Navigation Links
Stem cell protein offers a new cancer target
Date:6/1/2009

A protein abundant in embryonic stem cells is now shown to be important in cancer, and offers a possible new target for drug development, report researchers from the Stem Cell Program at Children's Hospital Boston.

Last year, George Daley, MD, PhD, and graduate student Srinivas Viswanathan, in collaboration with Richard Gregory, PhD, also of the Stem Cell Program at Children's, showed that the protein LIN28 regulates an important group of tumor-suppressing microRNAs known as let-7. Increasing LIN28 production in a cell prevented let-7 from maturing, making the cell more immature and stem-like. Since these qualities also make a cell more cancerous, and because low levels of mature let-7 have been associated with breast and lung cancer, the discovery suggested that LIN28 might be oncogenic.

Now, publishing Advance Online in Nature Genetics on May 31, Daley, Viswanathan and colleagues show directly that LIN28 can transform cells to a cancerous state, and that it is abundant in a variety of advanced human cancers, particularly liver cancer, ovarian cancer, chronic myeloid leukemia, germ cell tumors and Wilm's tumor (a childhood kidney cancer). They believe that overall, LIN28 and a related protein, LIN28B, may be involved in some 15 percent of human cancers. By blocking or suppressing LIN28, it might be possible to revive the let-7 family's natural tumor-suppressing action.

"Linking this protein to advanced cancer is a very exciting new result," says Daley, Director of Stem Cell Transplantation at Children's, and also affiliated with Children's Division of Hematology/Oncology, the Dana-Farber Cancer Institute and the Harvard Stem Cell Institute. "It gives us a new target to attack, especially in the most resistant and hard-to-treat cases."

LIN28, which is abundant in embryonic stem cells and prevents them from differentiating into specific cell types, was originally discovered to influence embryonic development in worms so
'/>"/>

Contact: Elizabeth Andrews
elizabeth.andrews@childrens.harvard.edu
617-919-3110
Children's Hospital Boston
Source:Eurekalert

Page: 1 2

Related biology news :

1. Protein chatter linked to cancer activation
2. Scientists link fragile X tremor/ataxia syndrome to binding protein in RNA
3. Researchers identify proteins involved in new neurodegenerative syndrome
4. Low levels of key protein may indicate pancreatic cancer risk
5. Structure of 450 million year old protein reveals evolutions steps
6. Scientists retrace evolution with first atomic structure of an ancient protein
7. Specific brain protein required for nerve cell connections to form and function
8. NIH awards researcher $1.5 million new innovator grant for fruit-fly studies of prion proteins
9. Interacting protein theory awaits test from new neutron analysis tools
10. Depression, aging, and proteins made by a virus may all play role in heart disease
11. Census of protein architectures offers new view of history of life
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/13/2014)... women suggests that experiencing one or more stressful events ... slow the body,s metabolism, potentially contributing to weight gain. ... stressors before giving them a meal consisting of 930 ... measured their metabolic rate how long it took ... took measures of blood sugar, triglycerides, insulin and the ...
(Date:7/13/2014)... available in French . ... international research project, led by the Research Institute of ... that a new oral medication is showing significant progress ... (LCA). Until now, this inherited retinal disease that causes ... has remained untreatable. The study is published today in ...
(Date:7/13/2014)... prospect of more effective treatments for cachexia, a profound ... of all cancer patients, raising their risk of death, ... strategies have been tried to reverse the condition, which ... life-saving treatments, but none have had great success. , ... of Nature , led by Bruce Spiegelman, PhD, ...
Breaking Biology News(10 mins):Weighty issue: Stress and high-fat meals combine to slow metabolism in women 2Weighty issue: Stress and high-fat meals combine to slow metabolism in women 3Weighty issue: Stress and high-fat meals combine to slow metabolism in women 4MUHC researcher unveils novel treatment for a form of childhood blindness 2Antibody halts cancer-related wasting condition 2Antibody halts cancer-related wasting condition 3
... derivative, and was approved for the treatment of neuropathic ... 2002. However, little evidence is available on the effects ... attack period. A recent study by Yanbo Zhang and ... showed that excitatory amino acids and protein kinase C ...
... Ectobius is a major textbook example of an invasive ... region from northernmost Europe to southernmost Africa. Ectobius ... amber that is about 44 million years old, and its lineage ... a shocking new discovery has uprooted that view. In fact, it ...
... stink bugs as pests, especially as the brown marmorated stink ... beneficial, such as Podisus nigrispinus (Dallas), a predatory ... for various insect pests of cotton, soybean, tomato, corn, kale, ... Annals of the Entomological Society of America called ...
Cached Biology News:After a 49-million-year hiatus, a cockroach reappears in North America 2New study may aid rearing of stink bugs for biological control 2
(Date:7/11/2014)... BEACH, Fla. , July 11, 2014 /PRNewswire-iReach/ -- ... of high-quality peptides that are used solely in scientific ... honor two successful years in business, Maxim Peptide, which ... has just launched a new and updated website that ... research blog section has been updated with fascinating articles ...
(Date:7/11/2014)... Research and Markets  has announced the ... Global Industry Analysis, Size, Share, Growth, Trends and Forecast ... http://photos.prnewswire.com/prnh/20130307/600769 Transfection is ... or RNA) into cells. This technology helps the cells ... protein metabolism by affecting the nuclear genes. The transfection ...
(Date:7/11/2014)... , July 11, 2014 EPFL ... announce the appointment of John P. Donoghue . ...   in  Geneva . The new ... Biotech in Geneva , has named ... neuroscientists. John P. Donoghue , founder of Brown ...
(Date:7/11/2014)... July 11, 2014  Researchers have pioneered a ... The new technology, called Virtual Finger, allows scientists ... like neurons and synapses using the flat surface ... makes 3D imaging studies orders of magnitude more ... unprecedented level across many areas of experimental biology. ...
Breaking Biology Technology:Maxim Peptide Celebrates Second Anniversary Online with an Updated Website and Special Deals Section 2International Transfection Technology Market - Industry Analysis, Size, Share, Growth, Trends and Forecast to 2019 2John P. Donoghue is Taking the Lead at the Wyss Center and is Appointed Professor at EPFL and University of Geneva 2John P. Donoghue is Taking the Lead at the Wyss Center and is Appointed Professor at EPFL and University of Geneva 3Virtual Finger Enables Scientists To Navigate And Analyze 3D Images Of Complex Biological Structures 2Virtual Finger Enables Scientists To Navigate And Analyze 3D Images Of Complex Biological Structures 3
... YORK, Oct. 6, 2011 A new invention could ... is a portable, rapid pathogen screener that could ... in processing plants, before it is delivered to the ... as a single bacteria, and is approximately 50 times ...
... 6, 2011 ProteinSimple today announced the launch ... control monitoring of protein-based therapeutics. The iCE3 platform ... conference, October 9-13, 2011, at Amelia Island, FL. ... product purity closely. Imaged capillary electrophoresis (iCE) systems ...
... Luminex Corporation (NASDAQ: LMNX ) announced today that ... – Be The Match to raise awareness of the need ... match for the growing number of patients awaiting life-saving bone ... National Marrow Donor Registry in an effort to assist patients ...
Cached Biology Technology:Breakthrough in Preventing Food-borne Illnesses Wins $20,000 Grand Prize in Global Design Contest 2Breakthrough in Preventing Food-borne Illnesses Wins $20,000 Grand Prize in Global Design Contest 3Breakthrough in Preventing Food-borne Illnesses Wins $20,000 Grand Prize in Global Design Contest 4ProteinSimple Launches New System for Protein Biologics 2Luminex Corporation Joins Forces With the National Marrow Donor Program - Be The Match® 2Luminex Corporation Joins Forces With the National Marrow Donor Program - Be The Match® 3Luminex Corporation Joins Forces With the National Marrow Donor Program - Be The Match® 4
Mouse monoclonal [3G131] to Desmoglein 1 ( Abpromise for all tested applications). entrezGeneID: 1828 SwissProtID: Q02413...
Mouse monoclonal [2D7/1] to E.coli LPS ( Abpromise for all tested applications). Antigen: Tissue / cell preparation: Escherichia coli J5 cells....
COMING SOON: Anti-Mouse C5/C5b, Clone BB5.1. Monoclonal Antibody...
KAI 1 (G-2)...
Biology Products: