Navigation Links
Stem-cell research: A new genetic switching element
Date:5/22/2014

is also modified in embryonic stem cells of mice. Moreover, Tet is at work here too. "During the development of specialized tissues from stem cells, enzymes belonging to the Tet family also oxidize the thymidine base, as we have now shown with the aid of highly sensitive analytical methods based on mass spectrometry. The product of the reaction, hydroxymethyluracil, was previously and as it now turns out, erroneously thought to be synthesized by a different pathway," Carell explains.

The precise function of hydroxymethyluracil remains unclear. However, using an innovative method for the identification of factors capable of binding to and "reading" the chemical tags that characterize unconventional DNA bases, Carell and colleagues have shown that stem cells contain specific proteins that recognize hydroxymethyluracil, and could therefore contribute to the regulation of gene activity in these cells. "We hope that these new insights will make it possible to modulate the differentiation of stem cells causing them to generate cells of a particular type," says Carell. "It would be wonderful if we were one day able to generate whole organs starting from differentiated cells produced, on demand, by stem cell populations."


'/>"/>

Contact: Luise Dirscherl
presse@lmu.de
49-892-180-3243
Ludwig-Maximilians-Universitt Mnchen
Source:Eurekalert

Page: 1 2

Related biology news :

1. Stem-cell approach shows promise for Duchenne muscular dystrophy
2. Initial research: Mangos effects on ulcerative colitis & bone parameters in animal models
3. Research: Fructose not responsible for increase in non-alcoholic fatty liver disease
4. New research: Effects of eating half an avocado with lunch on satiety & desire to eat between meals
5. Pioneers in Alzheimers research: Research couple honored for its lifetime achievement
6. New research: Wolf Lake ancient forest is endangered ecosystem
7. DoD-funded research: Can climate change heat up conflict?
8. New Research: Modified Citrus Pectin - A Potent Anti-Cancer Therapy
9. PTSD research: Distinct gene activity patterns from childhood abuse
10. Dartmouth research: The clocks are ticking and the climate is changing
11. Influenza research: Can dynamic mapping reveal clues about seasonality?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... of moorland burning is published today in the first ... of relieving tensions on both sides of the grouse ... Moorland Burning on the Ecohydrology of River basins) project ... practised predominantly to support red grouse populations for gun ... chemistry and physical properties, river water chemistry and river ...
(Date:9/30/2014)... think of nature as something that we enjoy when we ... Or do we think of ourselves as a part of ... what about a house? , The answers to these ... our actions, our speech and in cultural artifacts. , A ... Washington, the American Indian Center of Chicago and the Menominee ...
(Date:9/30/2014)... and strawberries all have in common? Unlike most ... and are diploid, these organisms are all polyploid, meaning ... and salmon have 3 and 4 sets of chromosomes, ... seem surprising, in fact most plant species are polyploid. ... century ago, but only recently, with the development of ...
Breaking Biology News(10 mins):Grouse moor burning causes widespread environmental changes 2The cultural side of science communication 2Gene doubling shapes the world: Instant speciation, biodiversity, and the root of our existence 2Gene doubling shapes the world: Instant speciation, biodiversity, and the root of our existence 3Gene doubling shapes the world: Instant speciation, biodiversity, and the root of our existence 4
... all likely to blame for poisoning the waters being drained from ... is leaving behind -- also owes its contamination to a source ... environments that made their way en masse into the water as ... Florida professor who has spent years studying the harmful contaminants that ...
... conditions and diseases is both feasible and safe, report ... the approach in patients with advanced rheumatoid arthritis. The ... Proceedings of the National Academy of Sciences (PNAS), indicate ... block the destructive inflammation process that takes place within ...
... the number of voices they hear to the number ... have found. The finding indicates that numerical perception is ... of a particular sense, said the researchers. The experimental ... human infants, before they have a verbal capacity, understand ...
Cached Biology News:Toxic flood lifts lid on common urban pollution problem 2Toxic flood lifts lid on common urban pollution problem 3Results of world's first gene therapy trial for arthritis show approach safe, feasible 2Results of world's first gene therapy trial for arthritis show approach safe, feasible 3Results of world's first gene therapy trial for arthritis show approach safe, feasible 4Monkeys understand numbers across senses 2
(Date:9/30/2014)... Follow us on LinkedIn –Cholesterol ... cholesterol carrier or lipoprotein in the blood. Such tests ... in the body, especially along the walls of blood ... other cardiovascular disorders. Cardiovascular Diseases (CVD) is the leading ... on a regular basis, to assess an individual’s risk ...
(Date:9/30/2014)... 2014 CORD:USE Cord Blood Bank – ... has entered into an Equity and Exclusive Services Agreement ... series of patented technologies for the isolation of human ... Tianhe is performing Phase I/II clinical trials in ... using Tianhe,s Stem Cell Educator Therapy showing that ...
(Date:9/30/2014)... 30, 2014 Genedata, a ... drug discovery and related life science research, ... chosen Genedata Selector as its host-pathogen data ... FUNGITECT is a European consortium dedicated to ... via individualized anti-fungal drug therapies. Genedata Selector ...
(Date:9/30/2014)... 30, 2014  KemPharm, Inc., a clinical-stage specialty ... of proprietary new molecular entity (NME) prodrugs, announced ... Office (USPTO) issued U.S. Patent No. 8,816,083 to ... Benzoic Acid Derivatives and Heteroaryl Carboxylic Acid Conjugates ... Thereof." The patent, which extends through ...
Breaking Biology Technology:Surging Diabetic, Obese and Hypertensive Population Drives the Global Cholesterol Testing Market, According to New Report by Global Industry Analysts, Inc. 2Surging Diabetic, Obese and Hypertensive Population Drives the Global Cholesterol Testing Market, According to New Report by Global Industry Analysts, Inc. 3Surging Diabetic, Obese and Hypertensive Population Drives the Global Cholesterol Testing Market, According to New Report by Global Industry Analysts, Inc. 4CORD:USE is Pleased to Announce it has Partnered with Tianhe Stem Cell Biotechnologies, Developer of Cord Blood Stem Cell Therapy Showing Promising Results in Clinical Trials for the Treatment of Diabetes and Autoimmune Diseases 2CORD:USE is Pleased to Announce it has Partnered with Tianhe Stem Cell Biotechnologies, Developer of Cord Blood Stem Cell Therapy Showing Promising Results in Clinical Trials for the Treatment of Diabetes and Autoimmune Diseases 3CORD:USE is Pleased to Announce it has Partnered with Tianhe Stem Cell Biotechnologies, Developer of Cord Blood Stem Cell Therapy Showing Promising Results in Clinical Trials for the Treatment of Diabetes and Autoimmune Diseases 4FUNGITECT Consortium Adopts Genedata Selector as Data Analysis Platform for Anti-fungal R 2FUNGITECT Consortium Adopts Genedata Selector as Data Analysis Platform for Anti-fungal R 3KemPharm, Inc. Receives Patent from the USPTO for Novel Prodrug of Hydromorphone, KP511 2
... ... the slate of SDS Clinical Trials. Nissan Pilest, Medical Director of Total Dermatology in Irvine, ... ... Well known Orange County Dermatologist and Laser Physician, Nissan Pilest , has been selected ...
... PRINCETON, N.J., July 28 Laureate Pharma, ... today announced the appointment of Daniel E. Leone as ... responsible for Laureate,s worldwide business development activities, including sales ... contract development, manufacturing, and bioprocessing business. , ...
... , DOYLESTOWN, Pa., July 28 ... company to offer a broad range of accredited CME courses in ... clinical trials. , , The comprehensive education and ... Institute (BRITI)(TM). RadMD is partnering with International Center for Postgraduate Medical ...
Cached Biology Technology:Seasoned Dermatologist Nissan Pilest of Irvine, CA, Joins SDS Clinical Trials as Clinical Investigator for Dermatology Division 2Laureate Pharma Appoints Daniel E. Leone as Vice President of Business Development 2RadMD First to Offer CME-Certified Education and Training For Medical Imaging in Clinical Trials 2
Mouse monoclonal antibody raised against a partial recombinant TPR. NCBI Entrez Gene ID = TPR...
... sample is a complex protein sample, ... when used with ReadyPrep 2-D starter ... sample can be used as a ... and protocol before using more difficult ...
... materials for 1,464 array sample elements. , ,Includes: ... , Blocker BSA in PBS (10X): 50 ml ... g , BupH Phosphate Buffered Saline: ... 2 x 10 ml ampules , SuperSignal West Pico ...
... Mouse polyclonal antibody raised ... Immunogen: ... 112 a.a) partial recombinant protein ... Accession Number: NM_130777 ...
Biology Products: