Navigation Links
Stem cells in neurodegeneration: challenges and future neurotherapeutic prospects
Date:6/16/2014

Researchers at the University of Florida, USA, led by Dr. K. Wang have demonstrated that inhibition of Rho-associated kinase (ROCK) and subsequent cofilin dephosphorylation is mediating neurite outgrowth in PC12 cells. The lack of axonal regeneration in adult central nervous system (CNS) is one of the main cause of neurodegenerative disorders. Thus ROCK inhibition mediated neurite outgrowth is clinically relevant to treat CNS diseases such as Alzheimer's disease, spinal cord injury, traumatic brain injury and stroke (Zhang et al., 2006).

In a follow up study by Prof. W.S. Poon and Dr. P.K. Lam's team from The Chinese University of Hong Kong and Dr. Wang's group, they successfully transplanted mesenchymal stem cells (MSCs) to the brain by topical application in an experimental traumatic brain injury model. Indeed, MSCs delivered to the brain surface were able to migrate to the damaged TBI site. This novel approach makes up for the numerous drawbacks associated with systemic infusion. Moreover, MSCs are capable of neurorepair and neuroprotection, which make their successful transplantation even more significant (Lam et al., 2013).

A combination of these different results can be therapeutically valuable to treat neurodegenerative disorders. As illustrated in this mini-review published in Neural Regeneration Research, Vol. 9, No.: "other and our laboratories are increasingly focusing on combining the use of pharmacological agents (such as Rho-associated kinase (ROCK) inhibitors or other growth factors (such as BDNF) and stem cell treatment to enhance the survivability and/or differentiation capacity of transplanted stem cells in neurotrauma or other neurodegeneration animal models". Nonetheless, the author highlighted the fact that "we still haven't fully grasped the concept of neurogenesis and how it really works", although it is primordial if we want to conceive new therapeutic techniques for neurodegenerative diseases and injuries.


'/>"/>
Contact: Meng Zhao
eic@nrren.org
86-138-049-98773
Neural Regeneration Research
Source:Eurekalert  

Related biology news :

1. Proliferation cues natural killer cells for job change
2. Guidelines needed for creating germ cells in vitro, Cornell, JAX scientists state
3. Coral, human cells linked in death
4. New class of nanoparticle brings cheaper, lighter solar cells outdoors
5. Specific protein may help beta cells survive in type 1 diabetes
6. Tangled path of Alzheimers-linked brain cells mapped in mice
7. Scientists reveal details of calcium safety-valve in cells
8. Stem cells hold keys to bodys plan
9. Stem cells found to play restorative role when affecting brain signaling process
10. First demonstration in human cells of chromosomal translocations that cause certain cancer
11. MU scientists successfully transplant, grow stem cells in pigs
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Stem cells in neurodegeneration: challenges and future neurotherapeutic prospects
(Date:5/12/2016)... May 12, 2016 WearablesResearch.com , a ... the overview results from the Q1 wave of its ... wave was consumers, receptivity to a program where they ... a health insurance company. "We were surprised ... says Michael LaColla , CEO of Troubadour Research, ...
(Date:5/3/2016)... 2016  Neurotechnology, a provider of high-precision biometric ... Biometric Identification System (ABIS) , a complete system ... ABIS can process multiple complex biometric transactions with ... fingerprint, face or iris biometrics. It leverages the ... MegaMatcher Accelerator , which have been used ...
(Date:4/28/2016)... GOTHENBURG, Sweden , April 28, 2016 ... 1,491.2 M (139.9), up 966% compared with the first quarter of ... Operating profit totaled SEK 589.1 M (loss: 18.8) and the operating ... SEK 7.12 (loss: 0.32) Cash flow from operations was ... , The 2016 revenue guidance is unchanged, SEK 7,000-8,500 M. ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... 2016  Sequenom, Inc. (NASDAQ: SQNM ), ... through the development of innovative products and services, announced ... United States denied its petition to review ... Sequenom,s U.S. Patent No. 6,258,540 (",540 Patent") are not ... the Supreme Court,s Mayo Collaborative Services v. Prometheus Laboratories ...
(Date:6/27/2016)... NC (PRWEB) , ... June 27, 2016 , ... ... mission to bring innovative medical technologies, services and solutions to the healthcare market. ... and implementation of various distribution, manufacturing, sales and marketing strategies that are necessary ...
(Date:6/27/2016)... 27, 2016   Ginkgo Bioworks , a leading ... was today awarded as one of the World ... world,s most innovative companies. Ginkgo Bioworks is engineering ... real world in the nutrition, health and consumer ... with customers including Fortune 500 companies to design ...
(Date:6/24/2016)... ... , ... While the majority of commercial spectrophotometers and fluorometers use the z-dimension ... are higher end machines that use the more unconventional z-dimension of 20mm. Z-dimension ... bottom of the cuvette holder. , FireflySci has developed several Agilent flow cell ...
Breaking Biology Technology: