Navigation Links
Stem cell research helps to identify origins of schizophrenia
Date:1/22/2013

BUFFALO, N.Y. New University at Buffalo research demonstrates how defects in an important neurological pathway in early development may be responsible for the onset of schizophrenia later in life.

The UB findings, published in Schizophrenia Research (paper at http://bit.ly/Wq1i41), test the hypothesis in a new mouse model of schizophrenia that demonstrates how gestational brain changes cause behavioral problems later in life just like the human disease.

Partial funding for the research came from New York Stem Cell Science (NYSTEM).

The genomic pathway, called the Integrative Nuclear FGFR 1 Signaling (INFS), is a central intersection point for multiple pathways of as many as 160 different genes believed to be involved in the disorder.

"We believe this is the first model that explains schizophrenia from genes to development to brain structure and finally to behavior," says lead author Michal Stachowiak, PhD, professor in the Department of Pathology and Anatomical Sciences in the UB School of Medicine and Biomedical Sciences. He also is director of the Stem Cell Engraftment & In Vivo Analysis Facility at the Western New York Stem Cell Culture and Analysis Center at UB.

A key challenge with the disease is that patients with schizophrenia exhibit mutations in different genes, he says.

"How is it possible to have 100 patients with schizophrenia and each one has a different genetic mutation that causes the disorder?" asks Stachowiak. "It's possible because INFS integrates diverse neurological signals that control the development of embryonic stem cell and neural progenitor cells, and links pathways involving schizophrenia-linked genes.

"INFS functions like the conductor of an orchestra," explains Stachowiak. "It doesn't matter which musician is playing the wrong note, it brings down the conductor and the whole orchestra. With INFS, we propo
'/>"/>

Contact: Ellen Goldbaum
goldbaum@buffalo.edu
716-645-4605
University at Buffalo
Source:Eurekalert  

Page: 1 2

Related biology news :

1. UT Dallas researchers awarded $4.3 million to create next-generation technologies
2. Vitamin D holds promise in battling a deadly breast cancer, Saint Louis University researchers say
3. Men more likely to commit research misconduct than female counterparts
4. Researchers analyse rock dissolving method of geoengineering
5. Researchers show how cells DNA repair machinery can destroy viruses
6. Researchers turn one form of neuron into another in the brain
7. UGA researchers invent new material for warm-white LEDs
8. NSF Supports GlobalNSF supports global research to advance science and engineering for sustainability
9. RUB researchers find over active enzyme in failing hearts
10. New research throws doubt on earlier killer walrus claims
11. Researchers attack HIVs final defenses before drug-resistant mutations emerge
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Stem cell research helps to identify origins of schizophrenia
(Date:8/31/2014)... study of satellite data from the last 19 years reveals ... around the coast of Antarctica to rise by 2cm more ... University of Southampton detected the rapid rise in sea-level by ... a million square kilometres. , The melting of ... shelves has contributed an excess of around 350 gigatonnes of ...
(Date:8/31/2014)... Over the past several decades, malaria diagnosis has changed very ... technician smears the blood across a glass slide, stains it ... the Plasmodium parasite, which causes the disease. This approach gives ... blood an important measure of disease severity but ... , A research team from the Singapore-MIT Alliance for Research ...
(Date:8/29/2014)... Researchers at UC Davis have made some surprising ... infection. Studying simian immunodeficiency virus (SIV), the team ... Paneth cells are early responders to viral invasion ... producing a cytokine called interleukin-1 beta (IL-1β). ... IL-1β causes breakdown of the gut epithelium that ...
Breaking Biology News(10 mins):A new way to diagnose malaria 2A new way to diagnose malaria 3The early cost of HIV 2
... masked marauder has emerged unexpectedly from the ocean to rescue ... time. , With the dramatic flair of comic-book superhero Batman, ... choked to death by seaweed ?although the fish was never ... the ARC Centre of Excellence for Coral Reef Studies (CoECRS) ...
... have been little more than electronic versions of the ... of PLoS ONE, which publishes primary research from all ... peer review to maximize the impact of every report ... Library of Science (PLoS), the open access publisher whose ...
... substances that regulate neuronal signaling in the brain and ... engineering a mouse with a mutation affecting a neuronal ... zinc in modulating signaling among the neurons. Significantly, they ... to noise as children with the genetic disorder called ...
Cached Biology News:Batfish to the rescue! 2PLoS ONE is launched by the Public Library of Science 2PLoS ONE is launched by the Public Library of Science 3Zinc plays important role in brain circuitry 2
(Date:8/29/2014)... 29, 2014 According to a new market ... global orthobiologics market was valued at USD 3,754.6 million in ... 5,519.9million in 2019at a CAGR of 5.9% from 2013 to ... and above is afflicted by bone and joint disorders, and ... 2020. This has and will continue to increase the demand ...
(Date:8/29/2014)... August 29, 2014 Due to a misstatement ... week, the Adult Stem Cell Technology Center, LLC ( ASCTC ... stem cell therapy research that might benefit ALS patients. ... for new stem cell technologies and therapeutic applications, FRC listed ... Bucket Challenge donors who wish not to support research ...
(Date:8/28/2014)... Ca. (PRWEB) August 28, 2014 Best ... rating for an alcohol-based hand sanitizer, asks food processors ... by comparing the hand sanitizer they’re currently using to ... . Hand hygiene is critical to fighting cross-contamination and ... Best Sanitizers believes there are key criteria that ...
(Date:8/28/2014)... Willow Grove, PA (PRWEB) August 28, 2014 ... talent, and create a culture that will allow individuals ... that are becoming increasingly important for employers looking to ... life science industries are embracing this trend, as the ... the fabric of a company, which will have real ...
Breaking Biology Technology:Global Orthobiologics Market to Reach $5,519.9 Million by 2019: Transparency Market Research 2Global Orthobiologics Market to Reach $5,519.9 Million by 2019: Transparency Market Research 3The Adult Stem Cell Technology Center, LLC Declines ALS Ice Bucket Challenge Donors Wishing to Support Ethical Research for New Stem Cell Therapies 2The Adult Stem Cell Technology Center, LLC Declines ALS Ice Bucket Challenge Donors Wishing to Support Ethical Research for New Stem Cell Therapies 3Food Processors and Food Handlers are Encouraged to Prepare for Fall Harvest by Evaluating Their Current Hand Sanitizer Using Nine Key Criteria 2Food Processors and Food Handlers are Encouraged to Prepare for Fall Harvest by Evaluating Their Current Hand Sanitizer Using Nine Key Criteria 3Klein Hersh International Leads Philadelphia Area Life Science Industry in Company Culture 2Klein Hersh International Leads Philadelphia Area Life Science Industry in Company Culture 3
... Corporation , has built the supply chain industries ... radio frequency identification (RFID) laboratory designed to ... RFID Lab is enabling RedPrairie customers and prospects ... they prepare for RFID compliance. In addition, using ...
... Strategy supports plans for growth and strategic investments ... software and services company, today announced it has signed ... with Merchants and Manufacturers BanCorp (MMBC) , a ... of credit, from which no monies have been drawn, ...
... a Washington, DC, think tank slammed Wisconsins efforts at ... Madison could raise that score, according to the states ... Department of Administration (DOA) after the Department ... said the Center for Economic Development (CFED) ...
Cached Biology Technology:RedPrairie Builds RFID Lab - Enables Real-World Testing 2Wisconsin to Get Serious about E-Government 2Wisconsin to Get Serious about E-Government 3Wisconsin to Get Serious about E-Government 4
... of progressive centrifuge design and manufacturing, Thermo ... and Centra-CL3R (refrigerated) general purpose models provide ... Control Over Sample Preparation , The CL3 ... 99 protocols and has speed and accuracies ...
... Polymerase I Large (Klenow) Fragment, Exonuclease Minus, ... both the 5´→3´ and the 3´→5´ exonuclease ... Polymerase I (1,2). It is used for ... displacement amplification (5). Klenow Fragment, Exonuclease Minus, ...
DNA Polymerase I Large (Klenow) Fragment is a DNA polymerase that lacks the 5'Cut Site3' exodeoxyribonuclease activity of intact DNA Polymerase I but it contains the 3'Cut Site5' exodeoxyribonuclease...
Guanylate Kinase Purified Anti-Mouse, Anti-Rat clone 28, Isotype Mouse IgG 1 , 50 µg Consult technical datasheet for details....
Biology Products: