Navigation Links
Stem cell proliferation and differentiation observed within hydrogel
Date:4/11/2013

Stem cells can be coaxed to grow into new bone or new cartilage better and faster when given the right molecular cues and room inside a water-loving gel, researchers at Case Western Reserve University show.

By creating a three-dimensional checkerboardone with alternating highly connected and less connected spaces within the hydrogelthe team found adjusting the size of the micropattern could affect stem cell behaviors, such as proliferation and differentiation.

Inducing how and where stem cells growand into the right kind of cell in three dimensionshas proven a challenge to creating useful stem cell therapies. This technique holds promise for studying how physical, chemical and other influences affect cell behavior in three-dimensions, and, ultimately, as a method to grow tissues for regenerative medicine applications.

"We think that control over local biomaterial properties may allow us to guide the formation of complex tissues," said Eben Alsberg, an associate professor of Biomedical Engineering at Case Western Reserve. "With this system, we can regulate cell proliferation and cell-specific differentiation into, for example, bone-like or cartilage-like cells."

Oju Jeon, PhD, a postdoctoral researcher in Biomedical Engineering, pursued this work with Alsberg. Their work is described April 11, 2013 in the online edition of Advanced Functional Materials.

Hydrogels are hydrophilic three-dimensional networks of water-soluble polymers bonded, or crosslinked, to one another. Crosslinks increase rigidity and alter the porous structure inside the gel.

Alsberg and Jeon used a hydrogel of oxidized methacrylated alginate and an 8-arm poly(ethylene glycol) amine. A chemical reaction between the alginate and the poly(ethylene glycol) creates crosslinks that provide structure within the gel.

They tweaked the mix so that a second set of crosslinks forms when exposed to light. They used checkerboard masks
'/>"/>

Contact: Kevin Mayhood
kevin.mayhood@case.edu
216-368-4442
Case Western Reserve University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Successful stem cell differentiation requires DNA compaction, study finds
2. The first ant methylomes uncover the relationship between DNA methylation and caste differentiation
3. Warmest spring on record causes earliest flowering ever observed in eastern U.S.
4. Boston Healthcare Associates Roundtable Explores Challenges and Opportunities Surrounding the Value of Big Data within the Life Sciences
5. New study suggests that Arabica coffee could be extinct in the wild within 70 years
6. New type of bacterial protection found within cells
7. One law to rule them all -- sizes within a species appear to follow a universal distribution
8. Morphing DNA hydrogel flows like liquid but remembers its original shape
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/29/2015)... Research and Markets( http://www.researchandmarkets.com/research/zj7h4f/latin_america ... America Biomedical Sensors Market - Growth, Trends & Forecasts ... Latin America Biomedical Sensors market is estimated at $0.65 ... the period 2014-2020 The near future will ... formulation of each individual. These sensors can be set ...
(Date:6/25/2015)... N.J. , June 25, 2015  TAKE Solutions ... a patent by the United States Patent and Trademark ... Standardization". This process leverages TAKE Solutions, Clinical Accelerators to ... over 50% (when compared to standardization without the accelerators), ... At the heart of ...
(Date:6/24/2015)... , June 22, 2015 ... the addition of the "Huawei Ascend Mate ... report to their offering. Huawei,s technological ... the opposite direction than Apple,s and Samsung,s one. ... sensor developed by Fingerprint Cards, a main actor ...
Breaking Biology News(10 mins):Latin America Biomedical Sensors Market Report 2015-2020 2TAKE Solutions Awarded Patent By USPTO 2Huawei Ascend Mate 7 Fingerprint Sensor - Reverse Costing Analysis 2
... nature when scientists succeeded in creating a new type ... occurring enzyme has evolved. This achievement opens the door ... in medicine and industry. Enzymes are, without ... works of nature. These molecular machines which without ...
... FOR IMMEDIATE RELEASE Toward a new generation ... Accounts of Chemical Research Researchers in Colombia, ... next generation of synthetic vaccines that could lead to ... other infectious diseases. These conditions kill more than 17 ...
... the red flour beetle living happily in the flour sack ... University, and many others throughout the world, this pest of ... studying genetics. The superior status of this beetle, Tribolium ... work of two Kansas State University faculty, Susan Brown, professor ...
Cached Biology News:Birth of an enzyme 2Birth of an enzyme 3American Chemical Society's Weekly PressPac -- March 19, 2008 2American Chemical Society's Weekly PressPac -- March 19, 2008 3American Chemical Society's Weekly PressPac -- March 19, 2008 4American Chemical Society's Weekly PressPac -- March 19, 2008 5American Chemical Society's Weekly PressPac -- March 19, 2008 6American Chemical Society's Weekly PressPac -- March 19, 2008 7American Chemical Society's Weekly PressPac -- March 19, 2008 8American Chemical Society's Weekly PressPac -- March 19, 2008 9
(Date:7/29/2015)... ... July 29, 2015 , ... Brady (NYSE:BRC), ... GHS Label Guide . To align chemical container labeling with OSHA’s updated Hazard ... of label components, an example of an accurate label, and pictogram uses and ...
(Date:7/29/2015)... SAN DIEGO , July 29, 2015  Pfenex ... quarter 2015 financial results will be released on Thursday, ... 8:30 am Eastern Time, Pfenex management will host a ... a business update.  A press release outlining the financial ... to the call. Please call 1-866-376-8058 (US) ...
(Date:7/29/2015)... VANCOUVER , July 29, 2015 /PRNewswire/ - RepliCel ... clinical stage regenerative medicine company, is pleased to announce ... dermal injector (RCI-02) have been locked.  Prototypes for ... to prepare for an application for CE mark ... Europe in 2016. (Photo: ...
(Date:7/29/2015)... San Bruno, CA. (PRWEB) , ... July 29, ... ... partnership agreement with PRC Clinical, a Silicon Valley-based CRO specializing in ... FDA advisory services, and patient recruitment services. The core expertise of PRC Clinical ...
Breaking Biology Technology:Brady Announces a New GHS Label Guide 2Pfenex To Report Second Quarter 2015 Results and Provide Business Update on Thursday, August 13, 2015 2RepliCel Life Sciences Unveils Innovative Dermal Injector Prototype 2RepliCel Life Sciences Unveils Innovative Dermal Injector Prototype 3RepliCel Life Sciences Unveils Innovative Dermal Injector Prototype 4RepliCel Life Sciences Unveils Innovative Dermal Injector Prototype 5CSSi LifeSciences And PRC Clinical Join Forces To Offer Extended Clinical Trial Services 2CSSi LifeSciences And PRC Clinical Join Forces To Offer Extended Clinical Trial Services 3
... developing solutions based on the products of newborn fibroblasts, today launched ... culturing kit for stem cell growth. The kit was launched and ... place in Madison, Wisconsin. , ... San Diego, CA ...
... northern China indicates that genetically modified cotton, altered to express ... crops, but also reduces pests among other nearby crops that ... promising new ideas for controlling pests and maximizing crop yields ... by the journal Science on Friday, 19 September. ...
... a significant milestone for the growing open source clincial trials ... towards the needs of regulated industry sponsored clinical trials. ... ... 2008 -- Akaza Research announces the availability of OpenClinica 2.5, ...
Cached Biology Technology:Histogen Launches BioNuesis, the Only All-Human Stem Cell Culturing Kit 2Histogen Launches BioNuesis, the Only All-Human Stem Cell Culturing Kit 3GM crops protect neighbors from pests 2Akaza Research Releases New Version of OpenClinica Electronic Data Capture (EDC) Software; Targets Industry Clinical Trials 2Akaza Research Releases New Version of OpenClinica Electronic Data Capture (EDC) Software; Targets Industry Clinical Trials 3
Water Distilled (Gibco™) is membrane filtered and endotoxin screened....
The S. cerevisiae Hansen strains are the parental yeast strains from which the deletions were derived....
Immunogen: Human Respiratory Syncytial Virus (RSV) and Bovine Respiratory Syncytial Virus (BRSV) Fusion protein Storage: -20 C, Avoid Freeze/Thaw Cycles...
The Hybrid Hunter Yeast Two-Hybrid System uses the activation of reporter genes to indicate positive protein-protein interactions. Two reporters are used an auxotrophic marker and lacZ....
Biology Products: