Navigation Links
Stem cells may solve mystery of early pregnancy breast cancer protection
Date:9/16/2008

The answer to why an early pregnancy seems to protect against breast cancer could rest with a decrease in stem cells found after animals have given birth, said researchers at Baylor College of Medicine in a report that appears in the current issue of the journal Stem Cell.

Women who have children young, at least before the age of 30, reduce their risk of developing breast cancer, said Dr. Yi Li, a professor in the Lester and Sue Smith Breast Center at BCM. The most dramatic reduction in risk occurs in women who have their first children before the age of 24. However, the mechanism by which these early pregnancies provided protection has proved elusive.

The promise of such work is important.

"If we can figure out the mechanism behind this, we could develop a pill that we could offer young women in high school and college that could significantly reduce their risk of breast cancer," he said.

However, he said, there are many steps to be taken before he and his colleagues can determine how best to do that. Understanding why stem cells decrease in women who have their children young could prove an important advance.

In studies in mice, Li and his colleagues compared the numbers of mammary or breast stem cells (early cells that can differentiate into breast tissue) found in mice that had had babies at an age equivalent to the teens to mice that had never had babies.

Using proven scientific techniques, they found that the mice that had had early pregnancies had half the numbers of mammary cells found in the mice that had never had babies, Li said.

They found that 1 in approximately 2,500 mammary cells were stem cells in the "virgin" mice while 1 in 5,000 were stem cells in the mice that had given birth.

Why having fewer stems cells protects against breast cancer remains unproven, said Li.

"Stem cells are long-living cells. One theory is that they can thus accumulate more mutations and are probably the most susceptible to giving rise to breast cancer," said Li. Thus, the more stem cells an animal has, the more likely the animal is to developing breast cancer.

However, Li stressed that this is just a theory.

He also noted that the protective effect of pregnancy is seen across the lifetime. The effect is not immediate. He studied the effect in mice that were 10 months old the equivalent to 50 to 60 years old in humans.

"We saw that the stem cells are reduced," he said. "We know that breast cancer risk is reduced. This is an association. We have not proven that reducing the number of stem cells actually reduces the risk of breast cancer."

That is the next step he plans to take in his research.


'/>"/>

Contact: Kimberlee Norton
kknorton@bcm.edu
713-798-4710
Baylor College of Medicine
Source:Eurekalert

Related biology news :

1. ESF EURYI award winner aims to stop cancer cells reading their own DNA
2. Newly created cancer stem cells could aid breast cancer research
3. AIDS interferes with stem cells in the brain
4. Clemson scientists shed light on molecules in living cells
5. Social habits of cells may hold key to fighting diseases
6. UF scientists reveal how dietary restriction cleans cells
7. Human derived stem cells can repair rat hearts damaged by heart attack
8. Scientists identify embryonic stem cells by appearance alone
9. Cells united against cancer
10. Pittsburgh scientists identify human source of stem cells with potential to repair muscle
11. U of M begins nations first clinical trial using T-reg cells from cord blood in leukemia treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/2/2016)... , Feb. 2, 2016  Based on ... Frost & Sullivan recognizes US-based Intelligent Retinal Imaging ... & Sullivan Award for New Product Innovation. IRIS, ... North America , is poised ... rapidly growing diabetic retinopathy market. The IRIS technology ...
(Date:2/1/2016)... , Feb. 1, 2016  Wocket® smart wallet ( www.wocketwallet.com ) announces ... personality, Joey Fatone . Las Vegas , ... --> Las Vegas , where Joey appeared ... The new video ad was filmed at the Consumer Electronics Show ... the Wocket booth to meet and greet fans. ...
(Date:1/25/2016)... BELL, Pa. , Jan. 25, 2016   Unisys Corporation ... recognition system at John F. Kennedy (JFK) International Airport, ... Border Protection (CBP) identify imposters attempting to enter ... do not belong to them. pilot testing of ... out initially at three terminals at JFK during January 2016. ...
Breaking Biology News(10 mins):
(Date:2/11/2016)... (PRWEB) , ... February 11, 2016 , ... ... of its new stem cell treatment clinic in Quito, Ecuador. The new facility ... and trauma applications to patients from around the world. , The new ...
(Date:2/10/2016)... NX Prenatal Inc., a US based ... for early warning of adverse pregnancy outcomes, announced ... by Dr. Thomas McElrath of Brigham ... Medicine,s (SMFM) annual meeting held in ... The presentation reported initial positive top-line results regarding ...
(Date:2/10/2016)...  Allergan plc (NYSE: AGN ) a leading ... , Allergan,s CEO and President, will be featured as ... the RBC Capital Markets Healthcare Conference on Tuesday, February ... York Palace Hotel in New York, NY ... can be accessed on Allergan,s Investor Relations web site ...
(Date:2/10/2016)... ... 2016 , ... LATHAM, NEW YORK... Marktech Optoelectronics will feature their ... in San Francisco’s Moscone Center from February 16-18, 2016, and at the healthcare-focused BiOS ... InGaAs PIN diode standard packages feature a TO-46 metal can with active areas of ...
Breaking Biology Technology: