Navigation Links
Stem cell research provides hope for infertile cancer survivors
Date:12/10/2012

Radiation and chemotherapy can pack a powerful punch against all kinds of cancers. Those who survive, however, are often left with bad news: Their treatments have rendered them infertile.

A UTSA professor has now demonstrated that it is possible to remove testicular stem cells from a monkey prior to chemotherapy, freeze them and later, after cancer treatments, transplant these cells where they can restart sperm production and restore fertility.

UTSA Assistant Professor Brian Hermann worked in collaboration with researchers at the University of Pittsburgh School of Medicine's Magee-Womens Research Institute (MWRI) on a technique that might be used to make male cancer patients fertile using their own spermatogonial stem cells.

"This is a really exciting milestone for this research," said John McCarrey, director of the San Antonio Cellular Therapeutics Institute. "This is the first time that anybody has been able to show the concept works in a primate model, and that is an important step in moving the research forward to clinical trials."

While men facing cancer treatments, which could cause infertility, are able to store their own sperm for future use in the fertility clinic, this is not an option for boys before puberty who are not yet making sperm. But, all prepubertal boys have spermatogonial stem cells (SSCs) in their testes, which could be used for transplantation.

The concept of using spermatogonial stem cells to restore fertility was first introduced in the mid-1990s by University of Pennsylvania scholar Ralph L. Brinster. Since that time, scholars have been working to demonstrate the concept is viable.

But more work is required.

The research must overcome a number of hurdles before it can become a common clinical practice.

"This research demonstrates the proof of principle that the concept works in primates and has a good chance of working in humans," said Hermann. "We need to bett
'/>"/>

Contact: Christi Fish
christi.fish@utsa.edu
210-458-5141
University of Texas at San Antonio
Source:Eurekalert

Page: 1 2

Related biology news :

1. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
2. Research reveals first evidence of hunting by prehistoric Ohioans
3. Diabetes Research Institute develops oxygen-generating biomaterial
4. APS issues new policy requiring identification of sex or gender in reporting scientific research
5. UC Santa Barbara researchers discover genetic link between visual pathways of hydras and humans
6. Study jointly led by UCSB researcher supports theory of extraterrestrial impact
7. U of Alberta researcher steps closer to understand autoimmune diseases
8. Research on flavanols and procyanidins provides new insights into how these phytonutrients may positively impact human health
9. A project to research biological and chemical aspects of microalgae to fuel approach
10. Scripps Research discoveries lead to newly approved drug for infant respiratory distress syndrome
11. Researchers attempt to solve problems of antibiotic resistance and bee deaths in one
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2014)... August 21, 2014 Diabetes affects nearly 10 ... complaints of diabetics: constant finger pricking to test ... Chemical Biology reports the development of a protein ... accurate results for diabetes patients. In the American ... Daunert, Ph.D., shows off her "designer protein" that ...
(Date:8/22/2014)... discoveries in basic and clinical research and technological ... a complex offensive spanning multiple fronts. , Work ... could help find new and more selective therapies ... targets a specific enzyme overexpressed in certain cancersand ... brain tumours. , Chemistry professor Christopher Cairo and ...
(Date:8/22/2014)... antioxidants and can reduce free radical damage. ... oxidative stress? Jianbo Zhao and co-workers from ... University, China discovered that green tea polyphenol ... apoptosis, indicating green tea polyphenols play a ... oxidative stress. The relevant study has been ...
Breaking Biology News(10 mins):New enzyme targets for selective cancer therapies 2New enzyme targets for selective cancer therapies 3
... the challenges for forests and the costs of ... factors surrounding biofuel crop production and its implications ... Sustainability Reports. Produced by the Ecological Society of ... scientists, and sponsored by the Energy Foundation, these ...
... University] Scientists have long known that the brain,s ... how the brain processes more complex and unfamiliar knowledge. ... in the journal Neuron , a team of ... tested whether the frontal lobe has the ability to ...
... largest fresh-water floods in Earth,s history happened about 17,000 years ... now occupied in part by the city of Wasilla, widely ... was one of at least four "megafloods" as Glacial Lake ... more than 3,500 square miles in the Copper River Basin ...
Cached Biology News:Sustainable biofuels from forests, grasslands and rangelands 2Sustainable biofuels from forests, grasslands and rangelands 3Complex brain functions help adapt to new situations and stimuli 2Research shows part of Alaska inundated by ancient megafloods 2Research shows part of Alaska inundated by ancient megafloods 3
(Date:8/21/2014)... Dallas, Texas (PRWEB) August 21, 2014 ... Global Seaweed Fertilizer Industry” is a professional ... Fertilizer market. The report provides basic Seaweed ... application, and industry chain structure as well ... international market analysis, including domestic market as ...
(Date:8/21/2014)... N.Y. (PRWEB) August 21, 2014 The ... the first private college in the Mid-Hudson Region to ... will now begin accepting applications from qualified “high-technology” businesses ... “We are very pleased to have been selected for ... Governor Cuomo’s transformative initiative to stimulate economic development in ...
(Date:8/21/2014)... Cord Blood Corporation (NYSE: CO ) (the ... for the first quarter of fiscal year 2015 on ... US.  The Company will host a ... 29, 2014 to discuss its financial performance and give ... by a question and answer session.  Interested parties may ...
(Date:8/21/2014)... MO (PRWEB) August 21, 2014 ... service biopharmaceutical contract development and manufacturing organization (CMO) ... Progenics Pharmaceuticals, Inc., an oncology company focused on ... treating cancer, to manufacture the anti-prostate specific membrane ... ADC product candidate. Under the agreement the ...
Breaking Biology Technology:Internationals Seaweed Fertilizer Industry 2014 Development Trend Analysis in New Research Study at DeepResearchReports.com 2Internationals Seaweed Fertilizer Industry 2014 Development Trend Analysis in New Research Study at DeepResearchReports.com 3The College of New Rochelle Becomes First Private College in Mid-Hudson Region to Earn START-UP NY Designation 2The College of New Rochelle Becomes First Private College in Mid-Hudson Region to Earn START-UP NY Designation 3China Cord Blood Corporation to Report First Quarter of Fiscal 2015 Financial Results 2Gallus Enters Agreement with Progenics Pharmaceuticals, Inc. for Manufacture of Anti-PSMA Monoclonal Antibody 2Gallus Enters Agreement with Progenics Pharmaceuticals, Inc. for Manufacture of Anti-PSMA Monoclonal Antibody 3
... the second time this year, a tech-based company in Wisconsin ... the public. Called an initial public offering, this kind of ... investors who are directly involved, but to others who may ... biotechnology company, has filed papers with the Securities and ...
... as are demands for the CIO's attention: electronic health ... and the like, combined with the standard fare of ... , ,The C-suite also is going through a major ... is that ability to execute corporate strategy, rather than ...
... Wis. - With the goal of transforming more ... Wisconsin-Madison has approved a new research entity - ... institute is a collaboration of the four UW-Madison health ... Veterinary Medicine. It will partner with the Marshfield Clinic ...
Cached Biology Technology:Wisconsin IPOs are a harbinger of growing tech economy 2Wisconsin IPOs are a harbinger of growing tech economy 3Fire your CIO? If he's not implementing strategy, show him the door 2Fire your CIO? If he's not implementing strategy, show him the door 3
...
Improve inventory management with stainless steel red cell canisters; ensure product safety with CO2 or LN2 backup systems. A complete solution for your blood banking needs....
... oligonucleotides: PTOs are internucleotide modifications, ... backbone is replaced by a sulphur atom. ... degradation. PTOs are available as ... Oligonucleotides with thio-caps ...
Improve inventory management with stainless steel red cell canisters; ensure product safety with CO2 or LN2 backup systems. A complete solution for your blood banking needs....
Biology Products: