entry into the automotive market with ... match the pace of consumer electronics human interface innovation. ... are ideal for the automotive industry and will be ... Europe , Japan ...
(Date:10/29/2015)... Daon, a global leader in mobile biometric ... new version of its IdentityX Platform , IdentityX ... have already installed IdentityX v4.0 and are ... FIDO UAF certified server component as an option ... features. These customers include some of the largest and ...
(Date:10/27/2015)... , Oct. 27, 2015 In the present ... of concern for various industry verticals such as banking, ... to the growing demand for secure & simplified access ... ,sectors, such as hacking of bank accounts, misuse of ... equipment such as PC,s, laptops, and smartphones are expected ...
Breaking Biology News(10 mins):
(Date:11/24/2015)... , Nov. 24, 2015 /PRNewswire/ - Aeterna ... announced today that the remaining 11,000 post-share consolidation ... Purchase Warrants (the "Series B Warrants") subject to ... exercised on November 23, 2015, which will result ... After giving effect to the issuance of such ...
(Date:11/24/2015)... ... November 24, 2015 , ... ... are paramount. Insertion points for in-line sensors can represent a weak spot where ... InTrac 781/784 series of retractable sensor housings , which are designed to tolerate ...
(Date:11/24/2015)... , ... November 24, 2015 , ... ... OrthoAccel® Technologies, Inc., on being named to Deloitte's 2015 Technology Fast 500 list ... facility, OrthoAccel manufactures AcceleDent®, a FDA-cleared, Class II medical device that speeds up ...
(Date:11/24/2015)... , Nov. 24, 2015 Capricor Therapeutics, ... focused on the discovery, development and commercialization of first-in-class ... Chief Executive Officer, is scheduled to present at the ... at 10:50 a.m. EST, at The Lotte New York ... . . --> ...
Breaking Biology Technology: