Navigation Links
Stem cell source an important factor, impacting ability to treat myocardial infarction
Date:2/13/2013

Putnam Valley, NY. (Feb. 13, 2013) When a research team from Denmark and Sweden compared the therapeutic capabilities of adipose-derived stem cells (ASCs) versus bone marrow-derived stem cells (BMSCs) obtained from a single 84 year-old male donor with ischemic coronary disease to regeneratively treat myocardial infarction in a rat model, they found that the ASCs preserved more cardiac function in the test rats while neither stem cell type induced myocardial angiogenesis (blood vessel growth.)

The study appears as an early e-publication for the journal Cell Transplantation, and is now freely available on-line at http://www.ingentaconnect.com/content/cog/ct/pre-prints/ct0921rasmussen.

"Treatment of myocardial infarction with bone marrow-derived mesenchymal stem cells (BM-MSCs) and adipose-derived stem cells has shown promising results," said study co-author Dr. Trine Fink. "The transplantation of MSCs in treating myocardial infarction (MI) has been shown to improve left ventricular function in animal models. In this study, we compared the effects of adipose-derived stem cells and BMSCs from an elderly male suffering from coronary atherosclerosis when the donated cells were transplanted randomly, without the administration of immunosuppressant drugs, into two groups of adult rats modeled with MI."

The researchers noted that the age and health status of cell donors are important factors and that the impact of cell transplantation using cells from elderly patients with cardiac ischemia "needs to be elucidated."

The researchers found that ASCs ameliorated heart failure following MI in the group receiving ASCs while the group receiving the BMSCs received no similar benefit. They found that the BMSCs secreted a significantly larger amount of vascular endothelial growth factor, VEGF, than the ASCs, but that did not result in a better angiogenic response. In addition, the group receiving ASCs had improved left ventricular fraction.

That neither stem cell group induced myocardial angiogenesis raised questions about whether donor age and health have an effect on the efficacy of stem cells used in treating myocardial infarction, said the researchers.

"While this study supported previous findings that ASCs are less prone to diminish in numbers and efficacy with aging when compared to BMSCs, the characteristics of MSCs from elderly patients suffering from coronary atherosclerosis need to be determined," they concluded.


'/>"/>

Contact: Robert Miranda
cogcomm@aol.com
Cell Transplantation Center of Excellence for Aging and Brain Repair
Source:Eurekalert

Related biology news :

1. Hastings Center resources chart progress in debate over medical research with animals
2. Nitrogen from pollution, natural sources causes growth of toxic algae, study finds
3. Marginal lands are prime fuel source for alternative energy
4. Elsevier launches new journal: Journal of Unconventional Oil and Gas Resources
5. The first genome sequence of Chinese plum provides important resource for fruit improvement
6. Soybeans a source of valuable chemical
7. Lyncean Technologies Inc. sells Compact Light Source to Munich biomedical-imaging research center
8. New test adds to scientists understanding of Earths history, resources
9. Stanford geoscientist cites critical need for basic research to unleash promising energy sources
10. Study IDs kerosene lamps as big source of black carbon
11. Water resources management and policy in a changing world: Where do we go from here?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/19/2017)... York , April 19, 2017 ... as its vendor landscape is marked by the presence ... market is however held by five major players - ... Together these companies accounted for nearly 61% of the ... the leading companies in the global military biometrics market ...
(Date:4/13/2017)... 2017 UBM,s Advanced Design and Manufacturing event ... emerging and evolving technology through its 3D Printing and ... alongside the expo portion of the event and feature ... focused on trending topics within 3D printing and smart ... event will take place June 13-15, 2017 at the Jacob ...
(Date:4/11/2017)... DUBLIN , Apr. 11, 2017 Research ... Tracking Market 2017-2021" report to their offering. ... The global eye tracking market to grow at ... The report, Global Eye Tracking Market 2017-2021, has been prepared based ... report covers the market landscape and its growth prospects over the ...
Breaking Biology News(10 mins):
(Date:6/20/2017)... ... June 20, 2017 , ... ... the adulterants which pose the most likely threat to their products at the ... year. , IFT's annual food expo attracts over 20,000 attendees representing food ...
(Date:6/19/2017)... ... June 19, 2017 , ... As Vice President, ... products including training, implementation, support, and client process and SOP development. , Mr. ... previously held leadership roles for service providers and top-tier pharmaceuticals, and as an ...
(Date:6/16/2017)... ... 16, 2017 , ... Cambridge Semantics , the leading ... Smart Data Lake® (Anzo SDL) solution was named a finalist in the ... Information Industry Association (SIIA) CODiE Awards. , Finalists represent the best products, ...
(Date:6/15/2017)... , ... June 15, 2017 , ... ... a promising new medical device startup. Dan Parsley, angelMD’s SVP of Corporate Development, ... members, and this angelMD syndicate is part of Saranas’ recently announced $4 million ...
Breaking Biology Technology: