Navigation Links
Stem cell study opens door to undiscovered world of biology
Date:3/9/2014

author of the study, realized that this reagent could be adapted to measure new protein synthesis by stem cells and other cells in the blood-forming system.

What they came across was astonishing, Dr. Morrison said. The findings suggested that different types of blood cells produce vastly different amounts of protein per hour, and stem cells in particular synthesize much less protein than any other blood-forming cells.

"This result suggests that blood-forming stem cells require a lower rate of protein synthesis as compared to other blood-forming cells," said Dr. Morrison, the paper's senior author.

Researchers applied the findings to a mouse model with a genetic mutation in a component of the ribosome the machinery that makes proteins and the rate of protein production was reduced in stem cells by 30 percent. The scientists also increased the rate of protein synthesis by deleting the tumor suppressor gene Pten in blood-forming stem cells. In both instances, stem cell function was noticeably impaired.

Together, these observations demonstrate that blood-forming stem cells require a highly regulated rate of protein synthesis, such that increases or decreases in that rate impair stem cell function.

"Amazingly, when the ribosomal mutant mice and the Pten mutant mice were bred together, stem cell function returned to normal, and we greatly delayed, and in some instances entirely blocked, the development of leukemia," Dr. Morrison said. "All of this happened because protein production in stem cells was returned to normal. It was as if two wrongs made a right."

Many diseases, including degenerative diseases and certain types of cancers, are associated with mutations in the machinery that makes proteins. However, why this is the case has yet to be understood. Discoveries such as this raise the possibility that changes in protein synthesis are necessary for the development of those diseases.

"
'/>"/>

Contact: Lisa Warshaw
lisa.warshaw@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
2. Law that regulates shark fishery is too liberal: UBC study
3. New study will help protect vulnerable birds from impacts of climate change
4. Study jointly led by UCSB researcher supports theory of extraterrestrial impact
5. BYU study: Using a gun in bear encounters doesnt make you safer
6. 15-year study: When it comes to creating wetlands, Mother Nature is in charge
7. Pycnogenol (French maritime pine bark extract) shown to improve menopause symptoms in new study
8. Crystal structure of archael chromatin clarified in new study
9. EU-funded study underlines importance of Congo Basin for global climate and biodiversity
10. University of Houston study shows BP oil spill hurt marshes, but recovery possible
11. Study demonstrates cells can acquire new functions through transcriptional regulatory network
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Stem cell study opens door to undiscovered world of biology
(Date:6/26/2015)... , June 26, 2015 ATL Technology, LLC, ... devices with specialties in single use solutions, headquartered in ... MedConx, Inc. (a California corporation with ... San Jose, Costa Rica ). ... Costa Rica with ATL Technology,s existing facility in ...
(Date:6/24/2015)... 2015 This report provides market analysis of ... years. It contains an analysis of the drivers, challenges, ... impact from the short, medium, and long term perspective ... market, and technology trends that currently, prevail in the ... authorities to efficiently manage the increasing marine traffic and ...
(Date:6/23/2015)... 2015 Research and ... the "Body-Worn Temperature Sensors Market - Global ... 2014 - 2020" report to their offering. ... the global body-worn temperature sensors market. The global ... the basis of types, care setting, patient demographic, ...
Breaking Biology News(10 mins):ATL Technology Announces Acquisition of MedConx, Inc. and Expanded Global Footprint 2Automatic Identification System Market by Class, by Platform, by Application and by Geography - Global Forecasts & Analysis to 2014 - 2020 2Body-Worn Temperature Sensors Market - Global Industry Analysis 2
... #1 FOR IMMEDIATE RELEASE Identifying abnormal protein ... Research Researchers in Massachusetts are reporting an ... the biochemical changes that occur inside the eyes of ... of vision loss and blindness in adults. In a ...
... already for its role in schizophrenia has been ... a report in todays advance on-line issue of Nature. ... Center (BIDMC), the study further suggests that a steroid ... and therapeutic supplement for the treatment of this dangerous ...
... straightforward migration to EAC ePassport technology, DALLAS, ... Inc. (Nasdaq: ENTU ) will provide its ... help authenticate sensitive,biometric information stored on machine readable ... which will be available to nearly 23 million,citizens ...
Cached Biology News:American Chemical Society’s Weekly PressPac -- May 7, 2008 2American Chemical Society’s Weekly PressPac -- May 7, 2008 3American Chemical Society’s Weekly PressPac -- May 7, 2008 4American Chemical Society’s Weekly PressPac -- May 7, 2008 5American Chemical Society’s Weekly PressPac -- May 7, 2008 6American Chemical Society’s Weekly PressPac -- May 7, 2008 7American Chemical Society’s Weekly PressPac -- May 7, 2008 8A new gene trigger for pregnancy disorder identified 2Entrust, Hewlett Packard Partner to Deploy Taiwanese ePassports, Authenticate Biometric Data 2Entrust, Hewlett Packard Partner to Deploy Taiwanese ePassports, Authenticate Biometric Data 3
(Date:7/1/2015)... ... July 01, 2015 , ... NEMA 4 (IP66) ... CTI’ new Medical Joysticks have an impermeable molecular barrier protection against bio-hazardous agents. ... device that will increase healthcare worker safety and reduce financial costs. , CTI ...
(Date:6/30/2015)... Japan , July 1, 2015 R-Japan Co.,Ltd. ... on the Safety of Regenerative Medicine from the Ministry of ... on June 29, 2015. The fact that ... processing facility through the auditing from Pharmaceuticals and Medical Devices ... the application, allows it to provide stem cell manufacturing service ...
(Date:6/30/2015)... /PRNewswire/ - Resverlogix Corp. ("Resverlogix") (TSX:RVX) announced today ... have approved the resolutions relating to: (i) a ... units at a price of $2.67 per unit ... of one common share and 0.075358 common share ... million; and (ii) the amendment to Resverlogix,s articles ...
(Date:6/30/2015)... , June 30, 2015  NASA astronaut Kjell Lindgren ... month on his first mission to the International Space ... 8 to 9 a.m. EDT Tuesday, July 7. ... Star City, Russia . The interviews will ... Television highlighting his mission training. To schedule an ...
Breaking Biology Technology:Sanitized Medical Joysticks for a Safer and Healthier Work Environment 2R-Japan Obtained Autologous Stem Cell Manufacturing License from the Ministry of Health, Labour and Welfare 2Resverlogix Corp. Shareholders Approve Matters Relating to Licensing and Equity Arrangement 2Resverlogix Corp. Shareholders Approve Matters Relating to Licensing and Equity Arrangement 3NASA Astronaut Preps for First Space Station Mission, Available for Media Interviews 2
... MADISON If you asked Wisconsin citizens what they ... the past year or so, the answers would likely ... bills dealing with religion, concealed weapons and same-sex marriage. ... so-called three Gs werent the biggest story of the ...
... , based in Green Bay, has announced a ... reach out to creative agencies and their clients. , ... designers, project managers and clients. It is intended as ... documents and files, the company said. , ,"Typically, Inspire ...
... of PR account executives when one woman asked a question that ... my opinion on the proliferation of mobile devices, she asked if ... question a lot, in one form or another, but on this ... the very earliest days of a new age of computing, I ...
Cached Biology Technology:Despite the three Gs, the Wisconsin Legislature had a productive session 2Despite the three Gs, the Wisconsin Legislature had a productive session 3Wisconsin startup delivers project management relief to creative firms and ad agencies 2The age of human computing? 2The age of human computing? 3
... 384 is a compact and self-contained ... is a unique flow-through device, which ... included wash system. Optional refill ... system. Will be upgradable to ...
... Eclipse C1 Plus is a modular confocal ... imaging with an ultra-compact and lightweight design. ... C1 Plusboost optical performance to 400nm andits ... alsoincludes support for X and Y scan ...
This kit is designed to select cells labeled with phycoerythrin- (PE-) conjugated antibodies. Kit includes reagents for labeling 3 x 10 9 cells and EasySep magnet....
... Motic's amazing new range of ergonomic ... and with a small footprint. The DM-BA200 ... Optical System and an exchangeable USB2.0 plug ... infinity-corrected E-Plan Achromat objectives mounted on a ...
Biology Products: