Navigation Links
Stem cell source an important factor, impacting ability to treat myocardial infarction
Date:2/13/2013

Putnam Valley, NY. (Feb. 13, 2013) When a research team from Denmark and Sweden compared the therapeutic capabilities of adipose-derived stem cells (ASCs) versus bone marrow-derived stem cells (BMSCs) obtained from a single 84 year-old male donor with ischemic coronary disease to regeneratively treat myocardial infarction in a rat model, they found that the ASCs preserved more cardiac function in the test rats while neither stem cell type induced myocardial angiogenesis (blood vessel growth.)

The study appears as an early e-publication for the journal Cell Transplantation, and is now freely available on-line at http://www.ingentaconnect.com/content/cog/ct/pre-prints/ct0921rasmussen.

"Treatment of myocardial infarction with bone marrow-derived mesenchymal stem cells (BM-MSCs) and adipose-derived stem cells has shown promising results," said study co-author Dr. Trine Fink. "The transplantation of MSCs in treating myocardial infarction (MI) has been shown to improve left ventricular function in animal models. In this study, we compared the effects of adipose-derived stem cells and BMSCs from an elderly male suffering from coronary atherosclerosis when the donated cells were transplanted randomly, without the administration of immunosuppressant drugs, into two groups of adult rats modeled with MI."

The researchers noted that the age and health status of cell donors are important factors and that the impact of cell transplantation using cells from elderly patients with cardiac ischemia "needs to be elucidated."

The researchers found that ASCs ameliorated heart failure following MI in the group receiving ASCs while the group receiving the BMSCs received no similar benefit. They found that the BMSCs secreted a significantly larger amount of vascular endothelial growth factor, VEGF, than the ASCs, but that did not result in a better angiogenic response. In addition, the group receiving ASCs had improved left ventricular fraction.

That neither stem cell group induced myocardial angiogenesis raised questions about whether donor age and health have an effect on the efficacy of stem cells used in treating myocardial infarction, said the researchers.

"While this study supported previous findings that ASCs are less prone to diminish in numbers and efficacy with aging when compared to BMSCs, the characteristics of MSCs from elderly patients suffering from coronary atherosclerosis need to be determined," they concluded.


'/>"/>

Contact: Robert Miranda
cogcomm@aol.com
Cell Transplantation Center of Excellence for Aging and Brain Repair
Source:Eurekalert

Related biology news :

1. Hastings Center resources chart progress in debate over medical research with animals
2. Nitrogen from pollution, natural sources causes growth of toxic algae, study finds
3. Marginal lands are prime fuel source for alternative energy
4. Elsevier launches new journal: Journal of Unconventional Oil and Gas Resources
5. The first genome sequence of Chinese plum provides important resource for fruit improvement
6. Soybeans a source of valuable chemical
7. Lyncean Technologies Inc. sells Compact Light Source to Munich biomedical-imaging research center
8. New test adds to scientists understanding of Earths history, resources
9. Stanford geoscientist cites critical need for basic research to unleash promising energy sources
10. Study IDs kerosene lamps as big source of black carbon
11. Water resources management and policy in a changing world: Where do we go from here?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/15/2016)... 2016 --> --> ... Market Research "Digital Door Lock Systems Market - Global Industry ... the global digital door lock systems market in terms of ... is forecast to grow at a CAGR of 31.8% during ... medium enterprises (MSMEs) across the world and high industrial activity ...
(Date:3/14/2016)... Allemagne, March 14, 2016 ... - --> - Renvoi : image disponible ... --> --> DERMALOG, ... fournit de nouveaux lecteurs d,empreintes digitales pour l,enregistrement ... DERMALOG sera utilisé pour produire des cartes d,identité ...
(Date:3/10/2016)... 2016 --> ... "Identity and Access Management Market by Component (Provisioning, Directory ... by Organization Size, by Deployment, by Vertical, and by ... The market is estimated to grow from USD 7.20 ... at a Compound Annual Growth Rate (CAGR) of 12.2% ...
Breaking Biology News(10 mins):
(Date:5/23/2016)... Oxitec CEO Hadyn Parry will testify ... before the United States House Committee on Science, Space and ... controlling the spread of the Aedes aegypti mosquito, ... (Logo: http://photos.prnewswire.com/prnh/20150630/227348 ) Oxitec has pioneered ... in Brazil , Panama ...
(Date:5/20/2016)... ... May 20, 2016 , ... The leading Regenerative Veterinary Medicine Company, ... clients have treated over 100 of their own patients with the VetStem Cell Therapy. ... level of care for their patients. , The veterinarians are Dr Ross Rich ...
(Date:5/19/2016)... , May 19, 2016  AdvancedFlow Systems ... Inc. (AGI), based out of Maple ... Biogas Ltd. to its existing portfolio of contract ... agreement. AFS along with its sister companies Surround ... a vertically integrated industrial group that specializes in ...
(Date:5/18/2016)... ... May 18, 2016 , ... Tech Coast Angels (TCA) today ... Cognition Therapeutics at the annual ACA Summit last week in Philadelphia. , ... of ACA’s member angel groups. It is the highest honor available for an early-stage ...
Breaking Biology Technology: