Navigation Links
Stem cell protein offers a new cancer target
Date:6/1/2009

A protein abundant in embryonic stem cells is now shown to be important in cancer, and offers a possible new target for drug development, report researchers from the Stem Cell Program at Children's Hospital Boston.

Last year, George Daley, MD, PhD, and graduate student Srinivas Viswanathan, in collaboration with Richard Gregory, PhD, also of the Stem Cell Program at Children's, showed that the protein LIN28 regulates an important group of tumor-suppressing microRNAs known as let-7. Increasing LIN28 production in a cell prevented let-7 from maturing, making the cell more immature and stem-like. Since these qualities also make a cell more cancerous, and because low levels of mature let-7 have been associated with breast and lung cancer, the discovery suggested that LIN28 might be oncogenic.

Now, publishing Advance Online in Nature Genetics on May 31, Daley, Viswanathan and colleagues show directly that LIN28 can transform cells to a cancerous state, and that it is abundant in a variety of advanced human cancers, particularly liver cancer, ovarian cancer, chronic myeloid leukemia, germ cell tumors and Wilm's tumor (a childhood kidney cancer). They believe that overall, LIN28 and a related protein, LIN28B, may be involved in some 15 percent of human cancers. By blocking or suppressing LIN28, it might be possible to revive the let-7 family's natural tumor-suppressing action.

"Linking this protein to advanced cancer is a very exciting new result," says Daley, Director of Stem Cell Transplantation at Children's, and also affiliated with Children's Division of Hematology/Oncology, the Dana-Farber Cancer Institute and the Harvard Stem Cell Institute. "It gives us a new target to attack, especially in the most resistant and hard-to-treat cases."

LIN28, which is abundant in embryonic stem cells and prevents them from differentiating into specific cell types, was originally discovered to influence embryonic development in worms so
'/>"/>

Contact: Elizabeth Andrews
elizabeth.andrews@childrens.harvard.edu
617-919-3110
Children's Hospital Boston
Source:Eurekalert

Page: 1 2

Related biology news :

1. Protein chatter linked to cancer activation
2. Scientists link fragile X tremor/ataxia syndrome to binding protein in RNA
3. Researchers identify proteins involved in new neurodegenerative syndrome
4. Low levels of key protein may indicate pancreatic cancer risk
5. Structure of 450 million year old protein reveals evolutions steps
6. Scientists retrace evolution with first atomic structure of an ancient protein
7. Specific brain protein required for nerve cell connections to form and function
8. NIH awards researcher $1.5 million new innovator grant for fruit-fly studies of prion proteins
9. Interacting protein theory awaits test from new neutron analysis tools
10. Depression, aging, and proteins made by a virus may all play role in heart disease
11. Census of protein architectures offers new view of history of life
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/11/2015)... RYE, N.Y. , May 11, 2015 ... company, announced the start of a new Phase III ... effect of its novel formulation, CM-AT, on all children ... results of its FDA Phase III double blinded clinical ... who had low levels of the digestive enzyme chymotrypsin. ...
(Date:5/5/2015)... OXFORD, Conn. , May 5, 2015, NXT-ID, ... biometric authentication company focused on the growing mobile commerce market, ... the Company,s Chief Technology Officer, is presenting  at CARTES SECURE ... May 5-7, 2015. The three-day conference ... session David is speaking in is themed Global Fraud: ...
(Date:4/20/2015)... Huntington Memorial Hospital is the first facility ... miniaturized, wireless monitoring sensor to manage heart failure (HF). ... FDA-approved heart failure monitoring device that has been proven ... to manage heart failure. The CardioMEMS HF ... pulmonary artery (PA) during a non-surgical procedure to directly ...
Breaking Biology News(10 mins):Curemark, LLC, Launches New Phase III Trial in Expanded Population of Children with Autism 2NXT-ID, Inc.'s CTO, David Tunnell, Presents at CARTES SECURE CONNEXIONS AMERICA 2015 Today in Washington DC. 2NXT-ID, Inc.'s CTO, David Tunnell, Presents at CARTES SECURE CONNEXIONS AMERICA 2015 Today in Washington DC. 3Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 2Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 3
... Most people who carry a genetic mutation for a ... phenomenon that has puzzled scientists since the first genetic ... The Feinstein Institute for Medical Research have figured out ... the disorder they have an additional lesion that ...
... PA, 5 August 2009 - It is important to ... to be resilient under conditions of extreme stress, such ... Dr. Charles A. Morgan III and his colleagues ... PTSD have worked closely with collaborators at the Special ...
... flies and other insects that encounter nanomaterial "hot spots," or ... and transport nanoparticles on their bodies, transferring the particles to ... carbon nanoparticles barely 1/5,000th the width of a human ... Environmental Science & Technology , a semi-monthly journal. ...
Cached Biology News:Abnormal brain circuits may prevent movement disorder 2Hormone levels contribute to stress resilience 2
(Date:5/28/2015)... 2015 Whitehouse Laboratories is excited to ... term partnership with PTI Inspection Systems. Whitehouse Labs and ... with custom-tailored method development and validation programs using ... The agreement includes a more formal program that facilitates ... lines. This enables a more effective team approach, especially ...
(Date:5/28/2015)... In two different WPC forums , ... will present the company’s unique approach to developing technologies ... he will describe Asymmetrex ’s innovation in integrating ... to produce the first-ever technology for quantitative monitoring of ... in culture. When leading an interactive breakout discussion ...
(Date:5/27/2015)... , May 26, 2015 ... announced the addition of Jain PharmaBiotech,s new ... and Companies" to their offering. ... molecular diagnostics technologies that will play an ... health, pharmaceutical industry, forensics and biological warfare ...
(Date:5/27/2015)... , May 27, 2015 /CNW/ - CQDM, Brain Canada ... to $8.5M to six (6) multi-disciplinary and multi-provincial research ... within their Focus on Brain strategic initiative. To this ... involved as in-kind contributions. This exciting announcement was made ... for Neuroscience in the presence of Inez Jabalpurwala, President ...
Breaking Biology Technology:Whitehouse Labs Renews & Enhances Partnership with PTI Inspection Systems 2Whitehouse Labs Renews & Enhances Partnership with PTI Inspection Systems 3Asymmetrex Will Discuss the Importance of Adult Tissue Stem Cell Time with 3D Tissue Engineers at the 14th Annual World Preclinical Congress in Boston in June 2Asymmetrex Will Discuss the Importance of Adult Tissue Stem Cell Time with 3D Tissue Engineers at the 14th Annual World Preclinical Congress in Boston in June 3Global Molecular Diagnostics Market 2015-2024 - Analysis of Key Technologies, Markets and Companies 2Global Molecular Diagnostics Market 2015-2024 - Analysis of Key Technologies, Markets and Companies 3Focus on Brain: $10M for breakthrough technologies to address unmet needs in neurosciences 2Focus on Brain: $10M for breakthrough technologies to address unmet needs in neurosciences 3Focus on Brain: $10M for breakthrough technologies to address unmet needs in neurosciences 4Focus on Brain: $10M for breakthrough technologies to address unmet needs in neurosciences 5Focus on Brain: $10M for breakthrough technologies to address unmet needs in neurosciences 6Focus on Brain: $10M for breakthrough technologies to address unmet needs in neurosciences 7Focus on Brain: $10M for breakthrough technologies to address unmet needs in neurosciences 8Focus on Brain: $10M for breakthrough technologies to address unmet needs in neurosciences 9Focus on Brain: $10M for breakthrough technologies to address unmet needs in neurosciences 10
... Wis. - This summer, venture investors deployed more than ... that may bode well for improving on the state's 2005 ... conclusions from one quarter of investment activity, the number could ... a growing base of capital in 2006. , ,"With the ...
... theft (IDT), yet unless you have been a victim, few ... figure is that over half of the 10 million new ... or other entity (not-for-profit or local, state, or federal government). ... or more federal and state laws to implement measures, policies, ...
... Two news stories in the past week have stirred ... the state competing in the global economy, as CDW ... a low-talent, high-tax backwater, as RedPrairie executive John Jazwiec ... to Jazwiec when he says he has trouble recruiting ...
Cached Biology Technology:Summer venture investments total $18 million for Wisconsin start ups 2Summer venture investments total $18 million for Wisconsin start ups 3Summer venture investments total $18 million for Wisconsin start ups 4Identity theft: The business time bomb 2Identity theft: The business time bomb 3Identity theft: The business time bomb 4Who's right about Wisconsin - CDW or RedPrairie? 2Who's right about Wisconsin - CDW or RedPrairie? 3
... The Multiple Species Tissue Array (MSTA) slides were ... cells and tissues from multiple species. Tissue ... each MSTA slide which can then be treated ... immunohistochemistry, or in situ hybridization. ...
... Clear yellow solution. ... 0.01% thimerosal, and other ... filtered. Diluent formulated to ... peroxidase antibody conjugates at ...
... cells-directed transfection reagent : jetPEI-RGD ... which allows targeted efficient transfection ... cells. Integrins are adhesion molecules ... adhesion processes. Many integrins, including ...
...
Biology Products: