Navigation Links
Stem cell success points to way to regenerate parathyroid glands
Date:9/29/2009

ANN ARBOR, Mich. An early laboratory success is taking University of Michigan researchers a step closer to parathyroid gland transplants that could one day prevent a currently untreatable form of bone loss associated with thyroid surgery.

The scientists were able to induce embryonic stem cells to differentiate into parathyroid cells that produced a hormone essential to maintaining bone density. The laboratory results in live cell cultures, published in Stem Cells and Development, need to be tested in further pre-clinical studies.

Parathyroid glands, four glands each the size of a rice grain that lie next to the thyroid in the neck, are easily damaged when surgeons operate on patients with cancerous or benign thyroid tumors. Without their calcium-regulating hormone, patients can develop osteomalacia, a severe form of bone loss similar to rickets that affects tens of thousands of people in the United States with muscle cramps and numbness in the hands and feet.

"We used human embryonic stem cells as a model for ways to work out the recipe to make parathyroid cells," says Gerard M. Doherty, M.D., chief of endocrine surgery and Norman W. Thompson Professor of Endocrine Surgery at U-M Medical School.

The research illustrates the payoff of rapidly increasing knowledge about how embryonic stem cells give rise to other kinds of cells. That knowledge can be the springboard for influencing other cells to regenerate damaged parts of the body.

Doherty's team used embryonic stem cells from a Bush administration-approved embryonic stem cell line to test a way to produce functioning, differentiated parathyroid cells to transplant into a patient and restore function.

With the recipe worked out, Doherty's team anticipates developing a treatment that doesn't use embryonic stem cells.

"We anticipate taking a person's own cells and making them into parathyroid cells," Doherty says. Using the patient's own cells should eliminate the risk of rejection.

What's next

Having demonstrated a method for leading embryonic stem cells to produce parathyroid cells, the team hopes to be able to repeat those steps using cells from the patient's own thymus gland. The method involves no genetic modification of cells, a key goal of Doherty's team.

"We want to have a process that will allow us to reintroduce cells into the patient's body safely," Doherty says.

Any successful treatment in people is five to 10 years away.


'/>"/>

Contact: Anne Rueter
arueter@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert

Related biology news :

1. Layered approach may yield stronger, more successful bone implants
2. NASA keeps eye on ozone layer amid Montreal Protocols success
3. Life on Mars pregnancy test successfully launched
4. New book presents successful strategies for probing genetic variation
5. A new milestone in the GMES Space Component Program successfully achieved
6. MIT Holding, Georgia Southern University, and MEVLABS successfully test the PROVECTOR
7. Age increases chance of success as two-timer
8. Teamwork improves learning and career success
9. Researchers successfully simulate photosynthesis and design a better leaf
10. Predicting growth hormone treatment success
11. Study links success of invasive Argentine ants to diet shifts
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/5/2017)... 5, 2017 Today HYPR Corp. , ... server component of the HYPR platform is officially ... end-to-end security architecture that empowers biometric authentication across Fortune ... already secured over 15 million users across the financial ... connected home product suites and physical access represent a ...
(Date:4/4/2017)... NEW YORK , April 4, 2017   ... solutions, today announced that the United States Patent and ... The patent broadly covers the linking of an iris ... the same transaction) and represents the company,s 45 th ... our latest patent is very timely given the multi-modal ...
(Date:3/30/2017)... 30, 2017  On April 6-7, 2017, Sequencing.com will ... hackathon at Microsoft,s headquarters in ... focus on developing health and wellness apps that provide ... the Genome is the first hackathon for personal ... largest companies in the genomics, tech and health industries ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... AMRI, a global contract research, ... improve patient outcomes and quality of life, will now be offering its impurity ... to new regulatory requirements for all new drug products, including the finalization of ...
(Date:10/11/2017)... ... October 11, 2017 , ... ... in its endogenous context, enabling overexpression experiments and avoiding the use of exogenous ... RNA guides is transformative for performing systematic gain-of-function studies. , This complement ...
(Date:10/11/2017)... ... October 11, 2017 , ... ... today it will be hosting a Webinar titled, “Pathology is going digital. Is ... , on digital pathology adoption best practices and how Proscia improves lab economics ...
(Date:10/11/2017)... ... October 11, 2017 , ... Disappearing forests and increased emissions are the ... million people each year. Especially those living in larger cities are affected by air ... one of the most pollution-affected countries globally - decided to take action. , “I ...
Breaking Biology Technology: