Navigation Links
Stem cells and cancer: cancer pathways that also control the adult stem cell population
Date:4/10/2008

Speaking today (10 April) at the UK National Stem Cell Network Annual Science Meeting in Edinburgh, Professor Alan Clarke from Cardiff University describes his work to investigate a mechanism that normally drives adult stem cells to repair the intestine. Together with his colleague Owen Sansom from the University of Glasgow, he has found that if things go wrong and a crucial gene called Apc is lost or damaged, then this normal function of controlling the adult stem cell population breaks down and ultimately leads to a tumour. This research is funded by the UK Biotechnology and Biological Sciences Research Council (BBSRC) and Cancer Research UK.

Professor Clarke, Cardiff School of Biosciences said: If we are to use adult stem cells for therapy then we must understand how they behave normally and what sometimes triggers them to go wrong and potentially cause cancer. Otherwise we may never be able to fully exploit their potential, or do so safely. That is why we have chosen to research intestinal repair as an example of how adult stem cells work and what happens when the pathways that control them go wrong.

The team from Cardiff University has used genetic technology to manipulate intestinal stem cells and mimic the process by which a part of the intestine called the crypts is regenerated following high levels of DNA damage or injury. By doing this, they have found that a mechanism called Wnt signalling drives this process and is necessary to send stem cells down the route to become replacement cells in the damaged part of the intestine. Under normal circumstances Wnt signalling is turned down once the stem cells have done their job. If this does not happen, then more and more cells are added to the crypt and ultimately a tumour forms.

Professor Clarke added: It has been known for some time that loss of or damage to Apc within the intestinal crypt cells can lead to cancer, but what hasnt been clear is what it actually does. Ou
'/>"/>

Contact: Matt Goode
matt.goode@bbsrc.ac.uk
01-793-413-299
Biotechnology and Biological Sciences Research Council
Source:Eurekalert

Page: 1 2

Related biology news :

1. ESF EURYI award winner aims to stop cancer cells reading their own DNA
2. Newly created cancer stem cells could aid breast cancer research
3. AIDS interferes with stem cells in the brain
4. Clemson scientists shed light on molecules in living cells
5. Social habits of cells may hold key to fighting diseases
6. UF scientists reveal how dietary restriction cleans cells
7. Human derived stem cells can repair rat hearts damaged by heart attack
8. Scientists identify embryonic stem cells by appearance alone
9. Cells united against cancer
10. Pittsburgh scientists identify human source of stem cells with potential to repair muscle
11. U of M begins nations first clinical trial using T-reg cells from cord blood in leukemia treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/22/2014)... key molecular cog in a plant,s biological clock ... based on temperature. , Transcription factors, or genetic switches, ... such as light, rain, soil quality, or even ... USC has isolated one, called FBH1, that reacts to ... needed while in keeping it on a consistent track. ...
(Date:9/22/2014)... the Society of Environmental Toxicology and Chemistry (SETAC) held ... prioritize the scientific research needed to understand the risks ... environment. The effort was extended, and results were ... international journal, Integrated Environmental Assessment and Management ... podcast interviewing the lead author of the study, Murray ...
(Date:9/22/2014)... YORK CITY (September 22, 2014)The Brain & ... the award of NARSAD Young Investigator Grants ... 200 of the world,s most promising young ... for groundbreaking neurobiological research will seek to ... strategies for psychiatric disorders that affect one ...
Breaking Biology News(10 mins):Genetic switch regulates a plant's internal clock based on temperature 2Priorities for research on pharmaceutical and personal care products in the environment 2Brain & Behavior Research Foundation awards 200 NARSAD Young Investigator grants 2
... new use as an adjuvant to cancer therapy, providing an ... study published in the Feb. 15 issue of Clinical Cancer ... Gallez, Ph.D., professor of pharmacy at the Université de Louvain ... A into two types of mouse tumors, the tumors' cellular ...
... H5N1 influenza samples in Southeast Asia shows not only ... are related but also that they belong to two ... for Disease Control and Prevention report their findings today ... "As the virus continues its geographic expansion, it is ...
... in Africa declared that a dramatic rise in tuberculosis (TB) ... TB case notifications have increased as much as four-fold over ... HIV. When individuals are infected with both HIV and TB, ... to active TB. , To combat the problem, the ...
Cached Biology News:Botox could help target resistant tumors for treatment 2Botox could help target resistant tumors for treatment 3Study outlines genetic differences between potential pandemic influenza strains 2
(Date:9/22/2014)... This is a professional and in-depth study ... industry in Global and China. The report provides a ... industry chain structure. Global market analysis and Chinese domestic ... developments, trends and competitive landscape of the market. A ... offered. , The report also focuses on development policies ...
(Date:9/22/2014)... , Sept. 22, 2014 Research ... "Global and Chinese Microcrystalline Cellulose Industry Report 2014" ... Global and Chinese Microcrystalline Cellulose Industry Report 2014 is ... of the global microcrystalline cellulose industry with a focus ... a basic overview of the industry including definitions, classifications, ...
(Date:9/22/2014)... N.J. , Sept. 22, 2014  WIRB-Copernicus ... and ethical review services for clinical research, announced ... (WIRB) has been reaccredited by the Association ... (AAHRPP), which endeavors to improve safeguards for clinical ... Donald A. Deieso , Ph.D., commented, "It ...
(Date:9/21/2014)... at the University of Basel in Switzerland have ... a charged molecule for the first time. These ... measurements of molecular properties and may also contribute ... technology. The results were published in the scientific ... study of the interaction between matter and light, ...
Breaking Biology Technology:m-Phenylenediamine Industry: mPDA Global & China Trend Analysis Now Available at ReportsnReports.com 2m-Phenylenediamine Industry: mPDA Global & China Trend Analysis Now Available at ReportsnReports.com 3Global and Chinese Microcrystalline Cellulose Industry Report 2014 2Western IRB (WIRB) Awarded AAHRPP Reaccreditation 2Uncovering the forbidden side of molecules 2
... Inc. (OTC Bulletin Board: NWBO ) (NW Bio) joined ... over the course of more than 13 months, the parties ... brain cancer in Germany. As a result, the Company is ... with both its clinical trial program and Hospital Exemption cases ...
... J.D., will offer her expert perspective on  the ... she presents "EHRs: Meaningful Use & Beyond" during ... held  April 24-26, 2012, at the Thelma Keller ... During the presentation, Pita, who serves as executive ...
... facilitated the evolution and complexity of terrestrial organisms, including human ... by those organisms, which in turn were able to generate ... oxygen molecules work inside the body, more attention is being ... to thwart them. A number of environmental ...
Cached Biology Technology:Northwest Bio and Fraunhofer IZI Announce Milestones Reached 2Northwest Bio and Fraunhofer IZI Announce Milestones Reached 3Northwest Bio and Fraunhofer IZI Announce Milestones Reached 4Prognosis HIS Executive Slated To Offer EHR Advice At Illinois Rural Health Association Conference 2Avocado Oil: The 'Olive Oil Of The Americas'? 2Avocado Oil: The 'Olive Oil Of The Americas'? 3Avocado Oil: The 'Olive Oil Of The Americas'? 4
This monoclonal antibody recognizes the light chain of human Factor XII and at 100 nM inhibits 50% of Factor XII activity. It may be used in ELISA to detect human Factor XII and in coagulation assay...
Anti-LC3 Polyclonal Antibody Research Focus: cell surface antigens Storage: -20C Shipping Temperature: +4C...
Rabbit polyclonal to Xanthine Oxidase (HRP) ( Abpromise for all tested applications). Antigen: Xanthine Oxidase (from Bovine Buttermilk) Entrez Gene ID: 7498 Swiss Protein ID: P47989...
Phospho- (Ser) 14-3-3 Binding Motif (4E2) Mouse mAb...
Biology Products: