Navigation Links
Stem cells may solve mystery of early pregnancy breast cancer protection
Date:9/16/2008

The answer to why an early pregnancy seems to protect against breast cancer could rest with a decrease in stem cells found after animals have given birth, said researchers at Baylor College of Medicine in a report that appears in the current issue of the journal Stem Cell.

Women who have children young, at least before the age of 30, reduce their risk of developing breast cancer, said Dr. Yi Li, a professor in the Lester and Sue Smith Breast Center at BCM. The most dramatic reduction in risk occurs in women who have their first children before the age of 24. However, the mechanism by which these early pregnancies provided protection has proved elusive.

The promise of such work is important.

"If we can figure out the mechanism behind this, we could develop a pill that we could offer young women in high school and college that could significantly reduce their risk of breast cancer," he said.

However, he said, there are many steps to be taken before he and his colleagues can determine how best to do that. Understanding why stem cells decrease in women who have their children young could prove an important advance.

In studies in mice, Li and his colleagues compared the numbers of mammary or breast stem cells (early cells that can differentiate into breast tissue) found in mice that had had babies at an age equivalent to the teens to mice that had never had babies.

Using proven scientific techniques, they found that the mice that had had early pregnancies had half the numbers of mammary cells found in the mice that had never had babies, Li said.

They found that 1 in approximately 2,500 mammary cells were stem cells in the "virgin" mice while 1 in 5,000 were stem cells in the mice that had given birth.

Why having fewer stems cells protects against breast cancer remains unproven, said Li.

"Stem cells are long-living cells. One theory is that they can thus accumulate more mutations and are probably the most susceptible to giving rise to breast cancer," said Li. Thus, the more stem cells an animal has, the more likely the animal is to developing breast cancer.

However, Li stressed that this is just a theory.

He also noted that the protective effect of pregnancy is seen across the lifetime. The effect is not immediate. He studied the effect in mice that were 10 months old the equivalent to 50 to 60 years old in humans.

"We saw that the stem cells are reduced," he said. "We know that breast cancer risk is reduced. This is an association. We have not proven that reducing the number of stem cells actually reduces the risk of breast cancer."

That is the next step he plans to take in his research.


'/>"/>

Contact: Kimberlee Norton
kknorton@bcm.edu
713-798-4710
Baylor College of Medicine
Source:Eurekalert

Related biology news :

1. ESF EURYI award winner aims to stop cancer cells reading their own DNA
2. Newly created cancer stem cells could aid breast cancer research
3. AIDS interferes with stem cells in the brain
4. Clemson scientists shed light on molecules in living cells
5. Social habits of cells may hold key to fighting diseases
6. UF scientists reveal how dietary restriction cleans cells
7. Human derived stem cells can repair rat hearts damaged by heart attack
8. Scientists identify embryonic stem cells by appearance alone
9. Cells united against cancer
10. Pittsburgh scientists identify human source of stem cells with potential to repair muscle
11. U of M begins nations first clinical trial using T-reg cells from cord blood in leukemia treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/10/2016)... , March 10, 2016 ... market research report "Identity and Access Management Market by ... Compliance, and Governance), by Organization Size, by Deployment, by ... published by MarketsandMarkets, The market is estimated to grow ... Billion by 2020, at a Compound Annual Growth Rate ...
(Date:3/9/2016)... , March 9, 2016  Crossmatch ® , ... enrollment solutions, today announced the addition of smart ... Altus multi-factor authentication platform. New contextual and ... to step-up security where it,s needed most — ... Washington, DC . --> ...
(Date:3/3/2016)... DE SOTO, Kansas , March 3, ... Plus® to offer Oncimmune,s Early CDT®-Lung, a blood ... detection of lung cancer Early CDT®-Lung test ... individuals. --> Early CDT®-Lung test to its ... --> Oncimmune, a leader in early cancer detection, ...
Breaking Biology News(10 mins):
(Date:4/29/2016)... ... April 29, 2016 , ... Proove ... excited to announce the launch of the Proove Health Foundation . The ... education to promote the use of personalized medicine for tackling the nation’s most-pressing ...
(Date:4/29/2016)... KY and San Diego, CA (PRWEB) , ... April 29, 2016 ... ... National Stem Cell Foundation (NSCF) to support the development of a patient-specific stem cell ... Dr. Andrés Bratt-Leal in the lab of Dr. Jeanne Loring at The Scripps Research ...
(Date:4/28/2016)... 2016 Q BioMed Inc. ... CEO  was featured in an article he wrote ... Fear To Tread: http://www.lifescienceleader.com/doc/accelerators-enter-when-vcs-fear-to-tread-0001 ... is an essential business journal for life science ... to Big Pharmas. Their content is designed to ...
(Date:4/28/2016)... ... 2016 , ... Morris Midwest ( http://www.morrismidwest.com ), a division ... its Maple Grove, Minnesota technical center, May 11-12. The event will feature ... 20 leading suppliers of tooling, accessories, software and other related technology will participate ...
Breaking Biology Technology: