Navigation Links
Stem cell proliferation and differentiation observed within hydrogel
Date:4/11/2013

Stem cells can be coaxed to grow into new bone or new cartilage better and faster when given the right molecular cues and room inside a water-loving gel, researchers at Case Western Reserve University show.

By creating a three-dimensional checkerboardone with alternating highly connected and less connected spaces within the hydrogelthe team found adjusting the size of the micropattern could affect stem cell behaviors, such as proliferation and differentiation.

Inducing how and where stem cells growand into the right kind of cell in three dimensionshas proven a challenge to creating useful stem cell therapies. This technique holds promise for studying how physical, chemical and other influences affect cell behavior in three-dimensions, and, ultimately, as a method to grow tissues for regenerative medicine applications.

"We think that control over local biomaterial properties may allow us to guide the formation of complex tissues," said Eben Alsberg, an associate professor of Biomedical Engineering at Case Western Reserve. "With this system, we can regulate cell proliferation and cell-specific differentiation into, for example, bone-like or cartilage-like cells."

Oju Jeon, PhD, a postdoctoral researcher in Biomedical Engineering, pursued this work with Alsberg. Their work is described April 11, 2013 in the online edition of Advanced Functional Materials.

Hydrogels are hydrophilic three-dimensional networks of water-soluble polymers bonded, or crosslinked, to one another. Crosslinks increase rigidity and alter the porous structure inside the gel.

Alsberg and Jeon used a hydrogel of oxidized methacrylated alginate and an 8-arm poly(ethylene glycol) amine. A chemical reaction between the alginate and the poly(ethylene glycol) creates crosslinks that provide structure within the gel.

They tweaked the mix so that a second set of crosslinks forms when exposed to light. They used checkerboard masks
'/>"/>

Contact: Kevin Mayhood
kevin.mayhood@case.edu
216-368-4442
Case Western Reserve University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Successful stem cell differentiation requires DNA compaction, study finds
2. The first ant methylomes uncover the relationship between DNA methylation and caste differentiation
3. Warmest spring on record causes earliest flowering ever observed in eastern U.S.
4. Boston Healthcare Associates Roundtable Explores Challenges and Opportunities Surrounding the Value of Big Data within the Life Sciences
5. New study suggests that Arabica coffee could be extinct in the wild within 70 years
6. New type of bacterial protection found within cells
7. One law to rule them all -- sizes within a species appear to follow a universal distribution
8. Morphing DNA hydrogel flows like liquid but remembers its original shape
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/10/2014)... 9, 2014  Valencell, a leader in performance biometric ... staggering demand from its licensees for highly accurate, clinically ... not solely coming from fitness and health sectors, but ... "A wearable is only as useful as the biometric ... ultimate driver in long-term mass consumer adoption of wearable ...
(Date:12/10/2014)... , Dec. 9, 2014 CIE San ... catalyst that provides the connective tissue that enhances care ... them to easily share client-level information; earned a second ... expand to organizations serving seniors aging in community and; ... partner on December 11 th 4-6p. ...
(Date:12/10/2014)... 9, 2014     ...   Jifflenow, a ... solutions for business-to-business (B2B) events, today announced a ... mobile near-field communication (NFC), Bluetooth low energy (BLE), ... http://photos.prnewswire.com/prnh/20140612/691055) , Jifflenow will integrate its ...
Breaking Biology News(10 mins):Wearable Technology Products Demand Highly Accurate Biometric Technology 2Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 2Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 3Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 4Jifflenow And ITN International Bring Cutting-Edge Badge Scanning Technology To B2B Events 2Jifflenow And ITN International Bring Cutting-Edge Badge Scanning Technology To B2B Events 3
... Cold seeps are deep-sea environments, usually a few square ... diffusion from the sea floor. Mud volcanoes which are ... discovered in the 1990s. These harsh conditions give rise ... environments for life to exist on the planet. ...
... is commonly thought that animals can be arranged along ... humans inevitably at the top, followed by our close ... and other slimy creatures. Over the past decade, this ... and great social complexity in other animals. For example, ...
... the growth of brain cells during development appears to ... according to researchers at UC Irvine. The findings could ... cognitive decline associated with normal aging and diseases such ... early online edition of the Proceedings of the National ...
Cached Biology News:Life in the extreme 2Fishy cooperation 2Proteins necessary for brain development found to be critical for long-term memory 2
(Date:12/19/2014)...  Roche (SIX: RO, ROG; OTCQX: RHHBY) announced ... a privately held company based in ... a big data platform for centralized management and ... proprietary on-market Genomic Management Solution, Bina-GMS 1 , ... fast and scalable analyses to maximize the value ...
(Date:12/19/2014)... 18, 2014 BioPlus Specialty ... specialty pharmacies, has an expanded team of Regional ... consultants for prescriber offices in their regions, with ... “We have a variety of Regional Pharmaceutical Care ... specializing in hepatitis C help prescribers understand all ...
(Date:12/19/2014)... 18, 2014 Reports from CDC ... States suffer from one or more chronic health conditions ... Medication can address some of these diseases, but may ... many sufferers face. While implanted nerve stimulation devices today ... whole nerve, which can induce side effects. , ...
(Date:12/19/2014)... 18, 2014 With only 2 weeks ... special on Sartorius Biohit products . The product specials ... Picus Electronic Pipette Trade-in Program, and free pipette tips. ... officers around the world. They are ideal for lab ... include:, ,     Full volume range of 0.1 ...
Breaking Biology Technology:Roche acquires Bina Technologies and enters the genomic informatics market 2Roche acquires Bina Technologies and enters the genomic informatics market 3BioPlus Specialty Pharmacy Expands ‘Regional Pharmaceutical Care Liaison’ Team 2BioPlus Specialty Pharmacy Expands ‘Regional Pharmaceutical Care Liaison’ Team 3Draper Wins GSK Funding for Smaller, Smarter Implantable Devices 2Major Pipette Distributor Pipette.com Announces Sartorius Year End Specials 2
... MENLO PARK, Calif., June 3 Kornberg Associates | ... to design the research areas of the new Malaysia ... announcement. , , The Malaysia Genome ... research organization launched by the Malaysian government in April ...
... InterMune, Inc. (Nasdaq: ITMN ) today announced ... InterMune, will present at the Goldman Sachs 30th Annual Global ... 2:35 p.m. ET. , , To access ... interested parties may log on to the investor relations page ...
... the House Nancy Pelosi (D-CA) apparently couldn,t resist injecting divisive ... of President Ronald Reagan today on Capital Hill. And ... misleading people again, this time with her statements on stem ... http://www.newscom.com/cgi-bin/prnh/20080930/FRCLOGO ) , , In discussing Nancy ...
Cached Biology Technology:Kornberg Associates Architects Selected to Design Research Areas of Malaysia Genome Institute 2
... provides both long and short-term enriched housing ... in both quarantine and non-quarantine settings on ... also available utilizing our state-of-the-art social housing ... equipped with on site CDC quarantine facilities. ...
... This exceptionally sensitive nucleic acid gel stain ... low background in gels, making it ideal for ... standard UV transilluminators. SYBR Green I nucleic ... capillary electrophoresis, real-time PCR assays and bandshift ...
Synonym: modified Grace's Insect medium...
Schneider's Drosophila - Insect medium...
Biology Products: