Navigation Links
Stem cell research provides hope for infertile cancer survivors
Date:12/10/2012

Radiation and chemotherapy can pack a powerful punch against all kinds of cancers. Those who survive, however, are often left with bad news: Their treatments have rendered them infertile.

A UTSA professor has now demonstrated that it is possible to remove testicular stem cells from a monkey prior to chemotherapy, freeze them and later, after cancer treatments, transplant these cells where they can restart sperm production and restore fertility.

UTSA Assistant Professor Brian Hermann worked in collaboration with researchers at the University of Pittsburgh School of Medicine's Magee-Womens Research Institute (MWRI) on a technique that might be used to make male cancer patients fertile using their own spermatogonial stem cells.

"This is a really exciting milestone for this research," said John McCarrey, director of the San Antonio Cellular Therapeutics Institute. "This is the first time that anybody has been able to show the concept works in a primate model, and that is an important step in moving the research forward to clinical trials."

While men facing cancer treatments, which could cause infertility, are able to store their own sperm for future use in the fertility clinic, this is not an option for boys before puberty who are not yet making sperm. But, all prepubertal boys have spermatogonial stem cells (SSCs) in their testes, which could be used for transplantation.

The concept of using spermatogonial stem cells to restore fertility was first introduced in the mid-1990s by University of Pennsylvania scholar Ralph L. Brinster. Since that time, scholars have been working to demonstrate the concept is viable.

But more work is required.

The research must overcome a number of hurdles before it can become a common clinical practice.

"This research demonstrates the proof of principle that the concept works in primates and has a good chance of working in humans," said Hermann. "We need to better understand the optimal timing of transplantation, how to prepare testicular stem cells for transplantation and make them safe for transplantation, and how to maximize their ability to restart sperm production."

But it's hard for researchers to know when clinical trials will begin since the removal and storage of spermatogonial stem cells is currently a rare practice worldwide.

"There are currently only a handful of clinics around the world that will remove and preserve testicular stem cell samples from prepubertal patients, and that limits the availability of candidates," said Hermann. "Until more clinics get on board and save stem cells for patients, we are limited in what we can do to test transplantation in clinical trials."

Hermann joined the UTSA College of Sciences' faculty in summer 2011, following a post-doctoral fellowship at MWRI alongside Associate Professor Kyle Orwig. At UTSA, he is continuing to focus his research on basic and translational studies of spermatogonial stem cells to preserve fertility in boys treated for cancer and related diseases.

"For a long time, oncologists have been unable to address the long-term consequences of life-saving chemotherapy and radiation treatments such as infertility," said Hermann. "That is now beginning to change as laboratory research such as this study provides new experimental options for patients facing infertility after cancer."


'/>"/>

Contact: Christi Fish
christi.fish@utsa.edu
210-458-5141
University of Texas at San Antonio
Source:Eurekalert

Related biology news :

1. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
2. Research reveals first evidence of hunting by prehistoric Ohioans
3. Diabetes Research Institute develops oxygen-generating biomaterial
4. APS issues new policy requiring identification of sex or gender in reporting scientific research
5. UC Santa Barbara researchers discover genetic link between visual pathways of hydras and humans
6. Study jointly led by UCSB researcher supports theory of extraterrestrial impact
7. U of Alberta researcher steps closer to understand autoimmune diseases
8. Research on flavanols and procyanidins provides new insights into how these phytonutrients may positively impact human health
9. A project to research biological and chemical aspects of microalgae to fuel approach
10. Scripps Research discoveries lead to newly approved drug for infant respiratory distress syndrome
11. Researchers attempt to solve problems of antibiotic resistance and bee deaths in one
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2016)... 2016 http://www.researchandmarkets.com/research/p74whf/global_biometrics ... "Global Biometrics Market in Retail Sector ... --> http://www.researchandmarkets.com/research/p74whf/global_biometrics ) has announced ... Market in Retail Sector 2016-2020" report ... Research and Markets ( http://www.researchandmarkets.com/research/p74whf/global_biometrics ) has ...
(Date:1/20/2016)... , Jan. 20, 2016   MedNet Solutions , ... entire spectrum of clinical research, is pleased to announce ... significant achievements are the result of the company,s laser ... iMedNet eClinical , it,s comprehensive, easy-to-use and highly ... --> Key MedNet growth achievements in 2015 ...
(Date:1/15/2016)... SAN JUAN, Puerto Rico , Jan. 15, 2016 ... forcing companies big and small to find new ways ... data driven culture. iOS and ... their device based on biometrics, transforming it into a ... can request that users swipe their fingerprint on their ...
Breaking Biology News(10 mins):
(Date:2/11/2016)... ... February 11, 2016 , ... Global ... treatment clinic in Quito, Ecuador. The new facility will provide advanced protocols and ... from around the world. , The new GSCG clinic is headed by ...
(Date:2/10/2016)... 2016 ASAE is introducing a hybrid membership ... (AMC) the option of joining or renewing through an ... by staff size, every employee in any size association ... reap all available member benefits.   John ... membership options will allow organizations of any size and ...
(Date:2/10/2016)... ... 2016 , ... Benchmark Research, a fully-integrated network of ... principal investigators (PI) to the roles of Chief Medical Officer, Clinical Research and ... Chu, a Benchmark Research PI in the Austin office, will assume the role ...
(Date:2/10/2016)... ... February 10, 2016 , ... Curoverse announced today that the ... provides capabilities for managing and processing genomic and health data at petabyte scale. ... collecting and analyzing genomic data,” said Adam Berrey chief executive officer at Curoverse. ...
Breaking Biology Technology: