Navigation Links
Stem cells battle for space
Date:12/4/2009

The body is a battle zone. Cells constantly compete with one another for space and dominance. Though the manner in which some cells win this competition is well known to be the survival of the fittest, how stem cells duke it out for space and survival is not as clear. A study on fruit flies published in the October 2 issue of Science by Johns Hopkins researchers describes how stem cells win this battle by literally sticking around.

"Our work exemplifies how one signal coordinately maintains two types of stem cells in a single niche, or microenvironment," says Erika Matunis, Ph.D., associate professor of cell biology at the Johns Hopkins School of Medicine. "What we found may emerge as common themes of mammalian stem cell niches as they become better characterized."

To tackle the stem cell competition quandary, the team looked at fruit fly testes where two different stem cells exist: germline stem cells which give rise to sperm, and somatic stem cells which develop into non-reproductive cell types.

Using genetics, the researchers grew flies lacking the SOCS protein, which controls other molecules that promote stem cell growth. SOCS normally ensures that the right numbers of stem cells are present in the stem cell niche, a region at the far end of the fly testis where new cells are born. In a normal testis, the germline stem cells are surrounded by somatic stem cells at a ratio of about one germline stem cell for every two somatic stem cells.

The researchers isolated testes from flies lacking SOCS and, under a microscope, counted the number of germline stem cells and somatic stem cells. They found that nearly half of the germline stem cells were gone and the somatic stem cells appeared to be occupying that space.

"The somatic stem cells almost look like they've invaded the niche area," says Melanie Issigonis, a graduate student in the Biochemistry, Cellular, and Molecular Biology graduate program at Johns Ho
'/>"/>

Contact: Audrey Huang
audrey@jhmi.edu
410-614-5105
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2

Related biology news :

1. ESF EURYI award winner aims to stop cancer cells reading their own DNA
2. Newly created cancer stem cells could aid breast cancer research
3. AIDS interferes with stem cells in the brain
4. Clemson scientists shed light on molecules in living cells
5. Social habits of cells may hold key to fighting diseases
6. UF scientists reveal how dietary restriction cleans cells
7. Human derived stem cells can repair rat hearts damaged by heart attack
8. Scientists identify embryonic stem cells by appearance alone
9. Cells united against cancer
10. Pittsburgh scientists identify human source of stem cells with potential to repair muscle
11. U of M begins nations first clinical trial using T-reg cells from cord blood in leukemia treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/17/2014)... from the Copenhagen Centre for Social Evolution and Yale ... that birth weight and -length can partially predict the ... as autism and schizophrenia later in life. The study ... subsequent hospital diagnoses for up to 30 years, and ... study is published today in the Proceedings of ...
(Date:9/17/2014)... Biomedical Research Institute (ICO-IDIBELL), led by David Garcia-Mollev ... accompanying cells in colorectal tumors. Analysis of these ... predict the evolution of the patient and thus ... Biomarkers , Colorectal cancer is ... sexes. About 30,000 new cases are diagnosed each ...
(Date:9/17/2014)... DC A team of researchers working on a Carnegie ... coral growth rates have plummeted 40% since the mid-1970s. ... an important role in this perilous slowdown. , ... facing coral reefs, the team compared current measurements of ... Barrier Reef with similar measurements taken more than 30 ...
Breaking Biology News(10 mins):Size at birth affects risk of adolescent mental health disorders 2Size at birth affects risk of adolescent mental health disorders 3Five genes to predict colorectal cancer relapses 2Coral growth rate plummets in 30-year comparison 2
... Technology (Caltech) have devised a new techniqueusing a sheet ... of molecules. The technique, which was used to obtain ... at room temperature, can also be used to image ... and other biomolecules. A paper describing the method ...
... prototype model of the first implantable artificial kidney, in ... for dialysis. The device, which would include thousands ... mimic the metabolic and water-balancing roles of a real ... engineers, biologists and physicians nationwide, led by Shuvo Roy, ...
... is a joke no more. In a special September issue ... ( CBE-LSE ), the adage that biology is for science ... "Bio-math" or "math-bio" is in the future for students of ... research articles on new ways to integrate mathematical thinking into ...
Cached Biology News:Caltech chemists develop simple technique to visualize atomic-scale structures 2Caltech chemists develop simple technique to visualize atomic-scale structures 3UCSF unveils model for implantable artificial kidney to replace dialysis 2UCSF unveils model for implantable artificial kidney to replace dialysis 3You say, 'bio-math,' I say, 'math-bio': Crossing science education divide 2
(Date:9/17/2014)... -- MiMedx Group, Inc. (NASDAQ: MDXG ), ... protected regenerative biomaterials and bioimplants processed from human ... clinical study.    The study article, ... Trial Evaluating the Use of Dehydrated ... Therapy vs. Multi-layer Compression Therapy Alone in the ...
(Date:9/17/2014)... (PRWEB) September 17, 2014 Immunomic Therapeutics, ... Innovation Research (SBIR) grant to support the continued preclinical ... provide ITI with approximately $255,000 over one year to ... cause of food allergy, affect over one million Americans ... peanut allergy. Tree nut exposure is also a risk ...
(Date:9/17/2014)... , Sept. 17, 2014 Alternative Fuels Americas, ... to form a Special Purpose Vehicle in partnership with Jatro ... centric agro energy company. The SPV shall be called AFAI ... with AFAI as majority shareholder. The SPV shall pursue Jatropha ... , particularly Ethiopia . ...
(Date:9/17/2014)... FOREST, California , 17 de septiembre ... CYRX) ("la compañía"), principal proveedor mundial de ... de las ciencias de la vida, anunció ... compañía de logística global con sede en ... su base de clientes Europa en rápido ...
Breaking Biology Technology:MiMedx Multi-Center Randomized, Controlled VLU Clinical Study Published In Peer-Reviewed Journal 2MiMedx Multi-Center Randomized, Controlled VLU Clinical Study Published In Peer-Reviewed Journal 3MiMedx Multi-Center Randomized, Controlled VLU Clinical Study Published In Peer-Reviewed Journal 4Immunomic Therapeutics Awarded SBIR Grant to Develop Multi-Nut Allergy Immunotherapy 2Immunomic Therapeutics Awarded SBIR Grant to Develop Multi-Nut Allergy Immunotherapy 3AFAI Signs Joint Venture Agreement With Jatro Greentech Inc. 2AFAI Signs Joint Venture Agreement With Jatro Greentech Inc. 3Cryoport contrata a Broekman Group para mejorar su apoyo operativo y logístico en Europa 2Cryoport contrata a Broekman Group para mejorar su apoyo operativo y logístico en Europa 3Cryoport contrata a Broekman Group para mejorar su apoyo operativo y logístico en Europa 4Cryoport contrata a Broekman Group para mejorar su apoyo operativo y logístico en Europa 5
... Compendia Bioscience, Inc.,today announced the release and ... high-value product extension of Oncomine,Research Edition for ... includes custom gene filters, integration with Ingenuity,Pathway ... Concepts Map,including the ability to upload custom ...
... Offer Full Range of Fertility Services and ... Dr. John Jain, a,fertility specialist with ... the,country, announced today the grand opening of ... reproductive health center in Santa,Monica, California. The ...
... Features ... Renowned Investment Banker and Biotechnology Company Start-up Leader ... Stelios Papadopoulos, PhD Provides Keynote Address, BOSTON, ... Opportunities Investor Conference, New,England,s largest biotechnology investor forum, will ...
Cached Biology Technology:Compendia Bioscience Announces the Release and Availability of Oncomine(TM) Research Premium Edition 2Pioneer in Reproductive Medicine Opens The Country's First Comprehensive Fertility Practice 22007 Massachusetts Biotechnology Council MASS Opportunities Investment Conference Showcases Leading Growth Companies 22007 Massachusetts Biotechnology Council MASS Opportunities Investment Conference Showcases Leading Growth Companies 3
Amino Acid Analysis is performed using ion-exchange separation of the amino acids from acid hydrolysates, followed by ninhydrin detection. Typical quantities required are 0.1 to 0.5 mg, depending on...
ANTI CORTIS BIN GLOB...
ANTI S. ENTERID LPS...
... This DuoSet ELISA Development kit contains ... of sandwich ELISAs to measure natural and ... and serum. Each kit contains sufficient ... 96-well plates, provided that the following conditions ...
Biology Products: