Navigation Links
Stem cells develop best in 3-D
Date:11/21/2012

Scientists from The Danish Stem Cell Center (DanStem) at the University of Copenhagen are contributing important knowledge about how stem cells develop best into insulin-producing cells. In the long term this new knowledge can improve diabetes treatment with cell therapy. The results have just been published in the scientific journal Cell Reports.

Stem cells are responsible for tissue growth and tissue repair after injury. Therefore, the discovery that these vital cells grow better in a three-dimensional environment is important for the future treatment of disease with stem cell therapy.

"We can see that the quality of the cells produced two-dimensionally is not good enough. By putting the cells in a three-dimensional environment and giving them the proper growth conditions, we get much better results. Therefore we are developing a three-dimensional culture medium in gelatine in the laboratory to mimic the one inside an embryo," says Professor Anne Grapin-Botton from DanStem at the University of Copenhagen, who produced the results together with colleagues from Switzerland and Belgium.

The international research team hopes that the new knowledge about three-dimensional cell growth environments can make a significant contribution to the development of cell therapies for treating diabetes. In the long term this knowledge can also be used to develop stem cell treatments for chronic diseases in internal organs such as the liver or lungs. Like the pancreas, these organs are developed from stem cells in 3D.

From stem cells to specialised cells

The research team has investigated how the three-dimensional organisation of tissue in the early embryonic stage influences development from stem cells to more specialised cells.

"We can see that the pancreas looks like a beautiful little tree with branches. Stem cells along the branches need this structure to be able to create insulin-producing cells in the embryo. Our research suggests that in the laboratory beta cells can develop better from stem cells in 3D than if we try to get them to develop flat in a Petri dish," explains Professor Grapin-Botton.

"Attempts to develop functional beta cells in 2D have unfortunately most often resulted in poorly functioning cells. Our results from developing cells in 3D have yielded promising results and are therefore an important step on the way to developing cell therapies for treating diabetes."

The research is supported by the Novo Nordisk Foundation, Swiss National Research Foundation, and the National Institute of Health (NIH), USA.

The results from the paper "Planar Cell Polarity Controls Pancreatic Beta Cell Differentiation and Glucose Homeostasis" have just been published in the scientific journal Cell Reports.

Facts on beta cells

Insulin-producing cells are also called beta cells. They are found in groups in the pancreas in the Islets of Langerhans. These cells have been destroyed in people with type 1 diabetes, who cannot therefore produce insulin. Insulin is the hormone that keeps our blood glucose level stable. Today most people with diabetes take insulin doses several times a day by hypodermic needle or insulin pump. In a few extreme cases surgeons transplant beta cells from another person to try to re-establish stable blood glucose, but this treatment strategy has severe limitations due to immunological complications and scarcity of donor tissue.


'/>"/>

Contact: Anne Grapin-Botton
anne.grapin-botton@sund.ku.dk
(45) 29-63-43-98
University of Copenhagen
Source:Eurekalert

Related biology news :

1. A step forward in regenerating and repairing damaged nerve cells
2. Skin cells reveal DNAs genetic mosaic
3. Wandering minds associated with aging cells
4. A class of RNA molecules protects germ cells from damage, Penn vet researchers show
5. Neurons made from stem cells drive brain activity after transplantation in laboratory model
6. These bots were made for walking: Cells power biological machines
7. Appetite suppressant for scavenger cells
8. How cells in the nose detect odors
9. NIH awards Penn scientists $10 million over 5 years for innovative research on single cells
10. New type of bacterial protection found within cells
11. Study sheds light on genetic clock in embryonic cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/20/2016)... , May 20, 2016  VoiceIt is ... partnership with VoicePass. By working together, ... experience.  Because VoiceIt and VoicePass take slightly different ... engines increases both security and usability. ... excitement about this new partnership. "This ...
(Date:5/12/2016)... 2016 WearablesResearch.com , a brand of ... results from the Q1 wave of its quarterly wearables ... consumers, receptivity to a program where they would receive ... insurance company. "We were surprised to see ... Michael LaColla , CEO of Troubadour Research, "primarily because ...
(Date:5/3/2016)...  Neurotechnology, a provider of high-precision biometric identification ... Identification System (ABIS) , a complete system for ... can process multiple complex biometric transactions with high ... face or iris biometrics. It leverages the core ... MegaMatcher Accelerator , which have been used in ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... , June 23, 2016  Blueprint Bio, a company ... to the medical community, has closed its Series A ... Nunez . "We have received a commitment ... capital we need to meet our current goals," stated ... us the runway to complete validation on the current ...
(Date:6/23/2016)... Francisco, CA (PRWEB) , ... June 23, 2016 ... ... (EDC) software, is exhibiting at the Pennsylvania Convention Center and will showcase its ... Annual conference. ClinCapture will also be presenting a scientific poster on Disrupting Clinical ...
(Date:6/23/2016)... , June 22, 2016  Amgen (NASDAQ: ... of the QB3@953 life sciences incubator to ... health. The shared laboratory space at QB3@953 was created ... a key obstacle for many early stage organizations - ... of the sponsorship, Amgen launched two "Amgen Golden Ticket" ...
(Date:6/22/2016)... 22, 2016 Research and Markets has announced ... report to their offering. ... from $29.3 billion in 2013. The market is expected to grow ... 2015 to 2020, increasing from $50.6 billion in 2015 to $96.6 ... during the forecast period (2015 to 2020) are discussed. As well, ...
Breaking Biology Technology: