Navigation Links
Stem cell transplants help kidney damage
Date:2/14/2011

Tampa, Fla. (Feb. 14, 2011) Transplanting autologous renal progenitor cells (RPCs), (kidney stem cells derived from self-donors), into rat models with kidney damage from pyelonephritis - a type of urinary infection that has reached the kidney - has been found to improve kidney structure and function.

The study, authored by a research team from the Tehran University of Medical Sciences, is published in the current issue of Cell Medicine [1(3)] and is freely available on-line at: http://www.ingentaconnect.com/content/cog/cm .

"Advancements in stem cell therapies and tissue engineering hold great promise for regenerative nephrology," said Dr. Abdol-Mohammad Kajbafzadeh, corresponding author. "Our RPC transplant study demonstrated benefits for pyelonephritis, a disease characterized by severe inflammation, renal function impairment and eventual scarring, and which remains a major cause of end-stage-renal disease worldwide."

The researchers divided 27 rats into three groups, two of which were modeled with an induced pyelonephritis in their right kidneys, while the third group did not have induced disease. RPCs were obtained from the diseased animals' left kidneys and injected into the right kidney six weeks later. Two weeks after injection, tubular atrophy was reduced. After four weeks, fibrosis was reduced and after sixty days, right renal tissue integrity was "significantly improved."

"We propose that kidney augmentation was mainly due to functional tissue regeneration following cellular transplantation," said Dr. Kajbafzadeh. "Kidney-specific stem/progenitor cells might be the most appropriate candidates for transplantation because of their inherent organ-specific differentiation and their capacity to modulate tissue remodeling in chronic nephropathies."

The researchers concluded that because renal fibrosis is a common and ultimate pathway leading to end-stage renal disease, amelioration of fibrosis might be of major clinical relevance.

"Transplanting RPCs showed the potential for partial augmentation of kidney structure and function in pyelonephritis," said Dr. Kajbafzadeh. "This is one of the first studies to demonstrate improved renal function after cell transplantation. The translation of this study into larger clinical models will be very relevant to validate the success of this small animal study." said Dr. Amit Patel, Section Editor Cell Medicine, Associate Professor of Surgery, University of Utah.


'/>"/>

Contact: David Eve
cellmedicinect@gmail.com
Cell Transplantation Center of Excellence for Aging and Brain Repair
Source:Eurekalert

Related biology news :

1. Free radicals in cornea may contribute to Fuchs dystrophy, most common cause of corneal transplants
2. Frozen flies may yield secrets for human organ transplants
3. Cell transplants may benefit children with cerebral palsy
4. Bone marrow cell transplants to benefit those with heart disease
5. Gene mismatch influences success of bone marrow transplants
6. Gene mutation increases drug toxicity, rejection risk in pediatric kidney transplants
7. Researchers engineer pancreatic cell transplants to evade immune response
8. High blood sugars impact on immune system holds clues to improving islet cell transplants
9. Researchers unlock the potential for exploring kidney regeneration
10. Seeing kidney injury, as it happens
11. Kidney gene implicated in increased heart failure risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/6/2017)... 2017 Forecasts by Product Type ... by End-Use (Transportation & Logistics, Government & Public Sector, ... Fossil Generation Facility, Nuclear Power), Industrial, Retail, Business Organisation ... Are you looking for a definitive report on the ... ...
(Date:4/3/2017)... , April 3, 2017  Data ... precision engineering platform, detected a statistically significant ... product prior to treatment and objective response ... the potential to predict whether cancer patients ... to treatment, as well as to improve ...
(Date:3/28/2017)... 2017 The report "Video Surveillance ... Servers, Storage Devices), Software (Video Analytics, VMS), and Service ... Forecast to 2022", published by MarketsandMarkets, the market was ... projected to reach USD 75.64 Billion by 2022, at ... base year considered for the study is 2016 and ...
Breaking Biology News(10 mins):
(Date:5/23/2017)... CA (PRWEB) , ... May 23, 2017 , ... ... publication of “Label-free isolation of prostate circulating tumor cells using Vortex microfluidic technology ... the result of a collaboration with Dr. Dino Di Carlo and Dr. Matthew Rettig ...
(Date:5/23/2017)... (PRWEB) , ... May 23, 2017 , ... ... Works as Vice President of Clinical Operations. She brings years of expertise ... Yaupon Therapeutics. From her professional foundation as a licensed occupational therapist, through a ...
(Date:5/23/2017)... ... , ... Cambridge Semantics , the leading provider of Big Data management ... and Expo in Boston May 23-25 with a featured speaker and solution demos ... Lake is also a finalist for the Best of Show award. , James LaPointe, ...
(Date:5/22/2017)... ... May 22, 2017 , ... Stratevi, a boutique firm ... the East Coast. It has opened an office in downtown Boston at 745 Atlantic ... it increasingly more important to generate evidence on the value they provide, not just ...
Breaking Biology Technology: