Navigation Links
Stem cell research provides hope for infertile cancer survivors
Date:12/10/2012

Radiation and chemotherapy can pack a powerful punch against all kinds of cancers. Those who survive, however, are often left with bad news: Their treatments have rendered them infertile.

A UTSA professor has now demonstrated that it is possible to remove testicular stem cells from a monkey prior to chemotherapy, freeze them and later, after cancer treatments, transplant these cells where they can restart sperm production and restore fertility.

UTSA Assistant Professor Brian Hermann worked in collaboration with researchers at the University of Pittsburgh School of Medicine's Magee-Womens Research Institute (MWRI) on a technique that might be used to make male cancer patients fertile using their own spermatogonial stem cells.

"This is a really exciting milestone for this research," said John McCarrey, director of the San Antonio Cellular Therapeutics Institute. "This is the first time that anybody has been able to show the concept works in a primate model, and that is an important step in moving the research forward to clinical trials."

While men facing cancer treatments, which could cause infertility, are able to store their own sperm for future use in the fertility clinic, this is not an option for boys before puberty who are not yet making sperm. But, all prepubertal boys have spermatogonial stem cells (SSCs) in their testes, which could be used for transplantation.

The concept of using spermatogonial stem cells to restore fertility was first introduced in the mid-1990s by University of Pennsylvania scholar Ralph L. Brinster. Since that time, scholars have been working to demonstrate the concept is viable.

But more work is required.

The research must overcome a number of hurdles before it can become a common clinical practice.

"This research demonstrates the proof of principle that the concept works in primates and has a good chance of working in humans," said Hermann. "We need to better understand the optimal timing of transplantation, how to prepare testicular stem cells for transplantation and make them safe for transplantation, and how to maximize their ability to restart sperm production."

But it's hard for researchers to know when clinical trials will begin since the removal and storage of spermatogonial stem cells is currently a rare practice worldwide.

"There are currently only a handful of clinics around the world that will remove and preserve testicular stem cell samples from prepubertal patients, and that limits the availability of candidates," said Hermann. "Until more clinics get on board and save stem cells for patients, we are limited in what we can do to test transplantation in clinical trials."

Hermann joined the UTSA College of Sciences' faculty in summer 2011, following a post-doctoral fellowship at MWRI alongside Associate Professor Kyle Orwig. At UTSA, he is continuing to focus his research on basic and translational studies of spermatogonial stem cells to preserve fertility in boys treated for cancer and related diseases.

"For a long time, oncologists have been unable to address the long-term consequences of life-saving chemotherapy and radiation treatments such as infertility," said Hermann. "That is now beginning to change as laboratory research such as this study provides new experimental options for patients facing infertility after cancer."


'/>"/>

Contact: Christi Fish
christi.fish@utsa.edu
210-458-5141
University of Texas at San Antonio
Source:Eurekalert

Related biology news :

1. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
2. Research reveals first evidence of hunting by prehistoric Ohioans
3. Diabetes Research Institute develops oxygen-generating biomaterial
4. APS issues new policy requiring identification of sex or gender in reporting scientific research
5. UC Santa Barbara researchers discover genetic link between visual pathways of hydras and humans
6. Study jointly led by UCSB researcher supports theory of extraterrestrial impact
7. U of Alberta researcher steps closer to understand autoimmune diseases
8. Research on flavanols and procyanidins provides new insights into how these phytonutrients may positively impact human health
9. A project to research biological and chemical aspects of microalgae to fuel approach
10. Scripps Research discoveries lead to newly approved drug for infant respiratory distress syndrome
11. Researchers attempt to solve problems of antibiotic resistance and bee deaths in one
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/26/2017)... , Jan. 26, 2017  Crossmatch, a leading ... a new solution aimed at combatting fraud, waste and ... was introduced at the Action on Disaster Relief conference ... meeting point for UN agencies and foreign assistance organizations ... Fraud, waste and abuse are a largely unacknowledged problem ...
(Date:1/24/2017)...  It sounds simple and harmless—an electronic sensor ... signs and alerts parents on their smart phones ... drops. But pediatric experts argue that such devices ... evidence of medical benefits, especially to healthy babies. ... parents of healthy babies, promising peace of mind ...
(Date:1/19/2017)... , Jan. 19, 2017 Sensory ... experience and security for consumer electronics, and ... processing systems and cybersecurity solutions, today announced a ... and financial institutions worldwide to bolster security of ... end-to-end secure user authentication platforms they offer, innerCore ...
Breaking Biology News(10 mins):
(Date:2/16/2017)... Feb. 16, 2017  Rhythm, a biopharmaceutical ... deficiencies that result in life-threatening metabolic disorders, ... million mezzanine round of financing with existing ... Capital, New Enterprise Associates, Pfizer Venture Investments, ... healthcare investment fund. Rhythm will use the ...
(Date:2/16/2017)... Indiana (PRWEB) , ... February ... ... of Albany Molecular Research Inc. has further extended its industry leading Biochemistry ... This service offers state-of-the-art cGMP techniques and methods for the biochemical ...
(Date:2/15/2017)... Clara, CA (PRWEB) , ... February 15, 2017 , ... ... announced that Park SmartScan, a powerful AFM operating software that drastically boosts productivity with ... SmartScan completely automatizes all of the functions of setting up and taking the image ...
(Date:2/15/2017)... WASHINGTON , Feb. 15, 2017  NASA provider ... Services mission to the  International Space Station  no earlier ... of the launch will begin at 8:30 a.m. on ... SpaceX Dragon spacecraft will lift off on ... at NASA,s Kennedy Space Center ...
Breaking Biology Technology: