Navigation Links
Stem cell patch may result in improved function following heart attack
Date:11/15/2010

CINCINNATIUniversity of Cincinnati (UC) researchers have found that applying a stem cell-infused patch together with overexpression of a specific cell instruction molecule promoted cell migration to damaged cardiac tissue following heart attack and resulted in improved function in animal models.

The researchers also found that function improved more so than when stem cells were directly injected in heart tissuea therapy that is being studied elsewhere.

These findings are being presented for the first time at the American Heart Association's Scientific Meeting in Chicago on Nov. 15.

Researchers in the department of pathology and laboratory medicine led by Yi-Gang Wang, PhD, found that when a tri-cell patch, made up of cardiomyocytes (to restore heart contractility), endothelial cells (to build new blood vessels) and embryonic fibroblasts (to provide support to the cell structure), was applied to the surface of the damaged area of the heart, better outcomes in overall heart function resulted.

"Following myocardial infarction, better known as heart attack, tissue becomes damaged and scarred, cardiomyocytes die and heart pump function is reduced," Wang says. "There are therapies being tested by other researchers where stem cells are injected directly into damaged heart muscle to see if contractile function can be restored.

"In our current study, we wanted to determine if the amplified instructions from overexpressed miR-29, a microRNA, in animal models would enhance the effectiveness of the cell patch by reducing barriers in the infarcted area, leading to enhanced regeneration of heart tissues and resulting in the restoration of heart function after myocardial infarction."

Researchers first generated cardiac progenitor cellscells that can become various cardiac tissue cell typesfrom induced pluripotent stem cells (iPSC). These stem cells can differentiate into any type of cell in the body and are artificially de
'/>"/>

Contact: Katie Pence
katie.pence@uc.edu
513-558-4561
University of Cincinnati Academic Health Center
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. New pump created for microneedle drug-delivery patch
2. Ocean stirring and plankton patchiness
3. Even small patches of urban woods are valuable for migrating birds
4. Ancient artifacts reveals as northern ice patches melt
5. Penn team uses self-assembly to make molecule-sized particles with patches of charge
6. Isolated forest patches lose species, diversity
7. Networks of small habitat patches can preserve urban biodiversity
8. Sweat it out: UH study examines ability of sweat patches to monitor bone loss
9. PDL BioPharma to Announce Third Quarter 2010 Financial Results on November 10, 2010
10. Aware, Inc. Reports Third Quarter 2010 Financial Results
11. Mathematical model may result in better environment measures for the Baltic
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... members to reduce aggression and gain access to scarce ... activities shows a certain pattern across the day. The ... Biology Letters . , Grooming between individuals in a ... To be groomed has hygienic benefits and is stress ... provide access to infants, mating opportunities and high quality ...
(Date:7/11/2014)... of mesenchymal stem cells can stimulate neurogenesis in the ... disease (AD) and improve tissue and function injury under ... on the therapeutic effect of adipose-derived stem cells (ADSCs) ... on oxidative injury and neurogenesis in the brain of ... of Life Sciences, Tsinghua University, China transplanted ADSCs into ...
(Date:7/11/2014)... let nerve cells send out electrical signals, Johns Hopkins ... that may offer a new way to protect crops ... way. , Their findingthat naturally occurring insect toxins ... a closely related onesuggests that insecticides can be designed ... bees. A summary of the research, led by Frank ...
Breaking Biology News(10 mins):Baboons groom early in the day to get benefits later 2Potent spider toxin 'electrocutes' German, not American, cockroaches 2Potent spider toxin 'electrocutes' German, not American, cockroaches 3
... could take greater strides toward crop improvement if there ... the mechanisms that allow plants to adapt to their ... In a perspective for the journal Science , ... Ivan Baxter, a research computational biologist for the U.S. ...
... a kingdom was lost. A similar, seemingly innocuous changethe evolution ... on the carbon cycle, bringing an end to the 60-million ... Coal generated nearly half of the roughly four trillion kilowatt-hours ... to the U.S. Energy Information Administration. This fuel is actually ...
... perfect, red tomatoes from the store just can,t match the ... Institute for Plant Research at Cornell University, USDA and the ... contributes to the level of sugar, carbohydrates and carotenoids in ... Nguyen, a Cornell graduate student in plant breeding working at ...
Cached Biology News:Adoption of advanced techniques could propel crop improvement 2How an ancestral fungus may have influenced coal formation 2How an ancestral fungus may have influenced coal formation 3How an ancestral fungus may have influenced coal formation 4How an ancestral fungus may have influenced coal formation 5How sweet it is: Tomato researchers discover link between ripening, color and taste 2
(Date:7/11/2014)... BEACH, Fla. , July 11, 2014 /PRNewswire-iReach/ -- ... of high-quality peptides that are used solely in scientific ... honor two successful years in business, Maxim Peptide, which ... has just launched a new and updated website that ... research blog section has been updated with fascinating articles ...
(Date:7/11/2014)... , Not for release, publication or distribution (in whole ... to do so would constitute a violation of the relevant ... the "Company") (LSE: SHP, NASDAQ: SHPG ) notes ... a meeting with representatives of AbbVie. This statement ... approval of AbbVie. A further update will be ...
(Date:7/11/2014)... 2014 Research and Markets  has announced ... - Global Industry Analysis, Size, Share, Growth, Trends and ... http://photos.prnewswire.com/prnh/20130307/600769 Transfection ... DNA or RNA) into cells. This technology helps the ... and protein metabolism by affecting the nuclear genes. The ...
(Date:7/11/2014)... (PRWEB) July 11, 2014 BCC Research ... DIGITAL POLYMERASE CHAIN REACTION (PCR) TECHNOLOGY: GLOBAL MARKETS ... (PCR) technology reached nearly $140 billion in 2013. This ... registering a five-year compound annual growth rate (CAGR) of ... number of interesting and exciting possibilities within the broader ...
Breaking Biology Technology:Maxim Peptide Celebrates Second Anniversary Online with an Updated Website and Special Deals Section 2Shire plc - Statement re: Media Speculation 2International Transfection Technology Market - Industry Analysis, Size, Share, Growth, Trends and Forecast to 2019 2Global Market for Digital Polymerase Chain Reaction Technology to Reach $490 Billion by 2018; Equipment Sector Accounts for the Fastest Growing Segment With 33% CAGR 2Global Market for Digital Polymerase Chain Reaction Technology to Reach $490 Billion by 2018; Equipment Sector Accounts for the Fastest Growing Segment With 33% CAGR 3
... PURE Bioscience picks Microsoft technology over competitors for its ... use, scalability and manufacturing capabilities., ... that PURE Bioscience has selected Microsoft Dynamics AX 4.0,to ... the,company,s compliance with the Sarbanes-Oxley Act and with the ...
... Medical,Systems (NYSE: VAR ) announced today that it will report results ... on,Wednesday, April 23, 2008. The news release will be followed by a,teleconference ... Varian Medical Systems quarterly results can be accessed on April 23,2008 via:, ... via phone at 650-424-5834 or via ...
... Biotech Ltd. (Amex:,SVA), a leading provider of vaccines in ... on Monday, March 31, 2008 at 9:00 a.m. ET ... 31, 2007 financial,results and provide an update on recent ... dial 1-877-407-4018 (USA) or,1-201- 689-8471 (international). A replay of ...
Cached Biology Technology:Bioscience Company Chooses Microsoft Dynamics AX to Improve Support for Compliance With Industry Rules 2Bioscience Company Chooses Microsoft Dynamics AX to Improve Support for Compliance With Industry Rules 3Bioscience Company Chooses Microsoft Dynamics AX to Improve Support for Compliance With Industry Rules 4Bioscience Company Chooses Microsoft Dynamics AX to Improve Support for Compliance With Industry Rules 5Varian Medical Systems Schedules Second Quarter FY2008 News Release and Conference Call 2Varian Medical Systems Schedules Second Quarter FY2008 News Release and Conference Call 3Sinovac to Host Conference Call to Report Fourth Quarter and Full Year 2007 Financial Results 2
... assay kit provides complete components including ... convenient detection of DNA fragmentation in ... incorporation of BrdU in the procedure ... digoxigenylated methods. Results can be analyzed ...
... IonQuest will provide great value plus ... detector has very high sensitivities and ... to the standard conductivity detector, the IonQuest ... as electrochemical, refractive index, UV/Visible, WaveQuest UV/Visible ...
... the space and time dimensions of a streak ... microscope to open new horizons in biological imaging. ... excitation, the decay of a fluorescence emission can ... measured. Subtle changes in the local environment ...
... SDS and Non-ionic Detergent Removal ... detergent , Very selective, virtually no cross-reactivity ... centrifuge and discard pellet , Economical ... chromatography , Detergents can often interfere with ...
Biology Products: