Navigation Links
Stem cells: In search of a master controller
Date:5/6/2010

terplay among the three HSC regulatory proteins in the Scl-Gata2-Fli1 triad. Based on previous studies at Cambridge, it was obvious that the triad plays an essential role in HSC development. In creating their computer model, Igoshin and Narula were able to quantify the way the three interact and thus shed light on their combined role in regulating HSCs.

To qualify as a master regulator, the triad needed to meet two criteria. It had to act as a "bistable" switch, a one-way button that toggled from the "replenish HSC" state to the "differentiate" state. Second, it needed to ignore extraneous signals and throw the switch only when a signal persisted.

"In examining the results from the model, we found the triad did have the characteristics of a master regulator," Narula said. "The first time it's switched on, all the cells stay on. It also handles deactivation in a controlled manner, so that some cells differentiate and get deactivated and others don't. Finally, it has the ability to discern whether or not the level of signal is present only for a short burst or for a significantly long time."

Igoshin said additional experimental research is needed to verify the computer model's prediction that the Scl-Gata2-Fli1 triad is the master-level controller for HSCs. However, he said the prediction is particularly intriguing in light of previous studies that suggest other similarly wired regulatory triads are key players in other types of stem cells, including embryonic stem cells.

"It's possible that this triad motif is reused elsewhere," Igoshin said. "The proteins could be different in each case, but the motif structure of their interconnections is common and may be repeated elsewhere in nature. That's one of the most intriguing aspects of this research."


'/>"/>

Contact: Jade Boyd
jadeboyd@rice.edu
713-348-6778
Rice University
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Type 1 diabetes triggered by lazy regulatory T-cells: McGill researchers
2. From sheet metal elements to host cells: DFG launches 10 new collaborative research centers
3. HIV-1 protease inhibitor induced oxidative stress in pancreatic B-cells: thymoquinone protection
4. Induced neural stem cells: Not quite ready for prime time
5. Research shows skeleton to be endocrine organ
6. Newly created cancer stem cells could aid breast cancer research
7. Dominant cholesterol-metabolism ideas challenged by new research
8. Researchers identify proteins involved in new neurodegenerative syndrome
9. Texas researchers and educators head for Antarctica
10. MGH researchers describe new way to identify, evolve novel enzymes
11. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Stem cells: In search of a master controller
(Date:8/21/2014)... that has implications for life in other extreme environments, ... system, LSU Associate Professor of Biological Sciences Brent Christner ... or NSF, this week published a paper confirming that ... 800 meters (2600 feet) beneath the surface of the ... that more than 400 subglacial lakes and numerous rivers ...
(Date:8/21/2014)... the Fram Strait is a key region in the global ... Greenland and Svalbard warm Atlantic water flows to the north ... Arctic water masses and sea ice push their way out ... of the Atlantic water cools here on its way to ... the water caused in this manner drives the global band ...
(Date:8/21/2014)... of the water window? It consists of radiations in ... absorbed by the water in biological tissues. New theoretical ... radiations within the water window. These could be the ... image of the biological samples or to be used ... the physical mechanism needed to efficiently generate the harmonic ...
Breaking Biology News(10 mins):800 meters beneath Antarctic ice sheet, subglacial lake holds viable microbial ecosystems 2800 meters beneath Antarctic ice sheet, subglacial lake holds viable microbial ecosystems 3800 meters beneath Antarctic ice sheet, subglacial lake holds viable microbial ecosystems 4Arctic sea ice influenced force of the Gulf Stream 2Arctic sea ice influenced force of the Gulf Stream 3Water window imaging opportunity 2
... was identified by ancient Egyptians. Genetic analysis done by ... the animal,s range and including DNA from mummified crocodile remains ... name., "This paper provides a remarkable surprise: the Nile crocodile ... demonstrates two species - living side-by side - constitute what ...
... Bone marrow-derived stem cells (BMDCs) have been recognized as ... cell populations in a variety of organs under both normal ... repairing damaged brain tissue or helping to restore lost neural ... cerebellum at the back of the brain. In a recent ...
... Webb from the School of Chemical Engineering and Analytical ... and Excellence Award for Bioprocessing. They received the ... co-production of fuels and chemicals: The biochemical production of ... place last month at the ICC in Birmingham. ...
Cached Biology News:Bone marrow-derived cells differentiate in the brain through mechanisms of plasticity 2Award success for University 2
(Date:8/21/2014)... 21, 2014 Telomere Biosciences, LLC (Telomere ... "TELO-20 for Dogs" with Telomerase Activation Complex ... the world for dogs. Telomeres are the protective ... the body. A wealth of ground-breaking research by ... Science and Aging, including Nobel laureates, has demonstrated ...
(Date:8/21/2014)... Rochelle, N.Y. (PRWEB) August 21, 2014 ... is the first private college in the Mid-Hudson Region ... College will now begin accepting applications from qualified “high-technology” ... , “We are very pleased to have been selected ... support Governor Cuomo’s transformative initiative to stimulate economic development ...
(Date:8/21/2014)... , Aug. 21, 2014  Decision Resources Group ... Brazil and Mexico ... of several newly approved agents, the anticipated label ... and the launch of emerging biologics will substantially ... particular, the emerging IL-5 inhibitors will introduce a ...
(Date:8/21/2014)... -- Mathematic studies at the Program for Evolutionary Dynamics ... the Jeffrey Epstein VI Foundation , have shown that ... for elimination. These aggressive cells are the driver mutations that ... map of what to look for when examining tumors, comes ... cells can be extracted from biopsy, it,s very difficult to ...
Breaking Biology Technology:Telomere Biosciences Announces: TELO-20 for Dogs, the World's First Telomere-Lengthening Supplement for Dogs, to Promote Healthy Aging and Longevity 2Telomere Biosciences Announces: TELO-20 for Dogs, the World's First Telomere-Lengthening Supplement for Dogs, to Promote Healthy Aging and Longevity 3The College of New Rochelle Becomes First Private College in Mid-Hudson Region to Earn START-UP NY Designation 2The College of New Rochelle Becomes First Private College in Mid-Hudson Region to Earn START-UP NY Designation 3Asthma Agents Currently Face a Suboptimal Coverage Environment in Brazil and Mexico, and as the Treatment Armamentarium Expands, Competitiveness Will Further Intensify 2Asthma Agents Currently Face a Suboptimal Coverage Environment in Brazil and Mexico, and as the Treatment Armamentarium Expands, Competitiveness Will Further Intensify 3Science Power Jeffrey Epstein and Harvard University Fund Project to Visually Stop Tumor Growth 2
... , , Multiporator , , , , , , ... Protocol No. 4308 915.029 11/1999 , , , ... , Cell line , ... Transfection with , Plasmid pEGFP-N1 (in bidistilled H 2 O), , ...
... , , , , , , , Multiporator / Electroporator 2510 , ... , Transformation Protocol , Protocol ... , , , , , ... , , Cell type , ...
... , , , , Multiporator / Electroporator 2510 , , , , ... Transformation Protocol , Protocol No. 4308 915.528 01/2002 , ... , , , ... , Cell type , Bacteria, gram negative, ...
Cached Biology Technology:293 T 2Staphylococcus aureus 2Pseudomonas aeruginosa 2
Bethyl Laboratories packages antibodies, conjugates and calibrators to provide quantitative ELISA kits. Each kit contains the following components, sufficient for 1000 single well assays....
QML offers standard and customized paraffin embedded tissue blocks....
... include: ,ISH Protocol Development ,Probe ... ,RNA and DNA Screenings in ... Tissues ,Double Labeling of RNA ... Tissues ,RNA and DNA Localization ...
... involves the optimization of immunostaining. ... of the primary antibody, selection ... (e.g. Alk. Phos., HRP, fluorescence, ... detection, evaluation by light or ...
Biology Products: