Navigation Links
Stem cells may prevent post-injury arthritis
Date:8/10/2012

ategory, too. They bounce back quickly and heal well naturally after a fracture, while other people eventually form cases of arthritis at the fractured joint, said Guilak, who is a professor of orthopaedic surgery and biomedical engineering.

"The ability of the superhealer mice to have superior healing after a fracture may go beyond the properties of their stem cells and be some beneficial factor, like a growth factor, that we don't know about yet," Guilak said.

The delivery of 10,000 typical or superhealer stem cells to the joint prevented the mice from developing PTA, unlike a control group that received only saline.

Diekman said the team looked at markers of inflammation and saw that the stem cells affected the inflammatory environment of the joint after fracture.

"The stem cells changed the levels of certain immune factors, called cytokines, and altered the bone healing response," said Diekman, who is also with the Duke Department of Biomedical Engineering.

Guilak said that very few studies have purified stem cells to the degree they were purified for this study. They used mesenchymal stem cells, which are bone marrow cells not destined to become part of blood.

Diekman said that one of the challenges in the field is isolating and developing a system for sorting the specific cells they wanted, the mesenchymal stem cells, which form a very rare cell type in the bone marrow.

"We found that by placing the stem cells into low-oxygen conditions, they would grow more rapidly in culture so that we could deliver enough of them to make a difference therapeutically," Diekman said.


'/>"/>
Contact: Mary Jane Gore
mary.gore@duke.edu
919-660-1309
Duke University Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Anti-aging elixir for solar cells
2. Embryonic blood vessels that make blood stem cells can also make beating heart muscles
3. Long-distance distress signal from periphery of injured nerve cells begins with locally made protein
4. Cell receptor has proclivity for T helper 9 cells, airway inflammation
5. Key function of protein discovered for obtaining blood stem cells as source for transplants
6. Breakthrough technology focuses in on disease traits of single cells
7. New genomic sequencing method enables smarter anaysis of individual cells
8. Blood vessel forming potential of stem cells from human placenta and umbilical cord blood
9. Researchers identify mechanisms that allow embryonic stem cells to become any cell in the human body
10. Nanoscale scaffolds and stem cells show promise in cartilage repair
11. Force of nature: Defining the mechanical mechanisms in living cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/16/2014)... 2014) – Post-menopausal women experienced improvements in vaginal ... or genital bleeding, after 12 weeks of daily ... soy germ-based nutritional supplement previously shown to help ... peer-reviewed pilot study reported in a poster at ... meeting. , "These data documented improved vaginal ...
(Date:10/15/2014)... , Oct. 15, 2014 Sandata Technologies, ... home and community-based care, today announced it released ... Sandata,s Santrax® Electronic Visit Verification™ Solution (EVV™)  for ... a home health company founded in 1996 and ... . The study details the ...
(Date:10/15/2014)... biophysics textbook and it describes how life functions and ... into biological systems and provides an understanding of the ... how our genes make proteins that control the dynamics ... an organism. It quantifies the principles of life and ... on both large and small scales. The book is ...
Breaking Biology News(10 mins):S-equol supplements associated with improved measures of reproductive health in postmenopausal women 2Sandata Announces Case Study with Quality Care Services, Inc. 2New book about life as seen from physics 2
... camera traps, wildlife researchers including doctoral candidate Jennifer McCarthy ... of Massachusetts Amherst recently captured photographs of one of ... They say it may now be found only in ... Their pictures and other observations are reported in ...
... professionals from 32 countries throughout Latin America and the ... of the International Osteoporosis Foundation,s (IOF) 1st Latin America ... four-day meeting, which extends to May 27 at the ... and the latest advances in the management of osteoporosis ...
... May 24, 2012 (BRONX, NY) "It,s in ... about factors that allow centenarians to reach age 100 and ... variations that offer a physiological advantage such as high levels ... College of Medicine and Ferkauf Graduate School of ...
Cached Biology News:UMass Amherst wildlife researcher photographs rare Sumatran rabbit 2UMass Amherst wildlife researcher photographs rare Sumatran rabbit 3Major osteoporosis meeting opens in São Paulo 2'Personality genes' may help account for longevity 2
(Date:10/20/2014)... MENLO PARK, Calif. , Oct. 20, 2014 ... announced today that the Company has signed a ... Institute of Regenerative Medicine (CIRM), effective October 1, ... of Clinical Development payments and the release of ... $14.3 million CIRM grant award for clinical development ...
(Date:10/20/2014)... Oct. 20, 2014 PureTech , a ... big healthcare problems, announced today the closing of ... participation from Invesco Perpetual, a $120 Billion group ... drive PureTech,s existing pipeline forward and to advance ... the scientific creativity to really go for the ...
(Date:10/19/2014)... The Latin American hardware encryption display ... America with analysis and forecast of revenue. This market ... expected to reach $2,366.8 million by 2018, at a ... through the TOC of the Latin American hardware encryption ... analysis provided. It also provides a glimpse of the ...
(Date:10/19/2014)... 19, 2014 The Asian Automatic patient ... with analysis and forecast of revenue. The Automatic patient ... around $463.9 million by 2018, at a developing CAGR ... the TOC of the Asian Automatic patient billing market, ... This also provides a glimpse of the segmentation of ...
Breaking Biology Technology:Asterias Biotherapeutics Announces Notice of Grant Award with CIRM for Phase 1/2a Clinical Trial of AST-OPC1 in Complete Cervical Spinal Cord Injury 2Asterias Biotherapeutics Announces Notice of Grant Award with CIRM for Phase 1/2a Clinical Trial of AST-OPC1 in Complete Cervical Spinal Cord Injury 3Asterias Biotherapeutics Announces Notice of Grant Award with CIRM for Phase 1/2a Clinical Trial of AST-OPC1 in Complete Cervical Spinal Cord Injury 4PureTech Announces Expansion with Oversubscribed $55M Funding Round 2PureTech Announces Expansion with Oversubscribed $55M Funding Round 3PureTech Announces Expansion with Oversubscribed $55M Funding Round 4PureTech Announces Expansion with Oversubscribed $55M Funding Round 5PureTech Announces Expansion with Oversubscribed $55M Funding Round 6The Latin American hardware encryption display market is expected to reach $2,366.8 million by 2018 - New Report by MicroMarket Monitor 2The Latin American hardware encryption display market is expected to reach $2,366.8 million by 2018 - New Report by MicroMarket Monitor 3The Asian Automatic patient billing market is estimated to grow to around $463.9 million by 2018 - New Report by MicroMarket Monitor 2The Asian Automatic patient billing market is estimated to grow to around $463.9 million by 2018 - New Report by MicroMarket Monitor 3
... Group,(Debiopharm), a global independent biopharmaceutical development specialist,in ... that it,received current Good Manufacturing Practices (cGMP) ... biochemical quality control work,conducted at its laboratory ... of the Lausanne site was extended for ...
... SGX Pharmaceuticals, Inc.,(Nasdaq: SGXP ) today provided ... Novartis focused on the development and commercialization of,BCR-ABL ... and drug resistant,Chronic Myelogenous Leukemia (CML). Under ... number of,potential drug candidates, with the anticipated timeline ...
... MichBio, the association for,Michigan,s life sciences industry, announced the ... Lansing. Guided tours will be available to Expo ... of the Expo, October 16. Attendees must register for ... and maps to the,locations. Visitors will transport themselves to ...
Cached Biology Technology:Debiopharm Receives cGMP Certification for Quality Control of its Drug Products 2SGX Provides Update on BCR-ABL Collaboration 2SGX Provides Update on BCR-ABL Collaboration 3MichBio Announces Expo Tours; Extends Deadline for Innovator Showcase Applications 2
The F40 pump maintenance kit is used to service one F40 pump of a BioLogic DuoFlow workstation. It includes 2 piston seals, 4 check valves, seal removal tool, and 2 O-rings....
...
...
...
Biology Products: