Navigation Links
Stem cells may prevent post-injury arthritis
Date:8/10/2012

ategory, too. They bounce back quickly and heal well naturally after a fracture, while other people eventually form cases of arthritis at the fractured joint, said Guilak, who is a professor of orthopaedic surgery and biomedical engineering.

"The ability of the superhealer mice to have superior healing after a fracture may go beyond the properties of their stem cells and be some beneficial factor, like a growth factor, that we don't know about yet," Guilak said.

The delivery of 10,000 typical or superhealer stem cells to the joint prevented the mice from developing PTA, unlike a control group that received only saline.

Diekman said the team looked at markers of inflammation and saw that the stem cells affected the inflammatory environment of the joint after fracture.

"The stem cells changed the levels of certain immune factors, called cytokines, and altered the bone healing response," said Diekman, who is also with the Duke Department of Biomedical Engineering.

Guilak said that very few studies have purified stem cells to the degree they were purified for this study. They used mesenchymal stem cells, which are bone marrow cells not destined to become part of blood.

Diekman said that one of the challenges in the field is isolating and developing a system for sorting the specific cells they wanted, the mesenchymal stem cells, which form a very rare cell type in the bone marrow.

"We found that by placing the stem cells into low-oxygen conditions, they would grow more rapidly in culture so that we could deliver enough of them to make a difference therapeutically," Diekman said.


'/>"/>
Contact: Mary Jane Gore
mary.gore@duke.edu
919-660-1309
Duke University Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Anti-aging elixir for solar cells
2. Embryonic blood vessels that make blood stem cells can also make beating heart muscles
3. Long-distance distress signal from periphery of injured nerve cells begins with locally made protein
4. Cell receptor has proclivity for T helper 9 cells, airway inflammation
5. Key function of protein discovered for obtaining blood stem cells as source for transplants
6. Breakthrough technology focuses in on disease traits of single cells
7. New genomic sequencing method enables smarter anaysis of individual cells
8. Blood vessel forming potential of stem cells from human placenta and umbilical cord blood
9. Researchers identify mechanisms that allow embryonic stem cells to become any cell in the human body
10. Nanoscale scaffolds and stem cells show promise in cartilage repair
11. Force of nature: Defining the mechanical mechanisms in living cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... PULLMAN, Wash. - Washington State University researchers have developed ... sediment to power waste cleanup in rural areas. ... lead to an inexpensive and quick way to clean ... treatment plants while reducing pollution. , Professor Haluk ... College of Engineering and Architecture discuss the system in ...
(Date:9/18/2014)... Boulder, Colo., USA Miranda, a small, icy moon ... and enigmatic bodies in the solar system. Despite its ... episode of intense resurfacing that resulted in the formation ... -- polygonal-shaped regions called coronae. , These coronae ... is at least 200 km across. Arden corona, the ...
(Date:9/18/2014)... McGill University and the Quebec government have discovered ... Canadian Journal of Fisheries and Aquatic Sciences . ... cleansers, or industrial cleansers, to which they are ... size and buoyancy, they may readily pass through ... contaminant in the world,s oceans, but have only ...
Breaking Biology News(10 mins):Researchers develop unique waste cleanup for rural areas 2Miranda: An icy moon deformed by tidal heating 2Miranda: An icy moon deformed by tidal heating 3Miranda: An icy moon deformed by tidal heating 4Miranda: An icy moon deformed by tidal heating 5Miranda: An icy moon deformed by tidal heating 6Miranda: An icy moon deformed by tidal heating 7Microplastic pollution discovered in St. Lawrence River sediments 2
... announce the publication of an up-to-date, concise resource for ... Small Animal Regional Anesthesia and Analgesia provides practical, clinically ... organized logically by body system. , The first ... resource, Small Animal Regional Anesthesia and Analgesia is equally ...
... with fruit flies, Johns Hopkins scientists have decoded the ... know when and where to branch so that they ... proteins, mammalian counterparts are known to have signaling roles ... progression, suggesting broad implications for human disease research. A ...
... In 2004 a very popular study aimed to address ... or approaches. According to the study by Robert Socolow and ... carbon (1 GtC) emissions per year after 50 years. The ... carbon dioxide emissions relative to what would happen if things ...
Cached Biology News:Molecular '2-way radio' directs nerve cell branching and connectivity 2Molecular '2-way radio' directs nerve cell branching and connectivity 3Preventing climate change: The size of the energy challenge 2
(Date:9/20/2014)... MediVet America and NanoFiber Veterinary combined ... the specialized Wolvega Horse Clinic. , Due to a ... ruptured 90% and her deep digital flexor tendon 50%. ... for a horse. , The clinic has performed numerous ... This revolutionary regenerative option for ruptured tendons has only ...
(Date:9/19/2014)... rarely simple. From crop yields to disease risks, the ... considered "complex traits." Just as for heightthe textbook example ... human disease are shaped by multiple genetic and environmental ... To track down such genes, geneticists typically mate two ... mouse and a small mouseand then study their descendents, ...
(Date:9/19/2014)... than electricity, to move data would consume much ... growing concern as chips, transistor counts rise. , ... light emitters, modulators, and detectors emitters ... source for optical chips is molybdenum disulfide (MoS2), ... a single, atom-thick layer. Other experimental on-chip light ...
(Date:9/19/2014)... 2014  An entire month is dedicated to one ... Charcot-Marie-Tooth disease (CMT) – a debilitating neuromuscular disease affecting ... atrophy, weakness, and foot and hand deformities. CMT affects ... CMT is a progressive disease, and over time patients ... devices such as leg braces, wheelchairs and scooters to ...
Breaking Biology Technology:World’s first tendon replacement using Nanofiber and activated MediVet Stem Cell Fraction 2World’s first tendon replacement using Nanofiber and activated MediVet Stem Cell Fraction 3Want to link genes to complex traits? Start with more diversity 2Toward optical chips 2Toward optical chips 3September is Charcot-Marie-Tooth (CMT) Awareness Month - Scheduled events, activities and important partnerships announced throughout the month! 2
... 2011 Leading events organiser UBM Live and ... announced details of the anticipated content and new developments taking ... International pharmaceutical event, being held from 18-20 April, 2011 at ... of events surrounding CPhI Japan includes P-MEC Japan, which covers ...
... PARK, Md., March 8, 2011 -- The Maryland Technology ... semifinalists for the University of Maryland $75K Business ... competition has served as a launch pad for ... among 71 entries in the categories of high-technology and ...
... Surgical Technology today announces the market launch of their ... in extremities and pelvis. The new ... of Foot and Ankle Surgeons (ACFAS) convention in Fort ... Legato™, will be included. Legato is a resorbable, collagen-based ...
Cached Biology Technology:UBM Announces Content for 10th Annual Japanese Pharma & Bio Events 2UBM Announces Content for 10th Annual Japanese Pharma & Bio Events 3UBM Announces Content for 10th Annual Japanese Pharma & Bio Events 4Mtech Announces Semifinalists for University of Maryland $75K Business Plan Competition 2Mtech Announces Semifinalists for University of Maryland $75K Business Plan Competition 3Mtech Announces Semifinalists for University of Maryland $75K Business Plan Competition 4Mtech Announces Semifinalists for University of Maryland $75K Business Plan Competition 5Mtech Announces Semifinalists for University of Maryland $75K Business Plan Competition 6Pioneer® Surgical Technology, Inc. Enters the Biologics Extremities and Pelvis Market 2
... Staining Kit is uniquely formulated to ... minimal protein modification for optimal mass ... associated with traditional silver stains are ... the reagents used do not modify ...
...
Schneider's Drosophila Medium is formulated for the expression of heterologous proteins in Drosophila S2 cells....
D.R. Harper (1993) • Includes: essential information on taxonomy, culture and safe handling of viruses, immunology, monoclonal antibodies, antivirals and vaccines....
Biology Products: