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Stem cell mobilization therapy may effectively treat osteoarthritis
Date:6/19/2014

rs. "Further, we demonstrated that the progression of OA was inhibited by the gm-PBSCs."

The researchers noted that the use of G-CSF administration in humans to treat other diseases and conditions has been found to be "safe and effective," despite known side effects such as bone pain, headache, fatigue, and nausea which, they added, are generally "transient, self-limiting and without long-term consequences."

"Although potential long-term adverse effects, such as malignancy after G-CSF administration have been reported, the frequency is low and the relationship between major adverse effects and G-CSF administration is not clear," said Dr. Hung.

The researchers concluded that injection with G-CSF-mobilized peripheral blood stem cells may offer "a convenient protocol for treating OA with consistent beneficial results."

"This study provides further evidence that the use of G-CSF to mobilize stem cells from the bone marrow has potential benefit for a myriad of different disorders, in this case OA." said Dr. Shinn-Zong Lin, professor of Neurosurgery and superintendent at the China Medical University Hospital, Beigang, Taiwan and Coeditor-in-chief of Cell Transplantation. "Further studies are required to determine whether this approach is likely to be effective in humans, but it is promising."


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Contact: Robert Miranda
cogcomm@aol.com
Cell Transplantation Center of Excellence for Aging and Brain Repair
Source:Eurekalert

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