Navigation Links
Stem cells battle for space
Date:12/4/2009

The body is a battle zone. Cells constantly compete with one another for space and dominance. Though the manner in which some cells win this competition is well known to be the survival of the fittest, how stem cells duke it out for space and survival is not as clear. A study on fruit flies published in the October 2 issue of Science by Johns Hopkins researchers describes how stem cells win this battle by literally sticking around.

"Our work exemplifies how one signal coordinately maintains two types of stem cells in a single niche, or microenvironment," says Erika Matunis, Ph.D., associate professor of cell biology at the Johns Hopkins School of Medicine. "What we found may emerge as common themes of mammalian stem cell niches as they become better characterized."

To tackle the stem cell competition quandary, the team looked at fruit fly testes where two different stem cells exist: germline stem cells which give rise to sperm, and somatic stem cells which develop into non-reproductive cell types.

Using genetics, the researchers grew flies lacking the SOCS protein, which controls other molecules that promote stem cell growth. SOCS normally ensures that the right numbers of stem cells are present in the stem cell niche, a region at the far end of the fly testis where new cells are born. In a normal testis, the germline stem cells are surrounded by somatic stem cells at a ratio of about one germline stem cell for every two somatic stem cells.

The researchers isolated testes from flies lacking SOCS and, under a microscope, counted the number of germline stem cells and somatic stem cells. They found that nearly half of the germline stem cells were gone and the somatic stem cells appeared to be occupying that space.

"The somatic stem cells almost look like they've invaded the niche area," says Melanie Issigonis, a graduate student in the Biochemistry, Cellular, and Molecular Biology graduate program at Johns Ho
'/>"/>

Contact: Audrey Huang
audrey@jhmi.edu
410-614-5105
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2

Related biology news :

1. ESF EURYI award winner aims to stop cancer cells reading their own DNA
2. Newly created cancer stem cells could aid breast cancer research
3. AIDS interferes with stem cells in the brain
4. Clemson scientists shed light on molecules in living cells
5. Social habits of cells may hold key to fighting diseases
6. UF scientists reveal how dietary restriction cleans cells
7. Human derived stem cells can repair rat hearts damaged by heart attack
8. Scientists identify embryonic stem cells by appearance alone
9. Cells united against cancer
10. Pittsburgh scientists identify human source of stem cells with potential to repair muscle
11. U of M begins nations first clinical trial using T-reg cells from cord blood in leukemia treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2014)... explorer Roald Amundsen became the first man to reach ... 100 years later, an international team of scientists led ... have proven that air pollution from industrial activities arrived ... collected from widely spaced locations around the Antarctic continent, ... accurate and precise reconstruction to date of lead pollution ...
(Date:7/27/2014)... in the southern Western Ghats, a mountain range along the ... time that any mayfly belonging to the genus Labiobaetis ... species, called Labiobaetis soldani , "is named in honor ... understanding of the Ephemeroptera of Palaearctic and Oriental realms," according ... mayfly in the Journal of Insect Science . , ...
(Date:7/27/2014)... a single computer cannot always find the solution a ... a cluster of computers that analyze a massive data ... web history to present you with targeted ads, and ... or movie. But big data is about more than ... activity are generating unprecedented quantities of information. That data ...
Breaking Biology News(10 mins):Industrial lead pollution beat explorers to the South Pole by 22 years and persists today 2Industrial lead pollution beat explorers to the South Pole by 22 years and persists today 3New tools help neuroscientists analyze 'big data' 2New tools help neuroscientists analyze 'big data' 3New tools help neuroscientists analyze 'big data' 4New tools help neuroscientists analyze 'big data' 5
... Hollywood, FL (December 12, 2013) A new study shows ... develop depression. The data were presented today at the American ... chronic disorder with a devastating impact on the quality of ... the disorder. The underlying causes of the disorder remain something ...
... December 12, 2013 The critical enzyme beta-secretase1 (BACE1) is ... (AD). Scientists have now found increased levels of BACE1 in ... is important for conversion of mild cognitive impairment to AD ... are published in the January issue of The American ...
... to fix sleep disturbances in mice with traumatic brain injuries ... of thousands of people who have long-term and debilitating sleep ... found helpful was giving the mice something all humans produce ... chain amino acids. "If further research confirms what this ...
Cached Biology News:Peripheral immune system may regulate vulnerability to depression 2Enzyme BACE1 may be important in predicting onset of Alzheimer disease 2Dietary amino acids improve sleep problems in mice with traumatic brain injury 2Dietary amino acids improve sleep problems in mice with traumatic brain injury 3
(Date:7/25/2014)... 25, 2014 Research and Markets ... Metabolomics Market 2014-2018" report to their offering. ... Metabolomics or Metabonomics is the scientific study ... a new experimental technique that is being widely ... Metabolites are small molecules that are present in ...
(Date:7/25/2014)... Diego, CA (PRWEB) July 25, 2014 WABC ... For Your Pet with Lorry Young will be hosting ... to talk about stem cell therapy in pets. Dr. ... the benefits of stem cell therapy for pets suffering from ... moving the Regenerative Veterinary Medicine industry forward. , Young has ...
(Date:7/25/2014)... 25, 2014 Lawrence Livermore scientists Charles ... Reuters list of " The World's Most Influential Scientific ... the 3,000 researchers who were identified by analyzing citation ... who published the highest-impact work (2002-2012 and 2012-2013). The ... combustion modeling . , "This recognition is a ...
(Date:7/25/2014)... July 25, 2014 /PRNewswire-iReach/ -- Xybion Corporation, the ... global corporations operating in highly regulated industries, announced ... annual Global User Group Conference, Xybion International Exchange, ... Philadelphia, Pennsylvania at the Sheraton Society ... This year,s conference theme ...
Breaking Biology Technology:Global Metabolomics Market 2014-2018: Key Vendors are Agilent, Bio-Rad, Bruker, Human Metabolome and Metabolon 2Robert J. Harman, DVM, Founder and CEO of Vet-Stem, Inc. to Join New York Radio Host Lorry Young in Upcoming Episode of A “Paws” For Your Pet 2Robert J. Harman, DVM, Founder and CEO of Vet-Stem, Inc. to Join New York Radio Host Lorry Young in Upcoming Episode of A “Paws” For Your Pet 3Scientists Burst onto Influential List for Combustion Research 2Scientists Burst onto Influential List for Combustion Research 3Scientists Burst onto Influential List for Combustion Research 4Xybion Announces It Will Host International User Conference in Philadelphia 2Xybion Announces It Will Host International User Conference in Philadelphia 3
... CHARLOTTESVILLE, Va., Oct. 5, 2011 ZyGEM Corp. Ltd., ... analysis of DNA and other nucleic acids, today announced ... forensic GEM® Tissue kit can rapidly extract DNA from ... be used to produce accurate, reliable and reproducible DNA ...
... Hospital and Medical Center and the University of Arizona College ... the Valley Fever Center based at the hospital.  The center ... than 30 years of experience in treating and researching Valley ... Tucson in 1996. The center plans to see ...
... Oct. 4, 2011 MSC Care Management, the ... to post-discharge and post-injury workers, compensation claimants nationwide, ... Services, a national company also focused on the ... comprehensive surgical implant cost management solution, known as ...
Cached Biology Technology:Application Note Shows ZyGEM's forensicGEM® Tissue Facilitates Forensic Casework by Rapidly and Reproducibly Extracting DNA From Human Hair 2Application Note Shows ZyGEM's forensicGEM® Tissue Facilitates Forensic Casework by Rapidly and Reproducibly Extracting DNA From Human Hair 3St. Joseph's Hospital, University of Arizona Create Valley Fever Center in Phoenix 2MSC to Offer Surgical Implant Cost Management Solution through Acquisition of Integrated Healthcare Services 2
Mouse monoclonal antibody raised against a partial recombinant STAU2. NCBI Entrez Gene ID = STAU2...
...
Mouse polyclonal antibody to NR2F2 - nuclear receptor subfamily 2, group F, member 2...
... Hybridization Wash Pack provides optimized blocking ... Preparation Quality Clarifier: Ready-to-use wash solutions ... SigmaScreen(tm) APS Coated Slides for Microarrays ... Hybridization Blocking Buffer: 1L • Microarray ...
Biology Products: