Navigation Links
Stem cells offer cartilage repair hope for arthritis sufferers
Date:4/11/2008

Research being presented today (11 April) at the UK National Stem Cell Network Annual Science Meeting in Edinburgh could offer hope that bone stem cells may be harnessed to repair the damaged cartilage that is one of the main symptoms of osteoarthritis.

Scientists at Cardiff University have successfully identified stem cells within articular cartilage of adults, which although it cannot become any cell in the body like full stem cells, has the ability to derive into chondrocytes - the cells that make up the bodys cartilage in high enough numbers to make treatment a realistic possibility. The team have even been able to identify the cells in people over 75 years of age.

Osteoarthritis affects over 2M people in the UK and occurs when changes in the make up of the bodys cartilage causes joints to fail to work properly. At its worse it can cause the break up of cartilage, causing the ends of the bones in the joint to rub against each other. This results in severe pain and deformation of the joint. One current treatment to treat damaged cartilage due to trauma in younger patients is to harvest cartilage cells from neighbouring healthy cartilage and transplant them into the damaged area. Unfortunately, only a limited number of cells can be generated.

The research team, funded by the Arthritis Research Campaign and the Swiss AO Foundation, have identified a progenitor, or a partially derived stem cell in bovine cartilage that can be turned into can be turned into a chondrocyte in culture. Their breakthrough came in identifying a similar cell in human cartilage that was more like a stem cell with characteristics that they could be used to treat cartilage lesions due to trauma but also mark the onset of osteoarthritis

Lead researcher Professor Charlie Archer from the Cardiff School of Biosciences said: We have identified a cell which when grown in the lab can produce enough of a persons own cartilage that it could be effectively transplanted. There are limitations in trying to transplant a patients existing cartilage cells but by culturing it from a resident stem cell we believe we can overcome this limitation.

This research could have real benefits for arthritis sufferers and especially younger active patients with cartilage lesions that can progress to whole scale osteoarthritis.

Prof Archer commented: We have embarked on the next stage which is to conduct and animal trial which is a necessary pre-requisite to a clinical trial which we hope to start next year if the results are positive


'/>"/>

Contact: Matt Goode
ukpo@uknscn.org
01-793-413-299
Biotechnology and Biological Sciences Research Council
Source:Eurekalert

Related biology news :

1. Can micro-scaffolding help stem cells rebuild the brain after stroke?
2. Popcorn-ball design doubles efficiency of dye-sensitized solar cells
3. Computation to unravel how genes are regulated and shed light on how cells become different
4. Stem cells and cancer: cancer pathways that also control the adult stem cell population
5. Scientists uncover the potential to control adult stem cells
6. Scientists ask whether microscaffolding can help stem cells rebuild brain after stroke damage
7. New study shows that fetal cells to treat Parkinsons disease may not function long term
8. T-cadherin affects blood vessel growth in breast cancer, hormone from fat cells may play a role
9. Strengthening the tumor-fighting ability of T cells
10. A switch that controls whether cells pass point of no return
11. Protein protects embryonic stem cells versatility and self-renewal
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/14/2016)... , March 14, 2016 NXTD ) ... mobile commerce market, announces the airing of a new series ... the week of March 21 st .  The commercials will ... its popular Squawk on the Street show. --> ... the growing mobile commerce market, announces the airing of a ...
(Date:3/10/2016)... Pa. , March 10, 2016   Unisys Corporation ... Customs and Border Protection (CBP) is testing its biometric ... San Diego to help identify certain non-U.S. ... . The test, designed to help determine the efficiency ... environment, began in February and will run until May 2016. ...
(Date:3/3/2016)... -- FlexTech, a SEMI Strategic Association Partner, awarded five FLEXI ... Leadership in Education, and, in a category new this ... year of the FLEXI Awards and the winners join ... past years . Judging was done on a set ... by a panel of non-affiliated, independent, industry experts. ...
Breaking Biology News(10 mins):
(Date:5/3/2016)... ... May 03, 2016 , ... Leading CEOs from biotech, ... 31st and June 1st at The Four Seasons Hotel Boston. , The Boston ... sciences, offering exclusive access to key decision makers who influence deal making and ...
(Date:5/3/2016)... THE WOODLANDS, Texas , May 3, 2016 /PRNewswire/ ... board certified plastic surgeon in The Woodlands, ... technology that destroys 24 percent of treated fat cells ... men and woman. Close to 90 percent of Americans ... effective treatment options. Nonsurgical fat reduction procedures are a ...
(Date:5/2/2016)... ... ... StarNet Communications Corp, ( http://www.starnet.com/ ) a leading publisher of remote Linux ... to its flagship X-Win32 PC X server. The new modules enable X-Win32 to ... over encrypted SSH. , Traditionally, users of PC X servers deploy the XDMCP protocol ...
(Date:4/29/2016)... April 29, 2016 According ... Market Research "Separation Systems for Commercial Biotechnology Market ... and Forecast 2015 - 2023", the separation systems ... 10,665.5 Mn in 2014 and is projected to ... to 2023 to reach US$ 19,227.8 Mn in ...
Breaking Biology Technology: