Navigation Links
Stem-cell transplantation improves muscles in MD animal model, UT Southwestern researchers report
Date:1/20/2008

DALLAS Jan. 20, 2008 Using embryonic stem cells from mice, UT Southwestern Medical Center researchers have prompted the growth of healthy and more importantly, functioning muscle cells in mice afflicted with a human model of Duchenne muscular dystrophy.

The study represents the first time transplanted embryonic stem cells have been shown to restore function to defective muscles in a model of muscular dystrophy.

The researchers newly developed technique, which involves stringent sorting to preserve all stem cells destined to become muscle, avoids the risk of tumor formation while improving the overall muscle strength and coordination of the mice, the researchers found.

The mice used in the study lacked dystrophin, the same protein that humans with the fatal wasting disease also are missing.

The study, headed by Dr. Rita Perlingeiro, assistant professor of developmental biology and molecular biology, is available online today and in the February issue of Nature Medicine.

We envision eventually developing a stem-cell therapy for humans with muscular dystrophy, if we are able to successfully combine this approach with the technology now available to make human embryonic stem cells from reprogrammed skin cells, Dr. Perlingeiro said. These cells can be transplanted into the muscle, and they cause muscle regeneration resulting in stronger contractility.

The study represents a major step in the field, she said, because the researchers were able to tease out exactly the cells they wanted.

The problem had been that embryonic stem cells make everything, Dr. Perlingeiro said. They make a great variety of cells. The trick is to pull out only the one type you want.

The UT Southwestern researchers focused on manipulating genes that are active in the very early stages as embryonic stem cells start to develop into more specialized cells. At first, they activated a gene called Pax3, w
'/>"/>

Contact: Aline McKenzie
aline.mckenzie@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Reprogramming the debate: stem-cell finding alters ethical controversy
2. Clearance of hepatitis C viral infection after liver transplantation
3. Exercise improves thinking, reduces diabetes risk in overweight children
4. Endobronchial valve significantly improves emphysema
5. Teamwork improves learning and career success
6. New clinical data shows chromium picolinate improves cognitive function
7. How molecular muscles help cells divide
8. Small animal imaging facility is big boon to research
9. Report: African, Asian, Latin American farm animals face extinction
10. UT researcher sheds new light on hybrid animals
11. Penn Veterinary Medicine report new strategy to create genetically-modified animals
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Stem-cell transplantation improves muscles in MD animal model, UT Southwestern researchers report
(Date:9/29/2014)... from 2009, "human activities in this area of the world ... is increasingly grown for use as a cooking oil and ... has become the most widely produced edible oil in the ... that of soybean oil. , The environmental effects of such ... grow the crop, and the preferred method is fire. The ...
(Date:9/29/2014)... team says recently identified radiation detection properties of a ... for homeland security and medical advances. , In a ... of Optics Letters , UT Arlington Physics Professor ... to fabricate transparent nanoscintillators by heating nanoparticles composed of ... formed. A scintillator refers to a material that ...
(Date:9/29/2014)... Washington State University have concluded that nondigestible compounds ... may help prevent disorders associated with obesity. The ... these compounds in apple cultivars grown in the ... the journal Food Chemistry ., "We know ... of these nondigestible compounds but there are differences ...
Breaking Biology News(10 mins):UT Arlington researchers develop new transparent nanoscintillators for radiation detection 2UT Arlington researchers develop new transparent nanoscintillators for radiation detection 3An apple a day could keep obesity away 2
... tough for wildlife living at the frontier between Uganda and ... in a national park and wildlife preserve on the Congolese ... an adjoining Ugandan park. And yet, the profusion of ... individuals of the emblematic African lion, according to new research ...
... in Nevada for turning algae into biofuel has successfully ... of Nevada, Reno. The project is on track to ... energy source in Nevada. University researchers have ... part of their collaborative algae-to-biofuels project with their industry ...
... key phase in the repair process of damaged human ... team of researchers at the University of California, Davis. ... by a protein known as Rad51, which is linked ... The breakthrough comes a decade after Stephen ...
Cached Biology News:Research uncovers surprising lion stronghold in war-torn central Africa 2Research uncovers surprising lion stronghold in war-torn central Africa 3Success for first outdoor, large-scale algae-to-biofuel research project in Nevada 2Human DNA repair process recorded in action 2
(Date:9/30/2014)... Whitehouse Laboratories is pleased to ... Parenteral Drug Association (PDA) to host a unique ... closure integrity testing. This lecture/laboratory course will examine the ... detailed in the recently proposed revision to USP 1207 ... will span container closure integrity testing (leak testing) critical ...
(Date:9/29/2014)... in Iraq and Afghanistan, more than 300,000 soldiers have ... caused by exposure to bomb blasts and in ... of traumatic brain injury can range from the mild, ... impairments in memory and cognition. , Since 2007, ... importance and complexity of this problem, and has made ...
(Date:9/29/2014)... Present-day lithium batteries are efficient but involve a ... from alfalfa (lucerne seed) and pine resin and ... come up with a highly interesting alternative. Their ... journal ChemSusChem . , ,We think our ... energy-efficient solutions for the batteries of the future, ...
(Date:9/29/2014)... CAMBRIDGE, Mass. , Sept. 29, 2014  Atlas ... promising life sciences and technology innovation, today announced that ... of Epizyme (NASDAQ: EPZM ), is joining ... effective October 1, 2014. At Atlas, Rhodes ... build groundbreaking companies. He brings an accomplished record in ...
Breaking Biology Technology:Whitehouse Laboratories to Partner with PDA for Educational Course on Container Closure Integrity Testing 2Whitehouse Laboratories to Partner with PDA for Educational Course on Container Closure Integrity Testing 3Whitehouse Laboratories to Partner with PDA for Educational Course on Container Closure Integrity Testing 4Modeling shockwaves through the brain 2Modeling shockwaves through the brain 3Modeling shockwaves through the brain 4Smart, eco-friendly new battery to solve problems 2Atlas Venture Names Jason Rhodes, Veteran Investor and President and CFO of Epizyme, As Partner on Life Sciences Investing Team 2
... ... efficient. With the most available leg-room, energy efficient impellers, and new service-friendly control panel, ... ... The all-new Allergard 619 Animal Transfer Station (ATS) from NuAire is ergonomic, portable, and ...
... ... and a “fascinatingly weird” ancient culture. , ... (PRWEB) June 11, 2010 -- U.S. nonprofit The OTS Foundation has devised ... megalithic architects in Frequently Asked Question format. With content drawn from a handbook in ...
... , ... more prevalent in clinical research, key issues around open source technology are highlighted at leading ... Washington, DC ... year’s annual meeting of the Drug Information Association (DIA). The DIA Annual Meeting ...
Cached Biology Technology:The Allergard 619: an All-new Animal Transfer Station from NuAire 2New tool for exploring the ancient world. 2Open Source Clinical Trials Software Featured at the 46th DIA Annual Meeting 2Open Source Clinical Trials Software Featured at the 46th DIA Annual Meeting 3
45° Fixed Angle Rotor for use in the IEC Centra CL2, Centra CL3/CL3R, HN-SII, and the Centra-MP4/MP4R....
A camera based compact unit for high speed scanning of 2D barcoded tubes in a cluster rack. This reader has been designed to read both 96 and 48 tube rack configurations and be compatible with common...
... The inductive drives of VARIOMAG Magnetic ... as motors, belts, or mechanical bearings, making ... In addition, the VARIOMAG inductive drive can ... water, dust or microorganisms. This is why ...
PTFE/red rubber septum silver aluminum seal ,11 mm seal diam. ...
Biology Products: